Compounds > dykellic acid
Page last updated: 2024-12-11

dykellic acid

Description

dykellic acid: an apoptosis inhibitor isolated from Westerdykella multispora; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6397984
CHEMBL ID449742
MeSH IDM0360000

Synonyms (5)

Synonym
3-[5-methylidene-2-oxo-6-[(1e,3e)-penta-1,3-dienyl]pyran-3-yl]propanoic acid
CHEMBL449742
dykellic acid
3-(5-methylene-2-oxo-6-((1e,3e)-penta-1,3-dien-1-yl)-5,6-dihydro-2h-pyran-3-yl)propanoic acid
1097679-78-1

Research Excerpts

Overview

Dykellic acid is a novel microbial metabolite isolated from the broth of Westerdykella multispora.

ExcerptReferenceRelevance
"Dykellic acid is a novel microbial metabolite isolated from the broth of Westerdykella multispora F50733. "( Dykellic acid inhibits drug-induced caspase-3-like protease activation.
Kho, YH; Kim, HM; Kim, SU; Lee, HJ; Lee, SH; Youk, ES, 2003)		3.2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID412555Inhibition of recombinant caspase 3 activity expressed in Escherichia coli BL21 (DE3) assessed as p-nitroaniline release using Ac-DEVD-pNA substrate up to 100 uM2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
AID412559Cytoprotective activity against 20 uM rotenone-induced intracellular ROS production in human U937 cells at 100 uM pretreated for 5 hrs by 2,7-dichlorodihydrofluorescein dye reduction assay2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
AID412556Inhibition of recombinant caspase 6 activity expressed in Escherichia coli BL21 (DE3) assessed as p-nitroaniline release using Ac-VEID-pNA substrate up to 100 uM2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
AID412558Inhibition of recombinant caspase 8 activity expressed in Escherichia coli BL21 (DE3) assessed as p-nitroaniline release using Ac-IETD-pNA substrate up to 100 uM2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
AID412554Antiapoptotic activity in human U937 cells assessed as reduction of 1.5 uM etoposide-induced caspase-3/7 like activity at 100 nM pretreated for 5 hrs measured after 24 hrs relative to control2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
AID412551Cytoprotective activity against 50 uM N-methyl-N'-nitro-N-nitrosoguanidine-induced cell death in human U937 cells pretreated for 5 hrs measured after 24 hrs by cell flow cytometry using propidium iodide staining relative to control2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
AID412552Cytoprotective activity against 50 uM H2O2-induced cell death in human U937 cells pretreated for 5 hrs measured after 24 hrs by cell flow cytometry using propidium iodide staining relative to control2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
AID412557Inhibition of recombinant caspase 7 activity expressed in Escherichia coli BL21 (DE3) assessed as p-nitroaniline release using Ac-DEVD-pNA substrate up to 100 uM2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
AID412549Cytoprotective activity against 5 uM rotenone-induced cell death in human U937 cells pretreated for 5 hrs measured after 24 hrs by cell flow cytometry using propidium iodide staining relative to control2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
AID412765Cytoprotective activity against 20 uM rotenone-induced intracellular ROS production in human U937 cells at 100 uM pretreated for 5 hrs by dihydroethidium dye reduction assay2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
AID412553Antiapoptotic activity in human U937 cells assessed as reduction of 1.5 uM etoposide-induced caspase-3/7 like activity pretreated for 5 hrs measured after 24 hrs relative to control2009Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
Total synthesis and cytoprotective properties of dykellic acid.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.99

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.99 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.94 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.99)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thioctic acid
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.		2.0110dithiolanes;
heterocyclic fatty acid;
thia fatty acid		fundamental metabolite;
geroprotector
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		2.0510alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0110delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		2.0110acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
alkenes
[no description available]		2.0510
prolinedithiocarbamate
prolinedithiocarbamate: do not confuse with pyrrolidine dithiocarbamate which is also abbreviated PDTC		2.0110
proline
Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.		2.0110amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
organophosphonates
hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.		2.0510divalent inorganic anion;
phosphite ion
ConditionIndicatedRelationship StrengthStudiesTrials
Invasiveness, Neoplasm
[description not available]		02.4220
Angiogenesis, Pathologic
[description not available]		02.0310
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