Page last updated: 2024-11-12
spinigerin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
spinigerin: antimicrobial peptide isolated from the fungus-growing termite Pseudacanthotermes spiniger (heterometabole insect, Isoptera); GenBank P82357 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 16209973 |
| CHEMBL ID | 1240720 |
| MeSH ID | M0390463 |
Synonyms (3)
| Synonym |
|---|
| hvdkkvadkvlllkqlrimrlltrl |
| spinigerin |
| CHEMBL1240720 |
Research Excerpts
Overview
Spinigerin is a linear antibacterial peptide derived from a termite insect.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Spinigerin is a linear antibacterial peptide derived from a termite insect. " | ( Solution structure of termite-derived antimicrobial peptide, spinigerin, as determined in SDS micelle by NMR spectroscopy. Hahm, KS; Hong, JE; Kim, JI; Kim, Y; Lee, KH; Shin, SY; Yang, ST, 2003) | 2 |
Actions
| Excerpt | Reference | Relevance |
|---|---|---|
| "Spinigerin displays good lytic activities against Gram-positive and Gram-negative bacteria, but has no hemolytic activities against human erythrocytes." | ( Solution structure of termite-derived antimicrobial peptide, spinigerin, as determined in SDS micelle by NMR spectroscopy. Hahm, KS; Hong, JE; Kim, JI; Kim, Y; Lee, KH; Shin, SY; Yang, ST, 2003) | 1.28 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (3)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID511694 | Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. |
| AID511696 | Therapeutic index, ratio of TC50 for human CEM-SS cells infected with HIV1 3B to EC50 for HIV1 3B infected in human CEM-SS cells | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. |
| AID511695 | Cytotoxicity against human CEM-SS cells infected with HIV1 3B after 6 days by XTT assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.50
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.50) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||