eudistomin-u and norharman

eudistomin-u has been researched along with norharman* in 2 studies

Other Studies

2 other study(ies) available for eudistomin-u and norharman

Article	Year
DNA-binding studies of the natural β-carboline eudistomin U. Bioorganic & medicinal chemistry letters, 2016, 10-01, Volume: 26, Issue:19 Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple β-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV-Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class. Topics: Calorimetry, Differential Scanning; Carbolines; Circular Dichroism; DNA; Spectrophotometry, Ultraviolet; Structure-Activity Relationship	2016
PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I. Organic & biomolecular chemistry, 2015, Aug-28, Volume: 13, Issue:32 Iodobenzene diacetate was employed as a mild and efficient reagent for one-pot oxidative decarboxylation of tetrahydro-β-carboline acids and dehydrogenation of tetrahydro-β-carbolines to access the corresponding aromatic β-carbolines. To the best of our knowledge this is the first synthesis of β-carbolines via a one-pot oxidative decarboxylation at ambient temperature. The utility of this protocol has been demonstrated in the synthesis of β-carboline alkaloids norharmane (2o), harmane (2p), eudistomin U (9) and eudistomin I (12). Topics: Acetates; Carbolines; Decarboxylation; Harmine; Iodobenzenes; Molecular Structure; Oxidation-Reduction	2015

Article

Year

DNA-binding studies of the natural β-carboline eudistomin U.

Bioorganic & medicinal chemistry letters, 2016, 10-01, Volume: 26, Issue:19

Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple β-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV-Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class.

Topics: Calorimetry, Differential Scanning; Carbolines; Circular Dichroism; DNA; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

2016

PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I.

Organic & biomolecular chemistry, 2015, Aug-28, Volume: 13, Issue:32

Iodobenzene diacetate was employed as a mild and efficient reagent for one-pot oxidative decarboxylation of tetrahydro-β-carboline acids and dehydrogenation of tetrahydro-β-carbolines to access the corresponding aromatic β-carbolines. To the best of our knowledge this is the first synthesis of β-carbolines via a one-pot oxidative decarboxylation at ambient temperature. The utility of this protocol has been demonstrated in the synthesis of β-carboline alkaloids norharmane (2o), harmane (2p), eudistomin U (9) and eudistomin I (12).

Topics: Acetates; Carbolines; Decarboxylation; Harmine; Iodobenzenes; Molecular Structure; Oxidation-Reduction

2015