Page last updated: 2024-09-05

xv 459 and isoxazoles

xv 459 has been researched along with isoxazoles in 13 studies

Compound Research Comparison

Studies (xv 459)	Trials (xv 459)	Recent Studies (post-2010) (xv 459)	Studies (isoxazoles)	Trials (isoxazoles)	Recent Studies (post-2010) (isoxazoles)
15	2	0	8,633	900	3,337

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (61.54)	18.2507
2000's	5 (38.46)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bozarth, J; DeGrado, W; Forsythe, M; Hussain, M; Kapil, R; Lorelli, W; Mousa, SA; Olson, RE; Reilly, TM; Sielecki, TM; Thoolen, MJ; Wexler, R; Wityak, J; Xue, CB	1
Aungst, BJ; Hussain, MA; Kapil, R; Mousa, SA	1
Bozarth, J; Levine, B; Mousa, SA; Youssef, A	1
Hantgan, RR; Mousa, SA	1
Bozarth, JM; Forsythe, MS; Friedman, PA; Lorelli, W; Mousa, SA; Reilly, TM; Slee, AM; Thoolen, MJ	1
Hussain, MA; Mousa, SA; Mu, DX	1
Kapil, R; Mousa, SA; Mu, DX	1
Barrett, JS; Bozarth, JM; Brown, F; Corjay, MH; Ebling, WF; Kapil, R; Mousa, SA; Padovani, P; Pieniaszek, HJ; Reilly, TM; Yu, J	1
Christ, DD; Diamond, S; Gan, L; Mutlib, AE; Nemeth, G; Shockcor, J; Way, R	1
Cain, VA; Ebling, W; Fossler, MJ; Kornhauser, DM; Ma, S; Mondick, JT; Pieniaszek, HJ; Sy, SK	1
Barrett, JS; Ebling, WF; Fossler, MJ; Garner, D; Kornhauser, D; Ma, S; Mondick, J; Pieniaszek, HJ; Quon, CY	1
Barrett, YC; Davidson, AF; Olson, RE; Pieniaszek, HJ; Pinto, DJ; Reilly, TM; Walton, HL	1
Ahmad, S; Mousa, SA	1

Trials

2 trial(s) available for xv 459 and isoxazoles

Article	Year
Safety, tolerability, pharmacokinetics, and time course of pharmacologic response of the active metabolite of roxifiban, XV459, a glycoprotein IIb/IIIa antagonist, following oral administration in healthy volunteers. Journal of clinical pharmacology, 2002, Volume: 42, Issue:7 Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Amidines; Amino Acids; Area Under Curve; Aspirin; Bleeding Time; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Hydrolysis; Isoxazoles; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Time Factors	2002
Integrated pharmacokinetic/pharmacodynamic model of XV459, a potent and specific GPIIb/IIIa inhibitor, in healthy male volunteers. Journal of clinical pharmacology, 2002, Volume: 42, Issue:12 Topics: Administration, Oral; Aged; Amidines; Amino Acids; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Half-Life; Humans; Isoxazoles; Middle Aged; Models, Biological; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs	2002

Article

Year

Safety, tolerability, pharmacokinetics, and time course of pharmacologic response of the active metabolite of roxifiban, XV459, a glycoprotein IIb/IIIa antagonist, following oral administration in healthy volunteers.

Journal of clinical pharmacology, 2002, Volume: 42, Issue:7

Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Amidines; Amino Acids; Area Under Curve; Aspirin; Bleeding Time; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Hydrolysis; Isoxazoles; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Time Factors

2002

Integrated pharmacokinetic/pharmacodynamic model of XV459, a potent and specific GPIIb/IIIa inhibitor, in healthy male volunteers.

Journal of clinical pharmacology, 2002, Volume: 42, Issue:12

Topics: Administration, Oral; Aged; Amidines; Amino Acids; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Half-Life; Humans; Isoxazoles; Middle Aged; Models, Biological; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs

2002

Other Studies

11 other study(ies) available for xv 459 and isoxazoles

Article	Year
Novel nonpeptide antiplatelet glycoprotein IIb/IIIa receptor antagonist, DMP754: receptor binding affinity and specificity. Coronary artery disease, 1996, Volume: 7, Issue:10 Topics: Amino Acids; Animals; Cell Adhesion; Dogs; Fibrinogen; Guinea Pigs; Humans; Integrins; Isoxazoles; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Rats; Sensitivity and Specificity; Species Specificity	1996
Intranasal absorption of the platelet glycoprotein IIb/IIIa receptor antagonist, DMP 755, and the effect of anesthesia on nasal bioavailability. Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:12 Topics: Absorption; Administration, Intranasal; Amino Acids; Anesthesia; Animals; Biological Availability; Dogs; Female; Isoxazoles; Male; Nasal Mucosa; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs	1997
Oral antiplatelet efficacy of the platelet GPIIb/IIIa antagonist, DMP754 in non-human primates. Thrombosis research, 1998, Mar-01, Volume: 89, Issue:5 Topics: Administration, Oral; Amino Acids; Animals; Blood Platelets; Dogs; Drug Evaluation, Preclinical; Humans; Isoxazoles; Kinetics; Papio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex	1998
Inhibition of platelet-mediated clot retraction by integrin antagonists. Thrombosis research, 1998, Mar-15, Volume: 89, Issue:6 Topics: Amino Acids; Antibodies, Monoclonal; Blood Platelets; Humans; Immunoglobulin Fab Fragments; Isoxazoles; Mesylates; Peptides, Cyclic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex	1998
Antiplatelet efficacy of XV459, a novel nonpeptide platelet GPIIb/IIIa antagonist: comparative platelet binding profiles with c7E3. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:3 Topics: Amino Acids; Animals; Antibodies, Monoclonal; Blood Platelets; Dogs; Fibrinogen; Humans; Isoxazoles; Papio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex	1998
Intranasal antiplatelet/antithrombotic efficacy of a novel platelet GPIIB/IIIA receptor antagonist DMP755. Thrombosis research, 1998, Nov-01, Volume: 92, Issue:3 Topics: Administration, Intranasal; Administration, Oral; Amino Acids; Animals; Biological Availability; Carotid Arteries; Dogs; Female; Femoral Artery; Fibrinolytic Agents; Injections, Intravenous; Isoxazoles; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis	1998
Intravenous and oral antithrombotic efficacy of the novel platelet GPIIb/IIIa antagonist roxifiban (DMP754) and its free acid form, XV459. Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:10 Topics: Administration, Oral; Amidines; Amino Acids; Animals; Bleeding Time; Disease Models, Animal; Dogs; Electroshock; Female; Femoral Artery; Humans; Injections, Intravenous; Isoxazoles; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis	1999
Disposition and exposure of the fibrinogen receptor antagonist XV459 on alphaIIBbeta3 binding sites in the guinea pig. Biopharmaceutics & drug disposition, 1999, Volume: 20, Issue:6 Topics: Amino Acids; Animals; Area Under Curve; Binding Sites; Binding, Competitive; Guinea Pigs; Humans; Infusions, Intravenous; Isoxazoles; Male; Metabolic Clearance Rate; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Species Specificity; Structure-Activity Relationship	1999
Mass spectrometric and NMR characterization of metabolites of roxifiban, a potent and selective antagonist of the platelet glycoprotein IIb/IIIa receptor. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:11 Topics: Amidines; Amino Acids; Animals; Cardiovascular Agents; Chromatography, High Pressure Liquid; Dogs; Feces; Gas Chromatography-Mass Spectrometry; Humans; Isoxazoles; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Platelet Glycoprotein GPIIb-IIIa Complex; Rats; Thrombosis	2000
A double antibody radioimmunoassay for the determination of XV459, the active hydrolysis metabolite of roxifiban, in human plasma. Journal of pharmaceutical and biomedical analysis, 2003, Jan-01, Volume: 30, Issue:5 Topics: Amidines; Amino Acids; Animals; Antibodies; Binding Sites; Humans; Isoxazoles; Linear Models; Rabbits; Radioimmunoassay	2003
Platelet GPIIb/IIIa antagonist, XV459, in heparin-induced thrombocytopenia. American journal of hematology, 2007, Volume: 82, Issue:4 Topics: Amino Acids; Cells, Cultured; Heparin; Humans; Isoxazoles; Kruppel-Like Transcription Factors; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Repressor Proteins; Sensitivity and Specificity; Thrombocytopenia	2007