Compounds > nvc-422
Page last updated: 2024-11-12

nvc-422

Description

NVC-422: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11708365
CHEMBL ID1207907
SCHEMBL ID994601
MeSH IDM0560808

Synonyms (22)

Synonym
2-(dichloroamino)-2-methyl-propane-1-sulfonic acid
CHEMBL1207907
dcdmt
aganase
nvc-422
846056-87-9
1-propanesulfonic acid, 2-(dichloroamino)-2-methyl-
cd0722
auriclosene
bkr7y95229 ,
unii-bkr7y95229
n,n-dichloro-2,2-dimethyltaurine
nvc 422
auriclosene [inn]
nvc422
DTXSID80233617
SCHEMBL994601
2-(dichloroamino)-2-methylpropane-1-sulfonic acid
DB12197
aganas
Q27274738
AKOS040750635

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The aim of this study was to show that these compounds are safe in an EpiOcular model and effective in corneas infected ex vivo."( N-chlorotaurine and its analogues N,N-dichloro-2,2-dimethyltaurine and N-monochloro-2,2-dimethyltaurine are safe and effective bactericidal agents in ex vivo corneal infection models.
Anderson, M; Bechrakis, NE; Debabov, D; Eitzinger, C; Hager, T; Jekle, A; Lutz, M; Nagl, M; Schmid, E; Teuchner, B; Zuck, M, 2012)		0.38
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.05 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (8.33%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
taurine
[no description available]		5.25111amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0710aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		2.4820aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
n-chlorotaurine
N-chlorotaurine: inhibits both inducible nitric oxide synthase and IkappaB kinase		7.9940
mupirocin
Mupirocin: A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.. mupirocin : An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.		2.0710alpha,beta-unsaturated carboxylic ester;
epoxide;
monocarboxylic acid;
oxanes;
secondary alcohol;
triol		antibacterial drug;
bacterial metabolite;
protein synthesis inhibitor
fusidic acid
Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.. fusidic acid : A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.		2.071011alpha-hydroxy steroid;
3alpha-hydroxy steroid;
alpha,beta-unsaturated monocarboxylic acid;
steroid acid;
steroid antibiotic;
sterol ester		EC 2.7.1.33 (pantothenate kinase) inhibitor;
Escherichia coli metabolite;
protein synthesis inhibitor
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.0610cysteiniumfundamental metabolite
retapamulin
retapamulin: a synthetic pleuromutilin		2.0710carbotricyclic compound;
carboxylic ester;
cyclic ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Dermatophytoses
[description not available]		02.0810
Tinea
Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.		02.0810
Infections, Proteus
[description not available]		02.1310
E coli Infections
[description not available]		02.0610
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.		02.0610
Impetigo Contagiosa
[description not available]		03.4511
Impetigo
A common superficial bacterial infection caused by STAPHYLOCOCCUS AUREUS or group A beta-hemolytic streptococci. Characteristics include pustular lesions that rupture and discharge a thin, amber-colored fluid that dries and forms a crust. This condition is commonly located on the face, especially about the mouth and nose.		110.4511
Viral Conjunctivitis
[description not available]		07.4820
Human Adenovirus Infections
[description not available]		02.0610
Adenovirus Infections, Human
Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.		02.0610
Conjunctivitis, Viral
Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.		14.4820
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0710
Infections, Pseudomonas
[description not available]		02.0710
Infections, Staphylococcal
[description not available]		02.4820
Bacterial Eye Infections
[description not available]		02.0710
Keratitis
Inflammation of the cornea.		02.0710
Pseudomonas Infections
Infections with bacteria of the genus PSEUDOMONAS.		02.0710
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.4820
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