Compounds > glycidyl 1-naphthyl ether
Page last updated: 2024-11-06

glycidyl 1-naphthyl ether

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

glycidyl 1-naphthyl ether: induces hypoxanthine phosphoribosyl transferase mutants [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID91521
CHEMBL ID1929345
SCHEMBL ID93314
MeSH IDM0220618

Synonyms (71)

Synonym
AC-6380
3-(1-naphthoxy)-1,2-epoxypropane
nsc 632
einecs 219-555-7
1-naphthyl glycidyl ether
oxirane, ((1-naphthalenyloxy)methyl)-
glycidyl 1-naphthyl ether
brn 0160552
((naphthyloxy)methyl)oxirane
naphthalene, 1-(2,3-epoxypropoxy)-
ether, 2,3-epoxypropyl 1-naphthyl
ccris 2069
1,2-epoxy-3-(1-naphthyloxy)propane
nsc632
2461-42-9
nsc-632
AKOS000200355
1,2-epoxy-3-(1-naphthoxy)-propane
r-(-)-|a-naphthyl glycidyl ether
2-(naphthalen-1-yloxymethyl)oxirane
(2s)-2-(1-naphthyloxymethyl)oxirane;2-[(1-naphthyloxy)methyl]oxirane
A817398
2-[(naphthalen-1-yloxy)methyl]oxirane
EN300-09936
2-[(1-naphthyloxy)methyl]oxirane
2-((naphthalen-1-yloxy)methyl)oxirane
07fn14f351 ,
unii-07fn14f351
2-(1-naphthyloxymethyl)oxirane
FT-0672646
FT-0672647
CHEMBL1929345
1-naphthol glycidyl ether
FT-0634300
glycidyl .alpha.-naphthyl ether
(+/-)-1-(1-naphthyloxy)-2,3-epoxypropane
1-(2,3-epoxypropoxy)naphthalene
SCHEMBL93314
1-naphthyl epoxypropyl ether
2-((naphthalene-1-yloxy)methyl)oxirane
1,2-epoxy-3-(1-naphthalenyloxy)propane
1,2-epoxy-3-(1-naphthyloxy)-propane
alpha-naphthyl glycidyl ether
2,3-epoxypropyl 1-naphthyl ether
(1-naphthyl)glycidyl ether
2-(1-naphthyloxy)methyloxirane
1,2-epoxy-3-(1-naphthoxy)propane
2,3-epoxy-1-(1-naphthyloxy)-propane
2,3-epoxypropyl naphthyl ether
1-(1-naphthyloxy)-2,3-epoxypropane
1-naphthyloxy-2,3-epoxypropane
2-((1-naphthyloxy)methyl)oxirane
AKOS016037123
W-107293
naphthyl glycidyl ether
oxirane, [(1-naphthalenyloxy)methyl]-
2-[(1-naphthyloxy)methyl]oxirane #
oxirane, [(naphthalenyloxy)methyl]-
F20585
naphthyl glycidyl ethe
Z90123337
3-(1-naphthalenyloxy)-1,2-cyclopropane(naftopidil intermediate)
mfcd00055643
propranolol epoxide impurity
?-naphthyl glycidyl ether; 2-[(1-naphthalenyloxy)methyl]oxirane; 1-(2,3-epoxypropoxy)naphthalene
3-(1-naphthalenyloxy)-1,2-cyclopropane
Q27236303
?-naphthyl glycidyl ether, 90%
alpha -naphthyl glycidyl ether
alpha-naphthyl glycidyl ether, 90per cent
DTXSID501030986
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID636075Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs by lactate dehydrogenase assay2012Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents.
AID636078Cytotoxicity against CHO cells after 48 hrs by MTT assay2012Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents.
AID636076Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by lactate dehydrogenase assay2012Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (20.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phenol
[no description available]		2.0710phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
alprenolol
Alprenolol: One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.. alprenolol : A secondary alcohol that is propan-2-ol substituted by a 2-allylphenoxy group at position 1 and an isopropylamino group at position 3. It is a beta-adrenergic antagonist used as a antihypertensive, anti-arrhythmia and a sympatholytic agent.		2.110secondary alcohol;
secondary amino compound		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.0710aromatic ether;
nitrile;
polyether;
tertiary amino compound
mefloquine hydrochloride
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.		2.0710organofluorine compound;
piperidines;
quinolines;
secondary alcohol
propranolol
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.. propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.		2.4920naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
1-naphthol
1-naphthol: RN given refers to parent cpd. 1-naphthol : A naphthol carrying a hydroxy group at position 1.. hydroxynaphthalene : Any member of the class of naphthalenes that is naphthalene carrying one or more hydroxy groups.		2.0710naphtholgenotoxin;
human xenobiotic metabolite
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		3.150naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
emetine
Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.. emetine : A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.		2.0710isoquinoline alkaloid;
pyridoisoquinoline		antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor
1,2-epoxy-3-(p-nitrophenoxy)propane
1,2-epoxy-3-(p-nitrophenoxy)propane: a protease inhibitor. 1,2-epoxy-3-(4-nitrophenoxy)propane : An epoxide that is oxirane substituted by a (4-nitrophenoxy)methyl group.		1.9810aromatic ether;
C-nitro compound;
epoxide
phenylglycidyl ether
phenylglycidyl ether: structure		2.0710aromatic ether
totarol
totarol: structure given in first source; isolated from the bark of Podocarpus nagi		2.0710diterpenoidmetabolite
thioguanine anhydrous
Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.. tioguanine : A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.		1.98102-aminopurinesanticoronaviral agent;
antimetabolite;
antineoplastic agent
nitrophenols
Nitrophenols: PHENOLS carrying nitro group substituents.		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Dermatitis Medicamentosa
[description not available]		01.9810