Assay ID | Title | Year | Journal | Article |
AID1322959 | Binding affinity to human plasma wild type TTR assessed as dissociation constants for first binding site of TTR by isothermal titration calorimetric method | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. |
AID1386029 | Binding affinity to purified human transthyretin assessed as protein occupancy at 10 uM incubated for 6 hrs in pH 7.4 PBS buffer in presence of 600 uM albumin by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386024 | Binding affinity to human serum albumin assessed as compound level bound to protein at 30 uM measured immediately after gel filtration | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386037 | In-vivo binding affinity to transthyretin in beagle dog serum assessed as protein occupancy 20 mg/kg/day dosed daily dosed as single administration via oral gavage | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386011 | Binding affinity to transthyretin in whole human serum assessed as protein occupancy at 5 uM after 72 hrs by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386027 | Binding affinity to transthyretin (unknown origin) assessed as compound to TTR molar ratio at 5 uM measured after 24 hrs by gel filtration/dialysis assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386025 | Binding affinity to human serum albumin assessed as compound level bound to protein at 30 uM measured 124 hrs after dialysis | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1385999 | Binding affinity to transthyretin in dog serum assessed as protein stabilization at 10 uM by by Western blot | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386019 | Binding affinity to transthyretin (unknown origin) in human serum assessed as protein stabilization at 10 uM in pH 7.4 urea buffer by Western blot | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386028 | Binding affinity to purified human transthyretin assessed as protein occupancy at 10 uM incubated for 6 hrs in pH 7.4 PBS buffer by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386022 | Binding affinity to transthyretin in whole human serum assessed as protein occupancy at 20 uM after 72 hrs by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386009 | Binding affinity to transthyretin in human serum assessed as protein occupancy at 2:1 compound to TTR ratio after 72 hrs by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1896523 | Binding affinity to human TTR incubated for 20 mins by fluorescence polarization assay | 2022 | Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22
| Enhancing the Safety and Efficacy of PSMA-Based Small-Molecule Drug Conjugates by Linker Stabilization and Conjugation to Transthyretin Binding Ligand. |
AID1386010 | Binding affinity to transthyretin in human serum assessed as protein stabilization at 2:1 compound to TTR ratio after 72 hrs by Western blot | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386006 | Binding affinity to transthyretin (unknown origin) assessed as free enthalpy changes by ITC method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386026 | Binding affinity to transthyretin (unknown origin) assessed as compound to TTR molar ratio at 5 uM measured after 6 hrs by gel filtration/dialysis assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386003 | Potency index, ratio of Kd for tolcapone to Kd for test compound for binding affinity to transthyretin (unknown origin) by ITC method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1810836 | Disruption of retional-induced bacterially expressed MBP-tagged RBP4-TTR (unknown origin) protein-protein interaction measured by d2 dye based HTFR assay | 2021 | Journal of medicinal chemistry, 07-08, Volume: 64, Issue:13
| Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Th |
AID1386036 | In-vivo binding affinity to transthyretin in beagle dog serum assessed as protein occupancy measured at 1 hr post dose on day 7 at 50 to 200 mg/kg/day dosed daily via oral gavage for 7 days by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386016 | Binding affinity to transthyretin (unknown origin) in human serum assessed as protein occupancy at 10 uM by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386007 | Binding affinity to transthyretin (unknown origin) assessed as free TdeltaS changes by ITC method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386008 | Binding affinity to transthyretin (unknown origin) in pH 7.4 PBS buffer assessed as protein occupancy at 1:1 compound to TTR ratio by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386023 | Binding affinity to transthyretin in whole human serum assessed as protein stabilization at 20 uM after 72 hrs by Western blot | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386033 | Binding affinity to transthyretin in dog serum assessed as protein occupancy at 10 uM by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1810838 | Displacement of [3H]-all trans retinol from human urine biotinylated RBP4 incubated for 16 hrs measured by Scintillation Proximity Assay | 2021 | Journal of medicinal chemistry, 07-08, Volume: 64, Issue:13
| Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Th |
AID1386004 | Potency index, ratio of Kd for diflunisal to Kd for test compound for binding affinity to transthyretin (unknown origin) by ITC method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386021 | Binding affinity to transthyretin in whole human serum assessed as protein stabilization at 5 uM after 72 hrs by Western blot | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386030 | Binding affinity to purified human transthyretin assessed as protein occupancy at 10 uM incubated for 6 hrs in pH 7.4 PBS buffer in presence of 25 uM transferrin by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386001 | Binding affinity to human serum albumin by ITC method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386034 | In-vivo binding affinity to transthyretin in beagle dog serum assessed as protein occupancy at 50 to 200 mg/kg/day dosed daily via oral gavage for 7 days by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386005 | Binding affinity to transthyretin (unknown origin) assessed as free energy changes by ITC method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386031 | Binding affinity to purified human transthyretin assessed as protein occupancy at 10 uM incubated for 6 hrs in pH 7.4 PBS buffer in presence of 5 uM fibrinogen by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1810837 | Binding affinity to human plasma TTR tetramer assessed as displacement of diclofenac-coupled FITC by fluorescence polarization assay | 2021 | Journal of medicinal chemistry, 07-08, Volume: 64, Issue:13
| Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Th |
AID1386000 | Binding affinity to transthyretin (unknown origin) by ITC method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386032 | Binding affinity to purified human transthyretin assessed as protein occupancy at 10 uM incubated for 6 hrs in pH 7.4 PBS buffer in presence of 70 uM IgG by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386015 | Dissociation constant, pKa of the compound | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1386038 | In-vivo binding affinity to transthyretin in beagle dog serum assessed as protein occupancy 5 mg/kg/day dosed daily dosed as single administration via oral gavage | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID1322958 | Binding affinity to human plasma wild type TTR assessed as dissociation constants for second binding site of TTR by isothermal titration calorimetric method | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. |
AID1386035 | In-vivo binding affinity to transthyretin in beagle dog serum assessed as protein occupancy measured on day 7 at 50 to 200 mg/kg/day dosed daily via oral gavage for 7 days by fluorescent probe exclusion assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. |
AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2013 | Proceedings of the National Academy of Sciences of the United States of America, Jun-11, Volume: 110, Issue:24
| AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |