Deficiency, Factor 11

A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia.

Synonym
Hemophilia C
Deficiency, Factor XI
Deficiency, Factor Eleven
Plasma Thromboplastin Antecedent Deficiency
Factor XI Deficiency
Deficiency, Factor 11
Rosenthal's Syndrome
Rosenthal Syndrome
Factor 11 Deficiency
Factor Eleven Deficiency

Excerpt	Reference
"Inherited factor XI deficiency is an injury-related bleeding disorder that is rare in most populations except for Jews, in whom 2 mutations, a stop mutation in exon 5 (type II) and a missense mutation in exon 9 (type III), predominate."	( Bauduer, F; Ducout, L; Peretz, H; Rosenberg, N; Seligsohn, U; Yatuv, R; Zivelin, A, 2002)
"Factor XI deficiency is a rare inherited coagulation disorder."	( Diego Fernández, Pd; García Fernández, JR; López Berenguel, F; Moreno Madrid, F; Sánchez Forte, M, 2002)
"Factor XI deficiency is a rare, hereditary bleeding disorder associated with a trauma-related bleeding tendency, caused by insufficient generation of the thrombin activatable fibrinolysis inhibitor (TAFI) evoking increased fibrinolysis."	( Dirkmann, D; Görlinger, K; Hanke, AA; Peters, J, 2007)
"Factor XI deficiency is a rare disease found predominantly in Ashkenazi Jews."	( Alvarez, MT; Hernández-Navarro, F; Jimenez-Yuste, V; Martín-Salces, M; Quintana, M, 2010)
"Factor XI deficiency is a rare coagulopathy occurring primarily in Ashkenazi Jews, and is associated with bleeding diathesis."	( Levi, E; Shimony, A; Zahger, D, 2009)
"Factor XI deficiency is a rare bleeding disorder that is more commonly found in Ashkenazi Jews."	( James, AH; Price, TM; Saleh, OA; Shah, AA; Steward, RG, 2012)
"Factor XI deficiency is associated with significant bleeding in the setting of trauma and surgery."	( Bendapudi, PK; Cameron, DE; Fitzsimons, MG; Leaf, RK; Mack, J; Shen, T, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	92 (54.76)	23.3326
1990's	17 (10.12)	12.5806
2000's	26 (15.48)	18.1394
2010's	27 (16.07)	28.8240
2020's	6 (3.57)	9.53

Drug	Relationship Strength	Studies
chlorine	low	3
hydrochloric acid	low	1
aminocaproic acid	low	1
glycine	low	2
iodine	low	1
1-propanol	low	1
mercaptoethanol	low	1
aminopropionitrile	low	1
aspirin	low	5
guaifenesin	low	1
isoflurane	low	1
2-propanol	low	1
phenindione	low	1
procainamide	low	2
ticlopidine	low	1
tranexamic acid	low	12
prednisolone	low	1
thyroxine	low	1
prednisone	low	3
serine	low	1
adenosine diphosphate	low	2
edetic acid	low	1
tyrosine	low	1
leucine	low	2
phenylalanine	low	2
asparagine	low	1
valine	low	2
threonine	low	1
tryptophan	low	1
isoleucine	low	1
arginine	low	4
tromethamine	low	1
pyrrolidonecarboxylic acid	low	1
testosterone enanthate	low	1
citrulline	low	1
betamethasone	low	1
thorium dioxide	low	1
ferric chloride	low	3
trolamine salicylate	low	1
clopidogrel	low	1
trazodone hydrochloride	low	1
glucose, (beta-d)-isomer	low	1
fluindione	low	1
fibrinogen	low	17
s 2366	low	1
fibrin	low	10
oxytocin	low	1
enclomiphene	low	1
dinoprost	low	1
vitamin k semiquinone radical	low	2
ellagic acid	low	2
fondaparinux	low	1
15-keto-13,14-dihydroprostaglandin f2alpha	low	1
phenylephrine hydrochloride	low	1
vitamin k 1	low	1
deamino arginine vasopressin	low	10
strontium	low	1
cysteine	low	1
selenium	low	1
oxalates	low	1
acid phosphatase	low	3
ristocetin	low	2
fibrinopeptide a	low	2
natriuretic peptide, brain	low	1
dicumarol	low	2
warfarin	low	4
kaolinite	low	10
hyaluronoglucosaminidase	low	1
vitamin b 12	low	1
ecallantide	low	3
thromboplastin	low	37
concanavalin a	low	1

Protein Targets (623)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	14	0	0	14
GLI family zinc finger 3	13	0	0	13
AR protein	16	0	0	16
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
retinoid X nuclear receptor alpha	6	0	0	6
estrogen nuclear receptor alpha	22	0	0	22
peroxisome proliferator-activated receptor delta	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	5	0	0	5
thyroid hormone receptor beta isoform a	7	0	0	7
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
lamin isoform A-delta10	15	0	0	15
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Glutamate receptor 2	8	0	0	8
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	3	0	0	3
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	2	0	2
Mu-type opioid receptor	0	0	1	1
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	2	0	0	2
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Chain A, PLASMINOGEN	0	0	2	2
Chain A, PLASMINOGEN	0	0	2	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	6	0	0	6
Chain A, Apolipoprotein	0	0	1	1
15-lipoxygenase, partial	2	0	0	2
ATAD5 protein, partial	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
EWS/FLI fusion protein	8	0	0	8
nonstructural protein 1	4	0	0	4
glucocorticoid receptor [Homo sapiens]	17	0	0	17
arylsulfatase A	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
D(1A) dopamine receptor	1	0	0	1
chromobox protein homolog 1	8	0	0	8
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
geminin	13	0	0	13
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Rap guanine nucleotide exchange factor 3	6	0	0	6
Plasminogen	0	4	2	6
Proton-coupled amino acid transporter 1	0	5	0	6
Lysyl oxidase homolog 2	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	8	0	0	8
phosphopantetheinyl transferase	6	0	0	6
NFKB1 protein, partial	1	0	0	1
GLS protein	4	0	0	4
thyroid stimulating hormone receptor	5	0	0	5
alpha-galactosidase	1	0	0	1
cytochrome P450 2C19 precursor	5	0	0	5
flap endonuclease 1	5	0	0	5
DNA polymerase iota isoform a (long)	8	0	0	8
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	4	0	0	4
Cytochrome P450 3A4	0	0	0	1
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	4	0	0	4
Carbonic anhydrase 1	0	5	0	9
Carbonic anhydrase 2	0	5	0	9
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	4
Amino acid transporter	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
hypothetical protein, conserved	1	0	0	1
estrogen-related nuclear receptor alpha	14	0	0	14
cytochrome P450 2D6	4	0	0	4
glucocerebrosidase	1	0	0	1
Rac1 protein	0	0	1	1
IDH1	7	0	0	7
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase kappa isoform 1	6	0	0	6
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Bile salt export pump	0	12	0	12
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	2	1	0	3
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	2	1	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	2	0	4
Adenosine receptor A2a	0	2	0	4
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	0	5
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	6	0	6
Sigma non-opioid intracellular receptor 1	0	4	1	5
Sigma non-opioid intracellular receptor 1	0	0	1	1
acetylcholinesterase	5	0	0	5
SMAD family member 2	2	0	0	2
Fumarate hydratase	1	0	0	1
SMAD family member 3	2	0	0	2
TDP1 protein	12	0	0	12
Microtubule-associated protein tau	4	0	0	4
thioredoxin glutathione reductase	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	12	0	0	12
G	6	0	0	6
polyprotein	1	0	0	1
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	7	0	0	7
aryl hydrocarbon receptor	8	0	0	8
thyroid stimulating hormone receptor	4	0	0	4
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
thyroid hormone receptor beta isoform 2	8	0	0	8
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	1	0	0	1
cytochrome P450 3A4 isoform 1	4	0	0	4
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	0	0	4
Bile salt export pump	0	2	0	2
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Cellular tumor antigen p53	10	0	0	10
Gamma-aminobutyric acid receptor subunit beta-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit delta	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-2	4	0	0	4
GABA theta subunit	4	0	0	4
Inositol hexakisphosphate kinase 1	6	0	0	6
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit epsilon	4	0	0	4
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
pregnane X receptor	2	0	0	2
progesterone receptor	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
Carbonic anhydrase 4	0	3	0	6
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase 15	0	1	0	4
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
General amino-acid permease GAP1	0	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2B6	0	3	0	3
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Cytochrome P450 2C19	0	3	0	3
Rap guanine nucleotide exchange factor 4	2	0	0	2
P2Y purinoceptor 12	0	1	0	1
Vasopressin V2 receptor	0	2	2	4
Oxytocin receptor	0	2	3	5
Vasopressin V1a receptor	0	3	2	5
Vasopressin V1b receptor	0	2	2	4
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	2	1	3
Luciferase	7	0	0	7
USP1 protein, partial	4	0	0	4
estrogen receptor 2 (ER beta)	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
NAD	0	1	0	1
Cholinesterase	0	1	0	1
Urease	0	1	0	1
Cytochrome P450 2C9	0	5	0	5
NAD	0	1	0	2
Mitogen-activated protein kinase 1	0	1	0	1
Histamine H2 receptor	3	0	0	3
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Integrase	0	2	0	2
G-protein coupled receptor 35	0	2	2	4
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	1	0	3
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Amyloid-beta precursor protein	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Chain A, Beta-lactamase	4	0	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, Casein kinase II subunit alpha	0	1	0	1
endonuclease IV	1	0	0	1
Mcl-1	0	1	0	1
acetyl-CoA acetyltransferase/HMG-CoA reductase	0	1	0	1
apical membrane antigen 1, AMA1	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
unnamed protein product	0	1	0	1
heat shock 70kDa protein 1A	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
fructose-bisphosphate aldolase A	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
mitogen-activated protein kinase 1	3	0	0	3
dual specificity protein phosphatase 3	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
snurportin-1	1	0	0	1
mothers against decapentaplegic homolog 3 isoform 1	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
DNA polymerase eta isoform 1	3	0	0	3
heat shock cognate 71 kDa protein isoform 1	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
dual specificity protein phosphatase 6	0	1	0	1
heat shock cognate 71 kDa protein isoform 2	0	1	0	1
Serine/threonine-protein kinase PLK4	0	1	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	0	1
Aurora kinase A	0	1	0	1
Acetylcholinesterase	0	2	0	3
Carbonic anhydrase 12	0	1	0	4
NUAK family SNF1-like kinase 1	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Renin	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	1	0	1
Nucleophosmin	0	1	0	1
Carbonic anhydrase 3	0	1	0	4
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	0	1
Insulin-like growth factor 1 receptor	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Hepatocyte growth factor receptor	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Cytochrome P450 2D6	0	4	0	4
Glutathione S-transferase Mu 1	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Cyclin-dependent kinase 4	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Macrophage migration inhibitory factor	0	2	0	2
Serine/threonine-protein kinase B-raf	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Casein kinase II subunit alpha'	0	1	0	1
Cyclin-A2	0	1	0	1
Amine oxidase [flavin-containing] A	0	0	1	1
5'-nucleotidase	0	1	0	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	0	1
Carbonic anhydrase 6	0	2	0	5
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-dependent kinase 2	0	1	0	1
Cruzipain	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	5
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Mitogen-activated protein kinase kinase kinase 8	0	1	0	1
Carbonic anhydrase 7	0	2	0	5
Glycogen synthase kinase-3 beta	0	1	0	1
Squalene monooxygenase	0	1	0	1
Serine/threonine-protein kinase PLK1	0	1	0	1
Ephrin type-B receptor 4	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
Beta-secretase 1	0	1	0	1
Spike glycoprotein	4	0	0	4
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	2	0	2
Cyclin-A1	0	1	0	1
Lactoperoxidase	0	0	0	1
Cholinesterase	0	1	0	2
DNA primase	0	1	0	1
Angiopoietin-1 receptor	0	1	0	1
Focal adhesion kinase 1	0	1	0	1
Tyrosine-protein kinase Lyn	0	1	0	1
Polypeptide N-acetylgalactosaminyltransferase 2	0	1	1	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
ELAV-like protein 3	0	1	0	1
Carbonic anhydrase 9	0	2	0	5
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
5'-nucleotidase	0	1	0	1
Tyrosine-protein kinase Fgr	0	1	0	1
Thioredoxin reductase 3	0	1	0	1
Glutathione S-transferase	0	1	0	1
Carbonic anhydrase 13	0	1	0	2
Aurora kinase B	0	1	0	1
Translin-associated protein X	0	1	0	1
Carbonic anhydrase 13	0	2	0	4
Thioredoxin reductase 2, mitochondrial	0	1	0	1
Carbonic anhydrase 14	0	1	0	4
ALK tyrosine kinase receptor	0	1	0	1
DNA polymerase iota	0	1	0	1
DNA polymerase eta	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	5
Cysteine protease ATG4B	0	1	0	1
phosphoglycerate kinase	1	0	0	1
M17 leucyl aminopeptidase	0	1	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
glp-1 receptor, partial	3	0	0	3
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Smad3	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Estrogen receptor	0	4	0	4
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	4	0	4
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	4	0	4
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
C-8 sterol isomerase	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Alpha-synuclein	1	1	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Coagulation factor X	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	6
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	6
Glutamate receptor ionotropic, NMDA 2B	0	2	1	6
Glutamate receptor ionotropic, NMDA 2C	0	2	1	6
Large neutral amino acids transporter small subunit 1	0	7	0	8
Glutamate receptor ionotropic, NMDA 2D	0	2	1	6
Glutamate receptor ionotropic, NMDA 3B	0	2	1	6
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	6
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	4
histone deacetylase 9 isoform 3	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
PPM1D protein	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Plasma kallikrein	0	0	0	3
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Carbonic anhydrase	0	0	0	3
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
GALC protein	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	2	0	2
Estrogen receptor beta	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Urokinase-type plasminogen activator	0	1	0	1
acid sphingomyelinase	1	0	0	1
67.9K protein	1	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(10)

Research Excerpts

Overview

Research

Studies (168)

Protein Targets (623)

Deficiency, Factor 11

Synonyms(10)

Research Excerpts

Overview

Research

Studies (168)

Drugs Studied (87)

Protein Targets (623)