cysteine biosynthetic process from serine

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. [GOC:go_curators]

The biosynthesis of cysteine from serine is a complex metabolic pathway that involves multiple enzymes and cofactors. The process begins with the conversion of serine to O-acetylserine by the enzyme serine acetyltransferase. This reaction requires acetyl-CoA as a cofactor. O-acetylserine is then converted to cysteine by the enzyme cysteine synthase. This reaction requires sulfide as a cofactor. Cysteine synthase catalyzes the reaction of O-acetylserine with sulfide to form cysteine and acetate. The sulfide used in this reaction is derived from the reduction of sulfate by the enzyme sulfite reductase. The reduction of sulfate to sulfide is a complex process that involves multiple steps. The first step is the reduction of sulfate to sulfite by the enzyme ATP sulfurylase. This reaction requires ATP and inorganic phosphate as cofactors. Sulfite is then reduced to sulfide by the enzyme sulfite reductase. This reaction requires NADPH as a cofactor. The cysteine biosynthetic pathway is essential for the synthesis of proteins and other biomolecules that contain cysteine residues. Cysteine is also a precursor for the synthesis of glutathione, an important antioxidant that protects cells from oxidative damage.'
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Proteins (1)

Compounds (8)