Page last updated: 2024-11-12

drosocin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

drosocin: amino acid sequence given in first source for drosocin and its precursor; GenBank Z21942 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16131048
CHEMBL ID217215
MeSH IDM0218898

Synonyms (7)

Synonym
149924-99-2
l-valine, glycyl-l-lysyl-l-prolyl-l-arginyl-l-prolyl-l-tyrosyl-l-seryl-l-prolyl-l-arginyl-l-prolyl-l-threonyl-l-seryl-l-histidyl-l-prolyl-l-arginyl-l-prolyl-l-isoleucyl-l-arginyl-
glycyl-l-lysyl-l-prolyl-l-arginyl-l-prolyl-l-tyrosyl-l-seryl-l-prolyl-l-arginyl-l-prolyl-l-threonyl-l-seryl-l-histidyl-l-prolyl-l-arginyl-l-prolyl-l-isoleucyl-l-arginyl-l-valine
gkprpysprptshprpirv
drosocin
CHEMBL217215
DTXSID50164429

Research Excerpts

Overview

Drosocin is a cationic 19 amino acid peptide secreted by Drosophila in response to septic injury.

ExcerptReferenceRelevance
"Drosocin is a 19-mer, cationic antimicrobial peptide from Drosophila melanogaster. "( Evaluation of the antibacterial spectrum of drosocin analogues.
Bikker, FJ; de Visser, PC; de Vries-van de Ruit, AM; Kaman-van Zanten, WE; Mars-Groenendijk, RH; Noort, D; van Hooft, PA; Voskamp-Visser, I, 2006
)
2.04
"Drosocin is a cationic 19 amino acid peptide secreted by Drosophila in response to septic injury. "( Conformational studies by NMR of the antimicrobial peptide, drosocin, and its non-glycosylated derivative: effects of glycosylation on solution conformation.
Craik, DJ; Hoffmann, R; McManus, AM; Otvos, L, 1999
)
1.99
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID511695Cytotoxicity against human CEM-SS cells infected with HIV1 3B after 6 days by XTT assay2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.
AID94139Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Klebsiella pneumoniae 792002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID198004Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Staphylococcus enteritidis D52002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID94138Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Klebsiella pneumoniae 222002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID1197604Antimicrobial activity against Escherichia coli ATCC 25922 by broth microdilution assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Understanding the importance of glycosylated threonine and stereospecific action of Drosocin, a Proline rich antimicrobial peptide.
AID9221Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Acinetobacter baumannii 118A2002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID64242Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Escherichia coli ML-352002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID1197607Antimicrobial activity against Salmonella typhimurium ATCC 14028 by broth microdilution assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Understanding the importance of glycosylated threonine and stereospecific action of Drosocin, a Proline rich antimicrobial peptide.
AID1197605Antimicrobial activity against Escherichia coli ATCC 11775 by broth microdilution assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Understanding the importance of glycosylated threonine and stereospecific action of Drosocin, a Proline rich antimicrobial peptide.
AID482395Cytotoxicity against human SH-SY5Y cells at 600 ug/ml after 24 hrs by MTT assay2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID198005Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 h of incubation at 37 C in Mueller-Hinton broth against Staphylococcus enteritidis PD12002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID64223Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Escherichia coli D222002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID511694Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay2010Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.
AID244840Minimum inhibitory concentration against Escherichia coli ATCC 11775 strain2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
Biological evaluation of Tyr6 and Ser7 modified drosocin analogues.
AID64219Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Escherichia coli D212002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID64243Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Escherichia coli O18:K1:H72002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID1197606Antimicrobial activity against Escherichia coli ATCC 35218 by broth microdilution assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Understanding the importance of glycosylated threonine and stereospecific action of Drosocin, a Proline rich antimicrobial peptide.
AID150919Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Pseudomonas aeruginosa ATCC 278532002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID249731Percent of intact peptide after 8 hr of digestion in 25% human serum2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
Biological evaluation of Tyr6 and Ser7 modified drosocin analogues.
AID482394Cytotoxicity against human HeLa cells at 600 ug/ml after 24 hrs by MTT assay2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID1197608Antimicrobial activity against Salmonella typhi Vi+ by broth microdilution assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Understanding the importance of glycosylated threonine and stereospecific action of Drosocin, a Proline rich antimicrobial peptide.
AID197876Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Staphylococcus aureus G2002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID198329Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Salmonella Typhimurium ATCC 140282002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID64216Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Escherichia coli ATCC 259222002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
AID198008Minimum inhibitory concentration (lowest peptide concentration) required to prevent visible bacterial growth after 18 hr of incubation at 37 C in Mueller-Hinton broth against Staphylococcus epidermidis 42002Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
Antimicrobial peptides: synthesis and antibacterial activity of linear and cyclic drosocin and apidaecin 1b analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (37)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's9 (24.32)18.2507
2000's11 (29.73)29.6817
2010's14 (37.84)24.3611
2020's3 (8.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.31 (24.57)
Research Supply Index3.64 (2.92)
Research Growth Index4.61 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (5.41%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other35 (94.59%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]