Page last updated: 2024-12-07

s 2366

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

S 2366: chromogenic substrate for Factor XI in plasma [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	126364
SCHEMBL ID	1418691
MeSH ID	M0119798

Synonyms (18)

Synonym
s 2366
(2s)-n-[(2s)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]-1-[(2s)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
72194-57-1
pglu-pro-arg-pna
pyroglutamyl-prolyl-arginine-4-nitroanilide
s-2366 ,
l-agrininamide, 5-oxo-l-prolyl-l-prolyl-n-(4-nitrophenyl)-
(2s)-5-carbamimidamido-n-(4-nitrophenyl)-2-{[(2s)-1-{[(2s)-5-oxopyrrolidin-2-yl]carbonyl}pyrrolidin-2-yl]formamido}pentanamide hydrochloride
glu-pro-arg-pna
hepsin chromogenic substrate
bdbm13573
l-pyroglutamyl-l-prolyl-l-argininep-nitroaniline
chromogenic substrate s-2366
l-pyroglutamyl-l-prolyl-l-arginine-p-nitroaniline
SCHEMBL1418691
DTXSID70992908
n-[5-carbamimidamido-1-(4-nitroanilino)-1-oxopentan-2-yl]-1-(5-hydroxy-3,4-dihydro-2h-pyrrole-2-carbonyl)pyrrolidine-2-carboximidic acid
pyr-ro-rg-na

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (17.65)	18.7374
1990's	8 (47.06)	18.2507
2000's	3 (17.65)	29.6817
2010's	3 (17.65)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	21.58 (24.57)
Research Supply Index	2.89 (2.92)
Research Growth Index	4.58 (4.65)
Search Engine Demand Index	19.78 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (21.58)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.05	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
glycine [no description available]	2.02	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
4-aminobenzamidine 4-aminobenzamidine: a urokinase inhibitor; inhibits acrosin; structure given in first source	2.17	1
benzamidine benzamidine: RN given refers to parent cpd. benzamidine : A carboxamidine that is benzene carrying an amidino group.	2.17	1	benzenes; carboxamidine	serine protease inhibitor
zinc chloride zinc chloride: RN given refers to parent cpd. zinc dichloride : A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.	2.05	1	inorganic chloride; zinc molecular entity	astringent; disinfectant; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; Lewis acid
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	2.52	2	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
pyrrolidonecarboxylic acid Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.. 5-oxo-L-proline : An optically active form of 5-oxoproline having L-configuration.	4.19	17	5-oxoproline; L-proline derivative; non-proteinogenic L-alpha-amino acid	algal metabolite
1-carboxyglutamic acid 1-Carboxyglutamic Acid: Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.	1.98	1
mci 9038 [no description available]	2.17	1	peptide
dansyl fluoride dansyl fluoride: structure in second source	2.02	1
val-leu-arg-p-nitroanilide [no description available]	1.98	1
prolyl-phenylalanyl-arginine-4-nitroanilide prolyl-phenylalanyl-arginine-4-nitroanilide: chromogenic cpd	1.98	1
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.02	1	cysteinium	fundamental metabolite
kaolinite Kaolin: The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: high ridge), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed). kaolin : An aluminosilicate soft white mineral named after the hill in China (Kao-ling) from which it was mined for centuries. In its natural state kaolin is a white, soft powder consisting principally of the mineral kaolinite, and varying amounts of other minerals such as muscovite, quartz, feldspar, and anatase. It is used in the manufacture of china and porcelain and also widely used in the production of paper, rubber, paint, drying agents, and many other products.	1.98	1	aluminosilicate mineral; mixture	antidiarrhoeal drug; excipient

Condition	Relationship Strength	Studies
Deficiency, Factor 11 [description not available]	1.96	1
Coagulation Factor 12 Deficiency [description not available]	1.98	1
Christmas Disease [description not available]	1.98	1
Hemophilia B A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)	1.98	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.38	2
Female Genital Neoplasms [description not available]	1.98	1
Genital Neoplasms, Female Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).	1.98	1
Thromboembolism Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.	1.98	1
Endotoxemia A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.	1.99	1
Blood Clot [description not available]	1.97	1
Thrombosis Formation and development of a thrombus or blood clot in the blood vessel.	1.97	1

chemdatabank.com