nitric oxide binding

Definition

Target type: molecularfunction

Binding to nitric oxide (NO). [GOC:ecd]

Nitric oxide (NO) binding is a molecular function that describes the ability of a molecule to interact with nitric oxide. NO is a small, highly reactive molecule that plays a crucial role in a variety of physiological processes, including vasodilation, neurotransmission, and immune regulation. NO binding can occur through various mechanisms, including coordination with transition metal ions, such as iron in heme groups, or through direct interaction with specific amino acid residues. The binding of NO to a protein can induce conformational changes, alter its activity, or modulate its interactions with other molecules. For example, in the case of soluble guanylate cyclase (sGC), NO binding activates the enzyme, leading to the production of cyclic GMP (cGMP), a signaling molecule that mediates vasodilation. NO binding can also regulate the activity of other proteins, such as transcription factors, enzymes involved in metabolism, and ion channels. The specificity of NO binding is determined by the structure and chemical environment of the binding site. The ability of proteins to bind NO is essential for the regulation of a wide range of physiological processes. Disruptions in NO binding can contribute to the development of various diseases, including cardiovascular disease, neurodegenerative disorders, and cancer.'
"

Proteins (2)

Compounds (18)