Page last updated: 2024-11-13
melectin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
melectin: isolated from the venom of the cleptoparasitic bee Melecta albifrons [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 49777299 |
| CHEMBL ID | 1240733 |
| MeSH ID | M0528093 |
Synonyms (3)
| Synonym |
|---|
| melectin |
| gflsilkkvlpkvmahmk-nh2 |
| CHEMBL1240733 |
Research Excerpts
Overview
Melectin is an α-helical structure that binds to the bacterial membrane via electrostatic interactions. Melectin kills bacteria in a short time by bacterial membrane targeting.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Melectin is an α-helical structure that binds to the bacterial membrane via electrostatic interactions and kills bacteria in a short time by bacterial membrane targeting." | ( Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties. Asandei, A; Choi, JY; Ko, SJ; Lee, SC; Luchian, T; Park, E; Park, Y; Seo, CH, 2020) | 1.55 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (3)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID511696 | Therapeutic index, ratio of TC50 for human CEM-SS cells infected with HIV1 3B to EC50 for HIV1 3B infected in human CEM-SS cells | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. |
| AID511695 | Cytotoxicity against human CEM-SS cells infected with HIV1 3B after 6 days by XTT assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. |
| AID511694 | Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 23.21
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.21) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||