Page last updated: 2024-11-12

eudistomin u

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

eudistomin U: an alkaloid from the Carribean ascidian Lissoclinum fragile; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10334023
CHEMBL ID3309924
SCHEMBL ID3400592
MeSH IDM0233227

Synonyms (5)

Synonym
eudistomin u
inchi=1/c19h13n3/c1-3-7-16-13(6-1)15(11-21-16)18-19-14(9-10-20-18)12-5-2-4-8-17(12)22-19/h1-11,21-22
SCHEMBL3400592
CHEMBL3309924
1-(1h-indol-3-yl)-9h-pyrido[3,4-b]indole

Research Excerpts

Overview

Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA.

ExcerptReferenceRelevance
"Eudistomin U is a member of a subclass of naturally occurring indole alkaloids known as β-carbolines. "( Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
Giulietti, JM; Mulcahy, SP; Roggero, CM, 2014
)
2.16
"Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. "( DNA-binding studies of the natural β-carboline eudistomin U.
Cai, A; Cho, B; Giulietti, JM; Mulcahy, SP; Tate, PM, 2016
)
2.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (33)

Assay IDTitleYearJournalArticle
AID1632784Binding affinity to calf thymus duplex DNA assessed as induction of hyperchromic shift at 257 nanometer at 50 uM in pH 5.4 phosphate buffer by UV-vis spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1179876Antibacterial activity against Mycobacterium smegmatis measured every 2.5 hrs by spectrophotometry2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1632793Binding affinity to calf thymus duplex DNA assessed as induction of ellipticity at 25 to 200 uM in pH 5.4 phosphate buffer by circular dichroism method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1846883Antimalarial activity against chloroquine-resistant Plasmodium falciparum2021European journal of medicinal chemistry, Oct-05, Volume: 221Structure activity relationship in β-carboline derived anti-malarial agents.
AID1632779Binding affinity to calf thymus duplex DNA assessed as red shift in soret peak at 50 uM in pH 7 phosphate buffer by UV-vis spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632792Binding affinity to calf thymus duplex DNA assessed as induction of hyperchromicity at 280 nanometer at 25 to 200 uM in pH 7 phosphate buffer by circular dichroism method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632798Binding affinity to calf thymus duplex DNA assessed as induction of ellipticity at 25 to 200 uM in pH 8.9 phosphate buffer by circular dichroism method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632803Binding affinity to calf thymus duplex DNA assessed as melting temperature at 5 mM by differential scanning calorimetry (Rvb = 51 degC)2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632795Binding affinity to calf thymus AT-rich duplex DNA assessed as induction of ellipticity at 25 to 200 uM in pH 7 phosphate buffer by circular dichroism method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1894524Cytotoxicity against mouse C19 cells assessed as cell growth inhibition by MTT assay2021European journal of medicinal chemistry, Apr-15, Volume: 216β-Carbolines as potential anticancer agents.
AID1632794Binding affinity to calf thymus GC-rich duplex DNA assessed as induction of ellipticity at 25 to 200 uM in pH 7 phosphate buffer by circular dichroism method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1179875Antibacterial activity against Staphylococcus aureus measured after overnight incubation by spectrophotometry2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1632789Binding affinity to calf thymus GC-rich duplex DNA assessed as induction of hyperchromicity at 25 to 200 uM in pH 7 phosphate buffer by circular dichroism method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632805Binding affinity to calf thymus duplex DNA assessed as increase in melting temperature by differential scanning calorimetry2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632801Binding affinity to calf thymus duplex DNA assessed as induction of ellipticity at 349 nanometer at 25 to 200 uM in pH 7 phosphate buffer by circular dichroism method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1179874Antibacterial activity against Streptococcus pyogenes measured after overnight incubation by spectrophotometry2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1179872Cytotoxicity against human Caov3 cells after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1179878Antibacterial activity against Candida albicans measured every 2.5 hrs by spectrophotometry2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1179881Growth inhibition of mouse P388 cells at 10 uM2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1179877Antibacterial activity against Pseudomonas aeruginosa measured after overnight incubation by spectrophotometry2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1632790Binding affinity to calf thymus AT-rich duplex DNA assessed as induction of hyperchromicity at 25 to 200 uM in pH 7 phosphate buffer by circular dichroism method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1179880Antibacterial activity against Escherichia coli measured after overnight incubation by spectrophotometry2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1632786Binding affinity to calf thymus duplex DNA assessed as induction of red shift in soret peak at 50 uM in pH 5.4 phosphate buffer by UV-vis spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632783Binding affinity to calf thymus duplex DNA assessed as induction of hyperchromic shift at 257 nanometer at 50 uM in pH 8.9 phosphate buffer by UV-vis spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632791Binding affinity to calf thymus duplex DNA assessed as induction of red shift at 280 nanometer at 25 to 200 uM in pH 7 phosphate buffer by circular dichroism method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632787Binding affinity to calf thymus duplex DNA assessed as change in melting temperature at 50 uM in pH 7 phosphate buffer by UV-vis spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632797Binding affinity to calf thymus duplex DNA assessed as induction of ellipticity at 25 to 200 uM in pH 7 phosphate buffer in presence of 0.1 M NaCl by circular dichroism method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1179879Antibacterial activity against Saccharomyces cerevisiae measured every 2.5 hrs by spectrophotometry2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1632781Binding affinity to calf thymus duplex DNA assessed as induction of hyperchromic shift at 257 nanometer at 50 uM in pH 7 phosphate buffer by UV-vis spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1632802Binding affinity to calf thymus duplex DNA assessed as melting temperature at 1 mM by differential scanning calorimetry (Rvb = 51 degC)2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
AID1179871Cytotoxicity against human C19 cells after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1179873Cytotoxicity against human WM266.4 cells after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Efficient synthesis of eudistomin U and evaluation of its cytotoxicity.
AID1632785Binding affinity to calf thymus duplex DNA assessed as induction of red shift in soret peak at 50 uM in pH 8.9 phosphate buffer by UV-vis spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
DNA-binding studies of the natural β-carboline eudistomin U.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's1 (10.00)29.6817
2010's6 (60.00)24.3611
2020's2 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]