Compounds > oncocin
Page last updated: 2024-11-13

oncocin

Description

oncocin: a synthetic peptide [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID46889826
CHEMBL ID1083466
MeSH IDM0549246

Synonyms (2)

Synonym
oncocin
CHEMBL1083466

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The pharmacokinetic profiles explain the high in vivo efficacies in models of systemic infection and indicate the potential use of these agents for the treatment of urinary tract infections."( Pharmacokinetics and in vivo efficacy of optimized oncocin derivatives.
Hoffmann, R; Knappe, D; Ostorházi, E; Schmidt, R; Wende, E, 2016)		0.69
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (50)

Assay IDTitleYearJournalArticle
AID482409Antimicrobial activity against Pseudomonas aeruginosa Walter after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482397Antimicrobial activity against Proteus vulgaris ICB 9081 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482382Antimicrobial activity against Enterobacter cloacae 34654 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482387Stability in 25% mouse serum assessed as peptide-13 level at 75 ug/ml after 30 mins by MALDI-TOF-MS analysis2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482370Antibacterial activity against Escherichia coli BL21 AI after 20 hrs by broth microdilution assay2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482407Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482393Toxicity in human erythrocytes assessed as hemolytic activity at 600 ug/ml after 1 hr2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482383Antimicrobial activity against Enterobacter cloacae Ha088 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482363Antimicrobial activity against Escherichia coli 70419002 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482378Antimicrobial activity against Acinetobacter baumannii ICB 14072 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482380Antimicrobial activity against Acinetobacter baumannii ICB 9250 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482376Antimicrobial activity against Klebsiella pneumoniae ATCC 27799 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482365Antimicrobial activity against Escherichia coli Neumann after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482375Antimicrobial activity against Klebsiella pneumoniae ATCC 12657 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482394Cytotoxicity against human HeLa cells at 600 ug/ml after 24 hrs by MTT assay2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482390Stability in 25% mouse serum assessed as compound remaining at 75 ug/ml after 2 hrs by MALDI-TOF-MS analysis2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482411Antimicrobial activity against Stenotrophomonas ICB 7789 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482367Antimicrobial activity against Escherichia coli 455/7 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482399Antimicrobial activity against Stenotrophomonas ICB 308054 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482395Cytotoxicity against human SH-SY5Y cells at 600 ug/ml after 24 hrs by MTT assay2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482386Stability in 25% mouse serum assessed as peptide-12 level at 75 ug/ml after 30 mins by MALDI-TOF-MS analysis2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482396Antimicrobial activity against Enterobacter cloacae Ha89 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482400Antimicrobial activity against Stenotrophomonas ICB 7569 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482379Antimicrobial activity against Acinetobacter baumannii ICB 14073 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482368Antimicrobial activity against Escherichia coli 8474 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482377Antimicrobial activity against Acinetobacter baumannii ICB 14067 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482398Antimicrobial activity against Proteus vulgaris ICB 9095 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482392Stability in 100% mouse serum assessed as half life at 75 ug/ml by MALDI-TOF-MS analysis2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482364Antimicrobial activity against Escherichia coli 70502001 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482405Antimicrobial activity against Pseudomonas aeruginosa 60909001 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482403Antimicrobial activity against Pseudomonas aeruginosa 70108001 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482408Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482369Antimicrobial activity against Klebsiella pneumoniae DSM 681 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482406Antimicrobial activity against Pseudomonas aeruginosa 60811001 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482404Antimicrobial activity against Pseudomonas aeruginosa 61118003 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482381Antimicrobial activity against Acinetobacter baumannii M17 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482389Stability in 25% mouse serum assessed as peptide-13 level at 75 ug/ml after 2 hrs by MALDI-TOF-MS analysis2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482384Antimicrobial activity against Enterobacter cloacae Ha089 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482412Drug uptake in Escherichia coli BL21 AI assessed as intracellular localization at 30 ug/ml after 20 mins by confocal fluorescence microscopy2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482373Antimicrobial activity against Klebsiella pneumoniae 63 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482401Antimicrobial activity against Escherichia coli 70430001 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482371Antibacterial activity against Micrococcus luteus ATCC 10240 after 20 hrs by broth microdilution assay2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482385Antimicrobial activity against Enterobacter cloacae Ha185 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482391Antimicrobial activity against Klebsiella pneumoniae 57 USA after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482388Stability in 25% mouse serum assessed as peptide-12 level at 75 ug/ml after 2 hrs by MALDI-TOF-MS analysis2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482402Antimicrobial activity against Escherichia coli 70329001 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482410Antimicrobial activity against Pseudomonas aeruginosa DSM 3227 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482366Antimicrobial activity against Escherichia coli 205024 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482374Antimicrobial activity against Klebsiella pneumoniae 8085 after 20 hrs by broth microdilution method2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
AID482372Stability in 25% mouse serum assessed as half life at 75 ug/ml by MALDI-TOF-MS analysis2010Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (26)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's22 (84.62)24.3611
2020's4 (15.38)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.95

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.95 (24.57)
Research Supply Index3.30 (2.92)
Research Growth Index6.40 (4.65)
Search Engine Demand Index30.30 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.95)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.85%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other25 (96.15%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ethylene glycol
Ethylene Glycol: A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.. ethanediol : Any diol that is ethane or substituted ethane carrying two hydroxy groups.. ethylene glycol : A 1,2-glycol compound produced via reaction of ethylene oxide with water.		7.1310ethanediol;
glycol		metabolite;
mouse metabolite;
solvent;
toxin
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		2.1310
6-carboxyfluorescein
6-carboxyfluorescein: originally sold as 6-carboxyfluorescein, but commercial product is a mixture of two isomers; correct name is 5(6)-carboxyfluorescein		2.1310monocarboxylic acid
proline
Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.		4.1240amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
bactenecin
bactenecin: from bovine neutrophils		3.9230
dimyristoylphosphatidylcholine
1,2-di-O-myristoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).. dimyristoyl phosphatidylcholine : A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).		2.06101,2-diacyl-sn-glycero-3-phosphocholine;
phosphatidylcholine 28:0;
tetradecanoate ester		antigen;
mouse metabolite
tylosin b
[no description available]		2.4110
drosocin
drosocin: amino acid sequence given in first source for drosocin and its precursor; GenBank Z21942		2.4820
pyrrhocoricin protein, pyrrhocoris apterus
pyrrhocoricin protein, Pyrrhocoris apterus: a 20-residue proline-rich peptide carrying an O-glycosylated substitution; from the sap-sucking bug Pyrrhocoris apterus; active against Gram-negative bacteria; amino acid sequence given in first source		2.1310
apidaecin ib
apidaecin: isolated from lymph fluid of honeybee; amino acid sequence given in first source; not antibiotic, since it does not come from microorganism		3.7190
tylosin
[no description available]		2.4110
ConditionIndicatedRelationship StrengthStudiesTrials
Extravascular Hemolysis
[description not available]		02.0510
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.0510
Infections, Klebsiella
[description not available]		02.110
Klebsiella Infections
Infections with bacteria of the genus KLEBSIELLA.		02.110
Bacterial Disease
[description not available]		02.1110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.7930
Bacterial Infections
Infections by bacteria, general or unspecified.		02.1110
Infections, Staphylococcal
[description not available]		02.1310
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.1310
Blood Poisoning
[description not available]		02.520
E coli Infections
[description not available]		02.520
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.		02.520
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.		02.520
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