transfluthrin: an insecticide
transfluthrin : A carboxylic ester obtained by formal condensation of 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and 2,3,5,6-tetrafluorobenzyl alcohol.
ID Source | ID |
---|---|
PubMed CID | 656612 |
CHEMBL ID | 3184657 |
CHEBI ID | 32253 |
SCHEMBL ID | 26844 |
MeSH ID | M0560535 |
Synonym |
---|
CHEBI:32253 , |
2,3,5,6-tetrafluorobenzyl (1r,3s)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
(2,3,5,6-tetrafluorophenyl)methyl(1r,3s)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
118712-89-3 |
transfluthrin |
transfluthrin (jan) |
D01932 |
(2,3,5,6-tetrafluorophenyl)methyl (1r,3s)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate |
cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (2,3,5,6-tetrafluorophenyl)methyl ester, (1r,3s)- |
transfluthrin [iso] |
unii-qwl3ska6eg |
2,3,5,6-tetrafluorobenzyl (+)-(1r-trans)-2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate |
qwl3ska6eg , |
dtxsid4046812 , |
dtxcid2026812 |
tox21_112675 |
cas-118712-89-3 |
cyclopropanecarboxylicacid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (2,3,5,6-tetrafluorophenyl)methylester, (1r,3s)- |
bayothrin |
AKOS015899270 |
SCHEMBL26844 |
(2,3,5,6-tetrafluorophenyl) methyl (1r)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-carboxylate |
benfluthrin |
transfluthrin [jan] |
cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (2,3,5,6-tetrafluorophenyl)methyl ester, (1r-trans)- |
CHEMBL3184657 |
2,3,5,6-tetrafluorobenzyl (1r,3s)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylate |
transfluthrin, pestanal(r), analytical standard |
2,3,5,6-tetrafluorobenzyl (1r)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate |
DDVNRFNDOPPVQJ-HQJQHLMTSA-N |
transfluthrin 10 microg/ml in cyclohexane |
Q418421 |
CS-0110699 |
DB15117 |
mfcd11045989 |
HY-W075176 |
Transfluthrin is a polyfluorinated pyrethroid whose structural conformation was thought to prevent its metabolism by cytochrome P450 monooxygenases in malaria vectors. It represents a potential alternative for managing P450-mediated resistance occurring in the field.
Excerpt | Reference | Relevance |
---|---|---|
"Transfluthrin is a polyfluorinated pyrethroid whose structural conformation was thought to prevent its metabolism by cytochrome P450 monooxygenases in malaria vectors, thus representing a potential alternative for managing P450-mediated resistance occurring in the field." | ( Deltamethrin and transfluthrin select for distinct transcriptomic responses in the malaria vector Anopheles gambiae. Bonneville, JM; David, JP; Fodjo, BK; Horstmann, S; Laporte, F; McBeath, J; Mouhamadou, CS; Reynaud, S; Sadia, CG; Schmitt, F; Tutagata, J; Zoh, MG, 2023) | 1.97 |
"Transfluthrin is a relatively non-toxic rapid-acting synthetic pyrethroid insecticide. " | ( Gas chromatography/negative chemical ionization mass spectrometry of transfluthrin in rat plasma and brain. Bartlett, MG; Bruckner, JV; Gullick, DR; Hooshfar, S; Linzey, MR; Mortuza, TB; Rogers, CA; White, CA, 2017) | 2.13 |
Transfluthrin-treated EPTI could be useful in areas with pyrethroid-resistant mosquitoes. It remains unclear whether stronger resistance to pyrethroids will undermine the efficacy of transfluthin. Transfluthrine-treated eave ribbons can protect migratory rice farmers, living in semi-open makeshift houses in remote farms.
Excerpt | Reference | Relevance |
---|---|---|
" According to any modifications of the process of synthesis and purification, new potentially highly toxic and yet chemically reactive impurities in low concentrations (<0." | ( Transfluthrin: comparative efficacy and toxicity of reference and generic versions. Ozaki, K; Pauluhn, J, 2015) | 1.86 |
" Here, we describe EPs' toxic effect and mechanism in the primary fibroblast derived from the embryo of the striped field mouse, Apodemus agrarius." | ( Toxicity Assessment of Transfluthrin, Benzyl Butyl Phthalate, and 17β-Estradiol on the Primary Fibroblast of the Striped Field Mouse, Apodemus agrarius. Chang, SN; Kim, U; Lee, BH; Lee, JM; Park, JH; Ryu, B; Song, J, 2021) | 0.93 |
Excerpt | Reference | Relevance |
---|---|---|
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
" Designed for post-application longevity, insecticidal paints offer extended residual effects on targeted insect pest populations; a measured understanding of active ingredient bioavailability over time is valuable to fully assess treatment efficacy and potential environmental risks." | ( Measured efficacy, bioaccumulation, and leaching of a transfluthrin-based insecticidal paint: a case study with a nuisance, nonbiting aquatic insect. Cavallaro, MC; Hladik, ML; Sanders, CJ, 2022) | 0.97 |
Role | Description |
---|---|
pyrethroid ester insecticide | null |
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Class | Description |
---|---|
carboxylic ester | An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl. |
cyclopropanes | Cyclopropane and its derivatives formed by substitution. |
organochlorine compound | An organochlorine compound is a compound containing at least one carbon-chlorine bond. |
organofluorine compound | An organofluorine compound is a compound containing at least one carbon-fluorine bond. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (1.47) | 29.6817 |
2010's | 37 (54.41) | 24.3611 |
2020's | 30 (44.12) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (60.62) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 2 (2.78%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 2 (2.78%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 68 (94.44%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |