Page last updated: 2024-09-28

Coagulation Factor 12 Deficiency

An absence or reduced level of blood coagulation factor XII. It normally occurs in the absence of patient or family history of hemorrhagic disorders and is marked by prolonged clotting time.

Synonyms(9)

Synonym
Deficiency, Factor XII
Hageman Trait
Deficiency, Factor 12
Factor 12 Deficiency
Factor XII Deficiency
Factor Twelve Deficiency
Hageman Factor Deficiency
Deficiency, Factor Twelve
Coagulation Factor 12 Deficiency

Research Excerpts

Research

Studies (106)

TimeframeStudies, This Condition (%)All Conditions %
pre-199060 (56.60)23.3326
1990's24 (22.64)12.5806
2000's13 (12.26)18.1394
2010's7 (6.60)28.8240
2020's2 (1.89)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetone0low10
ammonium hydroxide0low10
aspirin0low20
benzamidine0low10
valproic acid0low10
furosemide0low10
indomethacin0low10
ethylmaleimide0low10
corticosterone0low10
prednisone0low10
alanine0low10
serine0low10
adenosine diphosphate0low20
methylprednisolone0low10
pyrrolidonecarboxylic acid0low10
acetylcysteine0low10
silver0low10
hexadimethrine bromide0low10
trolamine salicylate0low20
captopril0low20
fibrinogen0low100
prolyl-phenylalanyl-arginine-4-nitroanilide0low20
s 23660low10
proline0low10
angiotensin ii0low10
fibrin0low70
bradykinin0low40
arginine vasopressin0low10
benzoyl-pro-phe-arg-p-nitroanilide0low20
vitamin k semiquinone radical0low10
ellagic acid0low30
brefeldin a0low10
deamino arginine vasopressin0low50
cytochalasin b0low10
silicon0low10
saralasin0low10
lactacystin0low10
benzoyl-ile-glu-gly-arg-p-nitroanilide0low20
ristocetin0low10
fibrinopeptide a0low30
piperidines0low10
acenocoumarol0low20
warfarin0low30
phenprocoumon0low20
kaolinite0low120
hirudin0low10
hyaluronoglucosaminidase0low10
amyloid beta-peptides0low10
thromboplastin0low150

Protein Targets (639)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Luciferase5005
RAR-related orphan receptor gamma9009
retinoid X nuclear receptor alpha6006
G4004
peroxisome proliferator activated receptor gamma4004
euchromatic histone-lysine N-methyltransferase 2130013
thyroid stimulating hormone receptor2002
chromobox protein homolog 19009
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
geminin120012
muscleblind-like protein 1 isoform 14004
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 4004
Guanine nucleotide-binding protein G3003
Inositol hexakisphosphate kinase 14004
cytochrome P450 2C9, partial4004
TDP1 protein9009
glucocorticoid receptor [Homo sapiens]110011
estrogen-related nuclear receptor alpha100010
thyroid hormone receptor beta isoform 29009
lamin isoform A-delta10100010
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
acetylcholinesterase2002
dopamine D1 receptor1001
15-lipoxygenase, partial3003
pregnane X receptor4004
phosphopantetheinyl transferase4004
USP1 protein, partial4004
NFKB1 protein, partial3003
Microtubule-associated protein tau6006
Thrombopoietin5005
AR protein9009
regulator of G-protein signaling 44004
retinoic acid nuclear receptor alpha variant 18008
farnesoid X nuclear receptor5005
estrogen nuclear receptor alpha110011
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
arylsulfatase A2002
Bloom syndrome protein isoform 15005
D(1A) dopamine receptor1001
thyroid hormone receptor beta isoform a7007
heat shock protein beta-13003
flap endonuclease 13003
peripheral myelin protein 225005
survival motor neuron protein isoform d4004
muscarinic acetylcholine receptor M14004
Histone deacetylase 30303
Solute carrier family 22 member 60404
Histone deacetylase 40303
Histone deacetylase 10303
Histone deacetylase 70303
Histone deacetylase 20303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Ataxin-25005
Histone deacetylase 80303
Histone deacetylase 60303
Histone deacetylase 90303
Histone deacetylase 50303
ATP-dependent phosphofructokinase6006
Chain A, Heat Shock Protein 900011
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, Myosin Ie Heavy Chain0011
Chain A, Preprotein translocase secA0011
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Phosphoribosylformylglycinamidine synthase0101
Chain A, nucleoside diphosphate kinase A0011
Chain B, nucleoside diphosphate kinase A0011
Chain D, DNA polymerase III subunit gamma0011
Chain D, DNA polymerase III subunit gamma0011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A, Kinesin-like protein KIF110101
HPr kinase/phosphorylase0011
Mitogen-activated protein kinase kinase kinase 70011
ATP-dependent molecular chaperone HSP820001
Heat shock protein HSP 90-alpha0113
Heat shock protein HSP 90-beta0113
2-dehydropantoate 2-reductase0112
Heat shock 70 kDa protein 1A 0112
Endoplasmic reticulum chaperone BiP0011
Heat shock cognate 71 kDa protein0011
Pyruvate kinase PKM 0001
Pyruvate kinase PKLR 0001
Endoplasmin0001
Heat shock cognate 71 kDa protein0011
5'-nucleotidase0101
Mu-type opioid receptor0011
Delta-type opioid receptor0011
Kappa-type opioid receptor0011
Endoplasmin0112
P2Y purinoceptor 20011
Phosphatidylinositol 4-kinase alpha0202
P2X purinoceptor 10011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
P2X purinoceptor 10011
P2X purinoceptor 40011
P2X purinoceptor 50011
P2X purinoceptor 60011
P2X purinoceptor 30011
Inositol monophosphatase 12002
Heat shock protein 75 kDa, mitochondrial0101
P2Y purinoceptor 60011
Phosphatidylinositol 4-kinase type 2-beta0202
P2Y purinoceptor 110011
Phosphatidylinositol 4-kinase type 2-alpha0202
P2Y purinoceptor 120112
Sensor protein kinase WalK0101
Phosphatidylinositol 4-kinase beta0202
P2X purinoceptor 20011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Carbonic anhydrase 10507
Carbonic anhydrase 20507
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0202
Proton-coupled amino acid transporter 10303
Adenosine deaminase0001
Carbonic anhydrase 40001
glucocerebrosidase3003
DNA polymerase kappa isoform 15005
histone acetyltransferase KAT2A isoform 14004
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0336
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0314
Type-1 angiotensin II receptor0437
Type-2 angiotensin II receptor0213
Type-2 angiotensin II receptor0404
vitamin D3 receptor isoform VDRA6006
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40707
Bile salt export pump010010
Translocator protein0011
Vasopressin V2 receptor0326
Oxytocin receptor0123
Vasopressin V1a receptor0022
Vasopressin V1a receptor0224
Vasopressin V1b receptor0224
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0203
Oxytocin receptor0101
Vasopressin V2 receptor 0224
Canalicular multispecific organic anion transporter 10707
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 83003
thioredoxin reductase7007
GLS protein3003
aldehyde dehydrogenase 1 family, member A16006
thyroid stimulating hormone receptor2002
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 45005
EWS/FLI fusion protein6006
cytochrome P450 2D61001
peroxisome proliferator-activated receptor delta3003
Rac1 protein0011
IDH16006
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase iota isoform a (long)5005
lethal factor (plasmid)4004
Prostaglandin-H2 D-isomerase0202
Prostaglandin G/H synthase 1 0203
Prostaglandin G/H synthase 2 0203
Epidermal growth factor receptor0303
Fatty acid-binding protein, liver0101
Integrin beta-30101
Myeloperoxidase0101
Prostaglandin G/H synthase 10304
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10404
Adenosine receptor A10303
Adenosine receptor A2a0303
Substance-P receptor0202
Prostaglandin G/H synthase 20516
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma6006
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-11102
Prostaglandin G/H synthase 20303
Rho-associated protein kinase 20202
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10112
Sigma non-opioid intracellular receptor 10011
Chain A, TRYPSIN0101
Chain H, Thrombin heavy chain0101
Chain H, Thrombin heavy chain0101
Chain A, PROTEIN (TRYPSIN)0101
Chain A, PROTEIN (TRYPSIN)0101
Chain A, PROTEIN (TRYPSIN)0101
Chain A, PROTEIN (TRYPSIN)0101
Chain B, PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)0101
Chain B, PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)0101
Chain B, PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)0101
Chain A, PROTEIN (TRYPSIN)0101
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, TRYPSIN IVA0101
Chain A, trypsin II, anionic0101
Chain A, Trypsin II, anionic0101
Chain A, Trypsin II, anionic0101
Chain T, Trypsin II, anionic0101
Chain A, trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain T, Trypsin0101
Chain A, PROTEIN (TRYPSIN)0101
pyruvate kinase PKM isoform b1001
Prothrombin0213
Prothrombin 0101
Coagulation factor X0101
Coagulation factor X0101
Urokinase-type plasminogen activator0202
Tissue-type plasminogen activator0101
Cationic trypsin0101
Acrosin0101
Coagulation factor VII0101
Ornithine decarboxylase1001
Tissue factor0202
Aldehyde oxidase0002
Suppressor of tumorigenicity 14 protein0101
Angiotensin-converting enzyme 0416
B2 bradykinin receptor0101
B2 bradykinin receptor0215
B1 bradykinin receptor0101
Olfactory receptor 51E20011
PAX80001
ATAD5 protein, partial1001
thioredoxin glutathione reductase6006
Smad33003
67.9K protein3003
NPC intracellular cholesterol transporter 1 precursor2002
major prion protein preproprotein Prp precursor0101
nuclear receptor subfamily 0 group B member 10101
nuclear factor erythroid 2-related factor 2 isoform 25005
ras-related protein Rab-9A3003
steroidogenic factor 10101
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Chain A, angiotensin converting enzyme0101
Chain A, angiotensin converting enzyme0101
Metallo-beta-lactamase type 20112
peripheral myelin protein 22 isoform 14004
M-phase phosphoprotein 83003
transient receptor potential cation channel subfamily V member 11001
Renin0202
Neprilysin0101
Neprilysin0101
Leukotriene A-4 hydrolase0213
EEF1AKMT4-ECE2 readthrough transcript protein0101
Angiotensin-converting enzyme0203
Leukotriene A-4 hydrolase0101
Thymidine phosphorylase0011
Endothelin-converting enzyme 10101
Succinyl-diaminopimelate desuccinylase0202
Angiotensin-converting enzyme0202
Solute carrier family 15 member 10101
Beta-lactamase TEM0101
Mu-type opioid receptor0011
TAR DNA-binding protein 431001
Beta-lactamase 0203
Beta-lactamase 0202
Angiotensin-converting enzyme 2 0101
Beta-lactamase class B VIM-2 0112
GALC protein2002
GLI family zinc finger 35005
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
nuclear receptor subfamily 1, group I, member 33003
pregnane X nuclear receptor5005
bromodomain adjacent to zinc finger domain 2B5005
caspase-31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
activating transcription factor 61001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x2002
potassium voltage-gated channel subfamily H member 2 isoform d2002
FAD-linked sulfhydryl oxidase ALR0001
nuclear factor erythroid 2-related factor 2 isoform 17007
Carbonic anhydrase 120304
Cellular tumor antigen p535005
Cytochrome P450 2D60404
Spike glycoprotein5005
Carbonic anhydrase 90304
ATPase family AAA domain-containing protein 54004
Solute carrier organic anion transporter family member 1B30404
progesterone receptor5005
nonstructural protein 12002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
mitogen-activated protein kinase 13003
serine/threonine-protein kinase mTOR isoform 12002
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0202
Solute carrier family 22 member 30101
Solute carrier family 22 member 30101
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0011
Androgen receptor0303
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
C-8 sterol isomerase0101
Solute carrier organic anion transporter family member 1A10101
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Solute carrier family 22 member 10202
GABA theta subunit1001
Gamma-aminobutyric acid receptor subunit epsilon1001
Solute carrier family 22 member 20202
glp-1 receptor, partial1001
PINK11001
Parkin2002
neutrophil cytosol factor 10101
Solute carrier family 2, facilitated glucose transporter member 10101
Solute carrier family 2, facilitated glucose transporter member 30101
Solute carrier family 2, facilitated glucose transporter member 40101
Chain A, Beta-lactamase3003
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, Casein kinase II subunit alpha0101
endonuclease IV1001
Mcl-10101
acetyl-CoA acetyltransferase/HMG-CoA reductase0101
apical membrane antigen 1, AMA11001
unnamed protein product0101
heat shock 70kDa protein 1A0101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
Aldehyde oxidase 10101
serine-protein kinase ATM isoform a1001
lysosomal alpha-glucosidase preproprotein1001
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor2002
runt-related transcription factor 1 isoform AML1b1001
fructose-bisphosphate aldolase A1001
core-binding factor subunit beta isoform 21001
glyceraldehyde-3-phosphate dehydrogenase isoform 11001
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
dual specificity protein phosphatase 30101
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase PLK11001
snurportin-11001
mothers against decapentaplegic homolog 3 isoform 10101
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
heat shock cognate 71 kDa protein isoform 10101
eukaryotic translation initiation factor 4E isoform 10101
nuclear receptor ROR-gamma isoform 14004
Vif0101
Tat0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
dual specificity protein phosphatase 60101
heat shock cognate 71 kDa protein isoform 20101
Serine/threonine-protein kinase PLK40101
Inhibitor of nuclear factor kappa-B kinase subunit beta0101
Aurora kinase A0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Acetylcholinesterase0203
NUAK family SNF1-like kinase 10101
Rap guanine nucleotide exchange factor 32002
Glutathione reductase, mitochondrial0101
cAMP-dependent protein kinase catalytic subunit alpha0101
Receptor tyrosine-protein kinase erbB-20101
Amyloid-beta precursor protein0101
Insulin receptor0101
Nucleophosmin0101
Carbonic anhydrase 30202
Proto-oncogene tyrosine-protein kinase receptor Ret0101
Insulin-like growth factor 1 receptor0101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Hepatocyte growth factor receptor0101
Muscarinic acetylcholine receptor M50101
Glutathione S-transferase P0101
Platelet-derived growth factor receptor beta0101
Glutathione S-transferase Mu 10101
Muscarinic acetylcholine receptor M20101
Cyclin-dependent kinase 40101
Proto-oncogene tyrosine-protein kinase Src0101
Macrophage migration inhibitory factor0202
Serine/threonine-protein kinase B-raf0101
Aldo-keto reductase family 1 member B10202
cAMP-dependent protein kinase catalytic subunit alpha0101
Casein kinase II subunit alpha 0101
Glutamate receptor 11001
Glutamate receptor 22002
Glutamate receptor 31001
Glutamate receptor 41001
Casein kinase II subunit alpha'0101
Cyclin-A20101
Amine oxidase [flavin-containing] A0011
5'-nucleotidase0101
cAMP-dependent protein kinase catalytic subunit gamma0101
cAMP-dependent protein kinase catalytic subunit beta0101
Carbonic anhydrase 40203
Carbonic anhydrase 60203
G1/S-specific cyclin-D10101
Cyclin-dependent kinase 20101
Cruzipain0101
RAC-alpha serine/threonine-protein kinase0101
Bifunctional epoxide hydrolase 20202
Carbonic anhydrase 5A, mitochondrial0203
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
Receptor-type tyrosine-protein kinase FLT30101
Mitogen-activated protein kinase kinase kinase 80101
Carbonic anhydrase 70203
Histamine H2 receptor2002
Glycogen synthase kinase-3 beta0101
Squalene monooxygenase 0101
Serine/threonine-protein kinase PLK10101
Ephrin type-B receptor 40101
Ectonucleoside triphosphate diphosphohydrolase 10101
Beta-secretase 10101
Casein kinase II subunit beta0101
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0202
Cyclin-A10101
Lactoperoxidase0001
Cholinesterase0102
DNA primase0101
Angiopoietin-1 receptor0101
Focal adhesion kinase 10101
Tyrosine-protein kinase Lyn 0101
Polypeptide N-acetylgalactosaminyltransferase 20112
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
ELAV-like protein 30101
Thioredoxin reductase 1, cytoplasmic0101
Solute carrier family 22 member 60202
5'-nucleotidase0101
Tyrosine-protein kinase Fgr0101
Integrase 0101
Thioredoxin reductase 30101
Glutathione S-transferase0101
Carbonic anhydrase 130101
Rap guanine nucleotide exchange factor 41001
Aurora kinase B0101
Translin-associated protein X0101
Carbonic anhydrase 130203
G-protein coupled receptor 350224
Thioredoxin reductase 2, mitochondrial0101
Carbonic anhydrase 140203
ALK tyrosine kinase receptor0101
DNA polymerase iota0101
DNA polymerase eta0101
Carbonic anhydrase 5B, mitochondrial0203
Cysteine protease ATG4B0101
phosphoglycerate kinase1001
M17 leucyl aminopeptidase0101
likely tRNA 2'-phosphotransferase0101
neuropeptide S receptor isoform A2002
Ghrelin O-acyltransferase0101
Monoglyceride lipase0101
14 kDa phosphohistidine phosphatase0101
estrogen receptor 2 (ER beta)3003
aryl hydrocarbon receptor2002
thyrotropin-releasing hormone receptor1001
Bile salt export pump0202
Albumin0224
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0202
Serum paraoxonase/arylesterase 10202
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20101
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Multidrug and toxin extrusion protein 10202
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Cruzipain1001
hypoxia-inducible factor 1 alpha subunit2002
SMAD family member 21001
SMAD family member 31001
cytochrome P450 2D6 isoform 11001
Prostaglandin E synthase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Voltage-dependent calcium channel gamma-2 subunit1001
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Phospholipase A2, major isoenzyme0101
Procathepsin L0101
ATP-dependent translocase ABCB10101
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0011
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Nitric oxide synthase, inducible0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Prostaglandin G/H synthase 2 0101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Potassium voltage-gated channel subfamily H member 20101
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin G/H synthase 1 0101
Solute carrier family 22 member 80101
Dehydrogenase/reductase SDR family member 90101
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
Proteasome subunit beta type-110101
Proteasome subunit alpha type-70101
Proteasome subunit beta type-10101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50101
Proteasome subunit beta type-100101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20101
Proteasome subunit alpha type-60101
Splicing factor 3B subunit 30101
Proteasome subunit alpha-type 80101
Proteasome subunit beta type-70101
PPM1D protein2002
nuclear receptor subfamily 1, group I, member 21001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor0415
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Nuclear receptor subfamily 1 group I member 20011
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Protease 0303
Glutamate 5-kinase0001
Neutral amino acid transporter A0202
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
Pyruvate kinase PKM0011
Chain A, PLASMINOGEN0011
Chain A, PLASMINOGEN0011
Plasminogen0213
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Aldo-keto reductase family 1 member B10101
Cytochrome P450 2A60101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Chain A, Ferritin light chain1001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]