Compounds > n,n-dimethyldopamine
Page last updated: 2024-12-08

n,n-dimethyldopamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N,N-dimethyldopamine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID152427
CHEMBL ID347228
SCHEMBL ID67764
MeSH IDM0124095

Synonyms (16)

Synonym
n,n-dmda
CHEMBL347228
i5r8511l9n ,
1,2-benzenediol, 4-(2-(dimethylamino)ethyl)-
unii-i5r8511l9n
21581-37-3
n,n-dimethyldopamine
1,2-benzenediol,4-[2-(dimethylamino)ethyl]-
SCHEMBL67764
dimethyldopamine, n,n-
XJTVXBWTYZCUJX-UHFFFAOYSA-N
4-[2-(dimethylamino)ethyl]-1,2-benzenediol #
DTXSID00175944
Q6951324
4-[2-(dimethylamino)ethyl]benzene-1,2-diol
EN300-2914516
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID1131626Induction of pecking in im dosed pigeon1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131682Toxicity in dog up to 2 mg/kg, sc1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131620Inhibition of cardioaccelerator nerve stimulation in dog in presence of phentolamine1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131617Inhibition of 10 Hz electric current-induced cardioaccelerator nerve stimulation in iv dosed cat by cardiotachometer analysis1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131670Induction of hyperactivity in Sprague-Dawley rat at 3.13 to 50 ug administered into nucleus accumbens1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131638Induction of stereotyped behaviour in Sprague-Dawley rat at 2.5 to 20 mg/kg, sc1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131669Induction of stereotyped behaviour in intrastriatally dosed Sprague-Dawley rat at 3.13 to 50 ug administered into caudate putamen1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131623Induction of emesis in sc dosed dog1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131689Agonist activity at dopamine receptor in cat right atrium assessed as inhibition of cardiaccelerator nerve stimulation rate by cardiotachometer analysis1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131628Effect on heart rate in iv dosed cat1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131688Induction of hyperactivity in Sprague-Dawley rat at 2.5 to 20 mg/kg, sc1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131619Inhibition of 2 Hz electric current-induced cardioaccelerator nerve stimulation in iv dosed cat by cardiotachometer analysis in presence of 2 mg/kg, iv phentolamine1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131624Antagonism of apomorphine-induced emesis in sc dosed dog treated 15 mins prior to apomorphine challenge1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131618Inhibition of 2 Hz electric current-induced cardioaccelerator nerve stimulation in iv dosed cat by cardiotachometer analysis in presence of 0.2 mg/kg, iv haloperidol1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131671Induction of stereotyped behaviour in intrastriatally dosed Sprague-Dawley rat at 3.13 to 50 ug administered into nucleus accumbens1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131668Induction of hyperactivity in Sprague-Dawley rat at 3.13 to 50 ug administered into caudate putamen1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131615Inhibition of 2 Hz electric current-induced cardioaccelerator nerve stimulation in iv dosed cat by cardiotachometer analysis1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID1131646Induction of circling behaviour in Sprague-Dawley rat at 2.5 to 20 mg/kg, sc1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
AID132337Compound concentration that causes inhibition of [3H]-acetyl choline release by 50% was determined using reserpine-alpha MPT treated mice striatal slices1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Dopaminergic agonists: comparative actions of amine and sulfonium analogues of dopamine.
AID1131627Antagonism of apomorphine-induced pecking in im dosed pigeon treated 15 mins prior to apomorphine challenge1978Journal of medicinal chemistry, Mar, Volume: 21, Issue:3
Preparation and biological actions of some symmetrically N,N-disubstituted dopamines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ammonium hydroxide
azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.		1.9710azane;
gas molecular entity;
mononuclear parent hydride		EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant
n,n-di-n-propyldopamine
N,N-di-n-propyldopamine: RN given refers to parent cpd		2.3620catecholamine
racemetirosine
alpha-Methyltyrosine: An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)		1.9710
adtn
ADTN: RN given refers to parent cpd without isomeric designation; structure		1.9610
haloperidol
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.		1.9710aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
mazindol
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.		1.9710organic molecular entity
metoclopramide
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.. metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.		1.9610benzamides;
monochlorobenzenes;
substituted aniline;
tertiary amino compound		antiemetic;
dopaminergic antagonist;
environmental contaminant;
gastrointestinal drug;
xenobiotic
deoxyepinephrine
Deoxyepinephrine: Sympathomimetic, vasoconstrictor agent.		1.9610catecholamine
procaine
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).. procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.		1.9710benzoate ester;
substituted aniline;
tertiary amino compound		central nervous system depressant;
drug allergen;
local anaesthetic;
peripheral nervous system drug
reserpine
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.		1.9710alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
apomorphine
Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.		1.9710aporphine alkaloidalpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug
apomorphine hydrochloride, anhydrous
[no description available]		1.9510
alpha-methyldopamine
[no description available]		1.9610amphetamines
cocaine
Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.		1.9710benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		1.9710chalcogen;
nonmetal atom		macronutrient
ConditionIndicatedRelationship StrengthStudiesTrials
Intraocular Pressure
The pressure of the fluids in the eye.		01.9610