jnj-10191584 and Hypersensitivity

jnj-10191584 has been researched along with Hypersensitivity* in 1 studies

Other Studies

1 other study(ies) available for jnj-10191584 and Hypersensitivity

Article	Year
Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics. Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1 The histamine H(4) receptor is a G protein-coupled receptor that has attracted much interest for its role in inflammatory and immunomodulatory functions. In our search for new H(4)R ligands, a low affinity isoquinoline fragment was optimized to 7-(furan-2-yl)-4-(piperazin-1-yl)quinazolin-2-amine (VUF11489), as a new H(4)R antagonist. Analysis of its binding kinetics at the human H(4)R showed this compound to have a very different dissociative half-life in comparison with reference antagonist JNJ7777120. Topics: Animals; Biological Availability; Chemistry, Pharmaceutical; Drug Design; Histamine Antagonists; Humans; Hypersensitivity; Inhibitory Concentration 50; Kinetics; Ligands; Mice; Models, Chemical; Models, Molecular; Molecular Conformation; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship; Time Factors	2012

Article

Year

Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.

Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

The histamine H(4) receptor is a G protein-coupled receptor that has attracted much interest for its role in inflammatory and immunomodulatory functions. In our search for new H(4)R ligands, a low affinity isoquinoline fragment was optimized to 7-(furan-2-yl)-4-(piperazin-1-yl)quinazolin-2-amine (VUF11489), as a new H(4)R antagonist. Analysis of its binding kinetics at the human H(4)R showed this compound to have a very different dissociative half-life in comparison with reference antagonist JNJ7777120.

Topics: Animals; Biological Availability; Chemistry, Pharmaceutical; Drug Design; Histamine Antagonists; Humans; Hypersensitivity; Inhibitory Concentration 50; Kinetics; Ligands; Mice; Models, Chemical; Models, Molecular; Molecular Conformation; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship; Time Factors

2012