Page last updated: 2024-10-24

sympathetic neuron projection extension

Definition

Target type: biologicalprocess

Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:BHF, GOC:rl, PMID:22790009]

Sympathetic neuron projection extension is a complex process that involves the coordinated action of multiple cellular pathways and signaling molecules. It begins with the differentiation of sympathetic neurons from neural progenitor cells in the neural tube. These neurons then migrate to their final destinations in the peripheral nervous system. Once in place, they extend axons, which are long, slender projections that transmit nerve impulses. Axon extension is guided by a variety of cues, including chemoattractants and chemorepellents, as well as cell-cell interactions. These cues trigger a cascade of intracellular signaling events that ultimately lead to the polymerization of actin and microtubule filaments, which are the structural components of axons. As the axon grows, it forms branches that connect to target cells. These connections, known as synapses, allow sympathetic neurons to transmit signals to other cells, such as smooth muscle cells, glands, and other neurons. Sympathetic neuron projection extension is essential for the proper functioning of the sympathetic nervous system, which controls a wide range of physiological processes, including heart rate, blood pressure, and digestion. Disruptions in sympathetic neuron projection extension can lead to a variety of neurological disorders.'
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Proteins (2)

ProteinDefinitionTaxonomy
Protein S100-BA protein S100-B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04271]Homo sapiens (human)
Neuropilin-1A neuropilin-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14786]Homo sapiens (human)

Compounds (4)

CompoundDefinitionClassesRoles
pentamidinepentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.

Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
aromatic ether;
carboxamidine;
diether
anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
3-methyl-n,n-diethyl-p-phenylenediamine3-methyl-N,N-diethyl-p-phenylenediamine: RN given refers to parent cpd; structure
ala-thr-trp-leu-pro-pro-arg
EG00229benzothiadiazole;
dicarboxylic acid monoamide;
L-arginine derivative;
secondary carboxamide;
sulfonamide;
thiophenes
angiogenesis inhibitor;
antineoplastic agent;
neuropilin receptor antagonist