4-azidophenacyl bromide

Description

4-Azidophenacyl bromide is a versatile synthetic reagent used in organic chemistry. It is a potent electrophile that can be used to introduce azide groups into various molecules through nucleophilic substitution reactions. 4-Azidophenacyl bromide is known for its ability to react with various nucleophiles, including amines, alcohols, and thiols, forming azide-containing compounds. Its synthesis often involves the reaction of 4-bromophenacyl bromide with sodium azide. Due to the azide functional group's reactivity, 4-Azidophenacyl bromide is often used in click chemistry reactions, which involve the formation of triazoles from azides and alkynes. This reactivity has made it a valuable tool for the development of bioconjugation methods, drug discovery, and materials science. The compound is also studied for its potential applications in photoaffinity labeling, which involves using light to covalently attach a molecule to a target protein. This technique is used to identify and characterize protein-protein interactions. Research on 4-Azidophenacyl bromide continues to explore its diverse applications in chemical synthesis, bioconjugation, and other fields.'

4-azidophenacyl bromide: photolabile bifunctional reagent; bromide is an integral part of cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]