BI-32169: a bicyclic 19-peptide with strong glucagon receptor antagonist activity from Streptomyces sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 44584360 |
| CHEMBL ID | 526383 |
| MeSH ID | M0475611 |
| Synonym |
|---|
| bdbm50269738 |
| bi-32169 |
| CHEMBL526383 , |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Glucagon receptor | Homo sapiens (human) | IC50 (µMol) | 0.4400 | 0.0066 | 0.4017 | 2.6000 | AID333259 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| glucagon receptor activity | Glucagon receptor | Homo sapiens (human) |
| guanyl-nucleotide exchange factor activity | Glucagon receptor | Homo sapiens (human) |
| peptide hormone binding | Glucagon receptor | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| endosome | Glucagon receptor | Homo sapiens (human) |
| plasma membrane | Glucagon receptor | Homo sapiens (human) |
| membrane | Glucagon receptor | Homo sapiens (human) |
| plasma membrane | Glucagon receptor | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID333259 | Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA | 2004 | Journal of natural products, Sep, Volume: 67, Issue:9 | BI-32169, a bicyclic 19-peptide with strong glucagon receptor antagonist activity from Streptomyces sp. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||