dorsal root ganglion morphogenesis

Definition

Target type: biologicalprocess

The developmental process by which a dorsal root ganglion is generated and organized. [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100]

Dorsal root ganglia (DRG) morphogenesis is a complex process involving the coordinated interplay of signaling molecules, cell-cell interactions, and transcriptional regulation. It begins with the specification of neural crest cells (NCCs), a multipotent cell population that gives rise to a diverse array of cell types, including DRG neurons. As NCCs migrate from the neural tube to the dorsal aspect of the developing spinal cord, they encounter signals from surrounding tissues, including the notochord and the floor plate, which induce their commitment to a sensory neuron fate. One of the key signaling pathways involved in DRG formation is the Wnt pathway, which promotes the expression of transcription factors like Sox10 and Pax6, which are essential for DRG development. Following their commitment, NCCs undergo a series of cell division, migration, and differentiation events to form the DRG. The DRG is characterized by its unique architecture, consisting of a central cluster of neurons surrounded by satellite glial cells. Axons from the DRG neurons extend both peripherally to innervate sensory organs and centrally to synapse within the spinal cord. The formation of this complex structure requires precise spatial and temporal regulation of gene expression, and any disruption in this process can lead to congenital defects in the peripheral nervous system. '
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Proteins (1)

Compounds (2)