Page last updated: 2024-09-03

swertisin and apigenin

swertisin has been researched along with apigenin in 17 studies

Compound Research Comparison

Studies
(swertisin)
Trials
(swertisin)
Recent Studies (post-2010)
(swertisin)
Studies
(apigenin)
Trials
(apigenin)
Recent Studies (post-2010) (apigenin)
210193,273752,086

Protein Interaction Comparison

ProteinTaxonomyswertisin (IC50)apigenin (IC50)
Chain A, Casein kinase II subunit alphaZea mays1.2
Chain A, Casein kinase II subunit alphaZea mays1.2
Chain A, Casein Kinase Ii Subunit AlphaZea mays1.2
Aldo-keto reductase family 1 member B10Homo sapiens (human)6.6
G2/mitotic-specific cyclin-B2Homo sapiens (human)4
Poly [ADP-ribose] polymerase tankyrase-1Homo sapiens (human)3.1311
Estrogen receptorHomo sapiens (human)1.253
Cytochrome P450 1A1Homo sapiens (human)0.427
MyeloperoxidaseHomo sapiens (human)3.8
Cytochrome P450 1A2Homo sapiens (human)0.795
Cyclin-dependent kinase 1Homo sapiens (human)4
Beta-glucuronidaseRattus norvegicus (Norway rat)2.8
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)6.67
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 23.02
Androgen receptorHomo sapiens (human)5.2
Serine/threonine-protein kinase pim-1Homo sapiens (human)0.94
AromataseHomo sapiens (human)3.275
17-beta-hydroxysteroid dehydrogenase type 1Homo sapiens (human)0.71
Pyruvate kinase PKMHomo sapiens (human)0.99
G2/mitotic-specific cyclin-B1Homo sapiens (human)4
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)2.175
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)2.175
Casein kinase II subunit alpha'Homo sapiens (human)0.85
Amine oxidase [flavin-containing] AHomo sapiens (human)1.398
Amine oxidase [flavin-containing] BHomo sapiens (human)1.12
Dipeptidyl peptidase 4Homo sapiens (human)0.14
Proteasome subunit beta type-5Homo sapiens (human)1.4
Prostaglandin G/H synthase 2Homo sapiens (human)8
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)1.45
Tyrosine-protein kinase SYKHomo sapiens (human)4.2
Xanthine dehydrogenase/oxidaseHomo sapiens (human)1.95
Glycogen synthase kinase-3 alphaHomo sapiens (human)1.4
Glycogen synthase kinase-3 betaHomo sapiens (human)1.4
Mitogen-activated protein kinase 10Homo sapiens (human)2.2
Casein kinase II subunit betaHomo sapiens (human)0.85
Casein kinase II subunit alphaHomo sapiens (human)0.84
Xanthine dehydrogenase/oxidaseBos taurus (cattle)3.57
MO15-related protein kinase Pfmrk Plasmodium falciparum (malaria parasite P. falciparum)7
Cyclin-dependent kinase 6Homo sapiens (human)2.08
Cyclin-dependent-like kinase 5 Homo sapiens (human)2.06
Cyclin homologHerpesvirus saimiri (strain 11)2.175
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)2.06
Mitogen-activated protein kinase 14Homo sapiens (human)2.2
Cytochrome P450 1B1Homo sapiens (human)0.1925
Integrase Human immunodeficiency virus 11.5
Casein kinase II subunit alpha 3Homo sapiens (human)0.8
G2/mitotic-specific cyclin-B3Homo sapiens (human)4
Estrogen receptor betaHomo sapiens (human)0.13
Aurora kinase BHomo sapiens (human)3.96
NACHT, LRR and PYD domains-containing protein 3 Homo sapiens (human)10
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)2.175
Poly [ADP-ribose] polymerase tankyrase-2Homo sapiens (human)2.9256
MAP kinase-interacting serine/threonine-protein kinase 2Homo sapiens (human)0.308
NADPH oxidase 4Homo sapiens (human)1.13
Inositol hexakisphosphate kinase 2Homo sapiens (human)7.1
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.5

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's15 (88.24)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Cazarolli, LH; Folador, P; Gazola, AC; Reginatto, FH; Schenkel, EP; Silva, FR1
Mishra, SH; Patel, MB1
Kano, Y; Wu, CF; Xu, ZL; Yang, JY; Yuan, D; Zhang, L1
Frank, JH; Powder-George, YL; Ramsewak, RS; Reynolds, WF1
Bresolin, TM; Cesca, TG; de Souza, MM; Faqueti, LG; Filho, VC; Meira, NA; Meyre-Silva, C; Quintão, NL; Rocha, LW; Silva, RM1
Arruda, LL; Bannwart, G; Bersani-Amado, CA; Botelho, MF; Fabrão, RM; Ignoato, MC; Pomini, AM; Santin, SM; Schuquel, IT1
Bhonde, RR; Dadheech, N; Dave, A; Gupta, S; Paranjape, N; Shah, GM; Srivastava, A1
Long, P; Lv, Y; Wang, YF; Wang, ZW; Zhang, CH; Zhang, HT; Zhang, N; Zhu, H1
Jang, DS; Jeon, SJ; Kim, E; Kim, H; Ko, SY; Lee, HE; Lee, S; Lee, Y; Park, SJ; Ryu, B; Ryu, JH1
Cheong, JH; Jang, DS; Jeon, SJ; Jung, WY; Kim, E; Kim, HN; Lee, HE; Lee, S; Oh, HK; Park, SJ; Ryu, JH1
Akbar, S; Dar, SA; Ganai, BA; Ghazanfar, K; Hameed, I; Masood, A; Mubashir, K; Nazir, T1
Bhatt, LK; Khanna, A; Mokashi, P; Pandita, N1
Dadheech, N; Gupta, S; Srivastava, A; Vakani, M1
Du, CH; Feng, HX; Jia, JP; Li, Q; Qin, XM; Yan, Y1
Du, H; Qu, C; Wang, Y; Wu, B; Zhao, J1
Chen, J; Cheng, ST; Jiang, H; Ren, F; Ren, JH; Su, Y; Xu, HY; Zhang, CR; Zhou, YJ1
Bhardwaj, G; Gupta, S; Murumkar, P; Pappachan, A; Patel, D; Shah, H; Shah, R; Srivastava, A; Vakani, M1

Other Studies

17 other study(ies) available for swertisin and apigenin

ArticleYear
Potential insulin secretagogue effects of isovitexin and swertisin isolated from Wilbrandia ebracteata roots in non-diabetic rats.
    Fitoterapia, 2010, Volume: 81, Issue:8

    Topics: Animals; Apigenin; Blood Glucose; Cucurbitaceae; Glipizide; Glucose Tolerance Test; Insulin; Insulin Secretion; Male; Molecular Structure; Rats; Rats, Wistar

2010
Hypoglycemic activity of C-glycosyl flavonoid from Enicostemma hyssopifolium.
    Pharmaceutical biology, 2011, Volume: 49, Issue:4

    Topics: Aldehyde Reductase; Animals; Apigenin; Blood Glucose; Cell Line, Tumor; Cells, Cultured; Cytoprotection; Diabetes Mellitus, Experimental; Female; Gentianaceae; Gluconeogenesis; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Insulin; Iridoid Glucosides; Male; Phytotherapy; Plant Components, Aerial; Plant Extracts; Pyrones; Rats; Rats, Wistar

2011
Two new flavonoid glycosides from Semen Ziziphi Spinosae.
    Journal of Asian natural products research, 2012, Volume: 14, Issue:2

    Topics: Apigenin; Drugs, Chinese Herbal; Flavonoids; Glycosides; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular

2012
Variable-temperature ¹H-NMR studies on two C-glycosylflavones.
    Molecules (Basel, Switzerland), 2012, Jul-02, Volume: 17, Issue:7

    Topics: Apigenin; Flavones; Isomerism; Magnetic Resonance Spectroscopy; Models, Molecular; Protons; Temperature

2012
Antinociceptive, anti-inflammatory and wound healing features in animal models treated with a semisolid herbal medicine based on Aleurites moluccana L. Willd. Euforbiaceae standardized leaf extract: semisolid herbal.
    Journal of ethnopharmacology, 2012, Aug-30, Volume: 143, Issue:1

    Topics: Aleurites; Analgesics; Animals; Anti-Inflammatory Agents; Apigenin; Disease Models, Animal; Ear; Edema; Flavones; Flavonoids; Male; Mice; Mice, Inbred Strains; Pain; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Rhamnose; Wound Healing; Wounds and Injuries

2012
Chemical constituents of Machaerium hirtum Vell. (Fabaceae) leaves and branches and its anti-inflammatory activity evaluation.
    Natural product research, 2013, Volume: 27, Issue:17

    Topics: Animals; Anti-Inflammatory Agents; Apigenin; Edema; Fabaceae; Magnetic Resonance Spectroscopy; Mice; Pentacyclic Triterpenes; Plant Extracts; Plant Leaves; Proline; Sitosterols; Stigmasterol; Triterpenes

2013
Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; Apigenin; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cells, Cultured; Down-Regulation; Homeodomain Proteins; Humans; Hypoglycemic Agents; Imidazoles; Islets of Langerhans; Male; Mice; Mice, Inbred BALB C; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Smad Proteins; Stem Cells; Trans-Activators; Transcriptional Activation

2015
[Preliminary comparative study of swertiamarin and swertisin on three kinds of Digeda-species Mongolian medicinal materials].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2015, Volume: 40, Issue:5

    Topics: Apigenin; Chromatography, High Pressure Liquid; Gentianaceae; Gentianella; Iridoid Glucosides; Medicine, Mongolian Traditional; Mongolia; Plant Extracts; Pyrones

2015
Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property.
    Behavioural brain research, 2016, 06-01, Volume: 306

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Apigenin; Avoidance Learning; CHO Cells; Cholinergic Antagonists; CREB-Binding Protein; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Protein Binding; Purinergic P1 Receptor Agonists; Retention, Psychology; Scopolamine

2016
Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice.
    Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:2

    Topics: Acoustic Stimulation; Animals; Apigenin; Cognitive Dysfunction; Dizocilpine Maleate; Flavonoids; Glycogen Synthase Kinase 3; Male; Memory Disorders; Mice; Mice, Inbred ICR; Phosphorylation; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Reflex, Startle; Schizophrenia; Sensory Gating; Signal Transduction

2017
Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles.
    Journal of complementary & integrative medicine, 2017, Apr-29, Volume: 14, Issue:3

    Topics: Animals; Apigenin; Biomarkers; Diabetes Mellitus, Experimental; Female; Gentiana; Hypoglycemic Agents; Insulin-Secreting Cells; Iridoid Glucosides; Male; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Pyrones; Random Allocation; Rats; Rats, Wistar; Treatment Outcome

2017
Swertisin rich fraction from Enicostema littorale ameliorates hyperglycemia and hyperlipidemia in high-fat fed diet and low dose streptozotacin induced type 2 diabetes mellitus in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 96

    Topics: Animals; Antioxidants; Apigenin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Flavonoids; Gentianaceae; Glucose; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Plant Extracts; Rats; Streptozocin

2017
Swertisin ameliorates diabetes by triggering pancreatic progenitors for islet neogenesis in Streptozotocin treated BALB/c mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 100

    Topics: Animals; Apigenin; Cell Differentiation; Diabetes Mellitus, Experimental; Female; Hypoglycemic Agents; Insulin; Islets of Langerhans; Mice, Inbred BALB C; Stem Cells; Streptozocin

2018
[Investigation of the potentially effective components of Semen Ziziphi Spinosae based on “in vitro to in vivo” translation approach].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2017, Volume: 52, Issue:2

    Topics: Animals; Apigenin; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Mass Spectrometry; Rats; Saponins; Ziziphus

2017
Comparison of the Quenching Effects of Two Main Components of Ziziphi Spinosae Semen on Serum Albumin Fluorescence.
    Journal of fluorescence, 2019, Volume: 29, Issue:5

    Topics: Animals; Apigenin; Cattle; Flavonoids; Fluorescence; Humans; Molecular Conformation; Serum Albumin; Spectrometry, Fluorescence; Ziziphus

2019
Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim.
    Journal of ethnopharmacology, 2020, Jul-15, Volume: 257

    Topics: Animals; Antiviral Agents; Apigenin; DNA, Viral; Hep G2 Cells; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Iris Plant; Liver; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Mice, Transgenic; Virus Replication

2020
Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy.
    Archives of biochemistry and biophysics, 2021, 10-15, Volume: 710

    Topics: Animals; Apigenin; Caco-2 Cells; Computer Simulation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; HEK293 Cells; Homeostasis; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Kidney; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Phytotherapy; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2021