genkwadaphnin: from Daphne genkwa; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Daphne | genus | A plant genus of the family THYMELAEACEAE. They are evergreen shrubs much cultivated in garden borders and rock gardens in mild climates. Members contain mezerein, flavonoids, and COUMARINS such as daphnetin and daphnin.[MeSH] | Thymelaeaceae | A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 124210 |
| MeSH ID | M0110950 |
| Synonym |
|---|
| brn 1675425 |
| 12-beta-(benzoyloxy)daphnetoxin |
| daphnetoxin, 12-(benzoyloxy)-, (12beta)- |
| daphnetoxin, 12-(benzoyloxy)-, (12-beta)- |
| genkwadaphnin |
| 55073-32-0 |
| DTXSID10970422 |
| 5,5a-dihydroxy-4a-(hydroxymethyl)-7,9-dimethyl-6-oxo-2-phenyl-10a-(prop-1-en-2-yl)-3a,3c,4a,5,5a,6,8a,9,10,10a-decahydro-2h,3bh-2,8b-epoxyoxireno[6,7]azuleno[5,4-e][1,3]benzodioxol-10-yl benzoate |
| [(1r,2r,6s,7s,8r,10s,11s,12r,14r,16s,17r,18r)-6,7-dihydroxy-8-(hydroxymethyl)-4,18-dimethyl-5-oxo-14-phenyl-16-prop-1-en-2-yl-9,13,15,19-tetraoxahexacyclo[12.4.1.01,11.02,6.08,10.012,16]nonadec-3-en-17-yl] benzoate |
Genkwadaphnin is a daphnane diterpene ester molecule isolated from the flower buds of Daphne genkwa.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Genkwadaphnin (GD) is a daphnane diterpene isolated from the flower buds of Daphne genkwa Siebold et Zuccarini (Thymelaeaceae)." | ( Genkwadaphnin inhibits growth and invasion in hepatocellular carcinoma by blocking DHCR24-mediated cholesterol biosynthesis and lipid rafts formation. Cui, W; Guo, L; Li, F; Qiu, X; Ren, Y; Song, S; Wu, J, 2020) | 2.72 |
| "Genkwadaphnin is a daphnane diterpene ester molecule isolated from the flower buds of Daphne genkwa. " | ( Genkwadaphnin induces reactive oxygen species (ROS)-mediated apoptosis of squamous cell carcinoma (SCC) cells. Choi, DK; Kim, CD; Kim, JW; Kim, SJ; Lee, JH; Li, XM; Li, ZJ; Piao, YJ; Sohn, KC, 2014) | 3.29 |
Genkwadaphnin treatment increased phosphorylation of c-Jun N-terminal kinase. ATDC5 cells also stained more intensely with Alcian blue than control cells. This suggests greater synthesis of matrix proteoglycans in the former.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Genkwadaphnin treatment increased phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK)." | ( Genkwadaphnin induces reactive oxygen species (ROS)-mediated apoptosis of squamous cell carcinoma (SCC) cells. Choi, DK; Kim, CD; Kim, JW; Kim, SJ; Lee, JH; Li, XM; Li, ZJ; Piao, YJ; Sohn, KC, 2014) | 2.57 |
| "Genkwadaphnin treated ATDC5 cells also stained more intensely with Alcian blue than control cells, suggesting greater synthesis of matrix proteoglycans in the former." | ( Stimulation of chondrogenesis in ATDC5 chondroprogenitor cells and hypertrophy in mouse by Genkwadaphnin. Choi, HJ; Lee, HK; Nepal, M; Oh, SR; Park, YR; Soh, Y, 2011) | 1.31 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||