| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase. | 2.05 | 1 | 0 | azide;
pyrimidine 2',3'-dideoxyribonucleoside | antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor |
xylose
xylopyranose: structure in first source | 2.05 | 1 | 0 | D-xylose | |
(4-24)-ply(a)
peptide-Gly-Leu-amide: 21-amino acid peptide from skin secretion of Xenopus laevis; amino acid sequence given in first source | 2.05 | 1 | 0 | | |
drosocin
drosocin: amino acid sequence given in first source for drosocin and its precursor; GenBank Z21942 | 2.05 | 1 | 0 | | |
parasin i
[no description available] | 2.05 | 1 | 0 | | |
ropocamptide
ropocamptide: from granulocytes & keratinocytes, precursor to cathelicidins; MW 16-18 kDa; GenBank AJ224927 (eCATH-1). cathelicidin : A group of small, cationic polypeptides (consisting of 12-97 amino acids) that are found in humans and other species, including farm animals (E.g. cattle, horses, pigs, sheep etc). They show a broad spectrum of antimicrobial activity against bacteria, enveloped viruses and fungi. | 2.05 | 1 | 0 | | |
spinigerin
spinigerin: antimicrobial peptide isolated from the fungus-growing termite Pseudacanthotermes spiniger (heterometabole insect, Isoptera); GenBank P82357 | 2.05 | 1 | 0 | | |
isracidin
isracidin: the N-terminal segment (1-23) of alpha(S1)-casein B; amino acid sequence given in first source | 2.05 | 1 | 0 | | |
melectin
melectin: isolated from the venom of the cleptoparasitic bee Melecta albifrons | 2.05 | 1 | 0 | | |