dipfluzine has been researched along with cinnarizine in 23 studies
| Studies (dipfluzine) | Trials (dipfluzine) | Recent Studies (post-2010) (dipfluzine) | Studies (cinnarizine) | Trials (cinnarizine) | Recent Studies (post-2010) (cinnarizine) |
|---|---|---|---|---|---|
| 23 | 0 | 8 | 855 | 148 | 190 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 9 (39.13) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, SX; Jin, S; Li, YS; Wang, YL | 1 |
| He, RR; Wang, YL | 4 |
| Wang, YL; Yang, XP; Zhu, YH | 1 |
| He, RR; Li, DP; Wang, YL; Xue, BJ; Zhang, YJ | 1 |
| Bai, J; Wang, Y | 1 |
| Wang, C; Want, YL; Zhang, YJ | 1 |
| Guo, Y; Jia, QZ; Wang, YL; Zhang, HL; Zhang, YJ | 1 |
| Du, YM; Liu, HC; Wang, YL | 1 |
| Lü, P; Wang, YL; Zhang, GH | 1 |
| Chen, ZY; Liu, LL; Liu, S; Wang, C; Wang, YL; Xu, YF; Zhang, YJ | 1 |
| Dong, LF; Jia, QZ; Li, JX; Wang, YL; Yin, JX; Zhang, YJ | 1 |
| Dong, L; Hu, H; Pei, T; Wang, Y; Xu, Y | 1 |
| Wang, J; Yang, CQ; Zhang, ZW | 1 |
| Du, Y; Guo, W; Kong, D; Shi, X; Wang, W; Wang, Y | 1 |
| An, Z; Wang, J; Xu, X; Yang, C | 1 |
| Lin, Y; Wang, J; Yang, C; Yang, H | 1 |
| Guo, W; Li, J; Shi, X; Wang, W; Xiong, C | 1 |
| Guo, W; Li, J; Shi, X; Wang, W; Zhang, W | 1 |
| Guo, W; He, C; Li, S; Wang, H; Wang, T; Wang, X; Wang, Y | 1 |
| Guo, W; Li, S; Liu, L; Wang, H; Wang, J; Wang, Y | 1 |
23 other study(ies) available for dipfluzine and cinnarizine
| Article | Year |
|---|---|
Acute toxicity of dipfluzine and its effects on isolated vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Basilar Artery; Cinnarizine; Coronary Vessels; Female; In Vitro Techniques; Lethal Dose 50; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Swine | 1990 |
Effect of dipfluzine on platelet aggregation and thrombus formation.
Topics: Animals; Carotid Artery Thrombosis; Cinnarizine; Dose-Response Relationship, Drug; Female; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Wistar; Thrombosis | 1994 |
Protective effect of dipfluzine on experimental brain edema in rats.
Topics: Animals; Brain Edema; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Cinnarizine; Female; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar | 1994 |
Selective vasodilatory effect of dipfluzine on vertebral artery in anesthetized dogs.
Topics: Animals; Cinnarizine; Coronary Vessels; Dogs; Female; Femoral Artery; Hemodynamics; Male; Vascular Resistance; Vasodilator Agents; Vertebral Artery | 1993 |
Effects of dipfluzine on cortical somatosensory evoked potentials and amino acid contents in ischemic rat brain.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cinnarizine; Evoked Potentials, Somatosensory; Excitatory Amino Acids; Female; Rats; Rats, Wistar | 1996 |
Antagonistic effects of dipfluzine, flunarizine, and cinnarizine on 5-hydroxytryptamine-evoked contraction in pig basilar artery.
Topics: Animals; Basilar Artery; Calcium Channel Blockers; Cinnarizine; Flunarizine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Serotonin Antagonists | 1996 |
Effect of dipfluzine on L-type calcium current in guinea pig ventricular myocytes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Separation; Cinnarizine; Female; Guinea Pigs; Heart Ventricles; Male; Membrane Potentials; Myocytes, Cardiac; Patch-Clamp Techniques | 2001 |
[Effect of dipfluzine on acute ischemic brain edema in gerbils].
Topics: Acute Disease; Animals; Brain; Brain Edema; Brain Ischemia; Cinnarizine; Dose-Response Relationship, Drug; Female; Gerbillinae; Hippocampus; Male; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase; Water | 2002 |
Effects of dipfluzine on delayed afterdepolarizations and triggered activity induced by ouabain in guinea pig papillary muscles.
Topics: Animals; Calcium; Calcium Channel Blockers; Cinnarizine; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Male; Microelectrodes; Neuromuscular Depolarizing Agents; Ouabain; Papillary Muscles | 2002 |
Mechanism of anti-apoptotic action of dipfluzine on neuronal damage of the rat hippocampal CA1 region subjected to transient forebrain ischemia.
Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channel Blockers; Cinnarizine; Fas Ligand Protein; fas Receptor; Female; Hippocampus; Membrane Glycoproteins; Neurons; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Signal Transduction; Tumor Necrosis Factors | 2005 |
[Metabolic pathways of dipfluzine in rats].
Topics: Animals; Benzophenones; Chromatography, Liquid; Cinnarizine; Female; Gas Chromatography-Mass Spectrometry; Glucuronides; Male; Rats; Rats, Wistar | 2005 |
[Effects of dipfluzine on expressions of E-selectin, P-selectin, and ICAM-1 in brain ischemia-reperfusion rats].
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cinnarizine; Dose-Response Relationship, Drug; E-Selectin; Infarction, Middle Cerebral Artery; Intercellular Adhesion Molecule-1; Male; Neuroprotective Agents; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2005 |
Effect of dipfluzine on delayed afterdepolarizations and triggered activity induced by isoprenaline in human atrial fibers.
Topics: Action Potentials; Calcium Channel Blockers; Cinnarizine; Heart Atria; Humans; Isoproterenol; Microelectrodes; Purkinje Fibers | 2006 |
Repression of FasL expression by dipfluzine involves a mechanism of inhibition of NFATc transactivation.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Cinnarizine; Fas Ligand Protein; Female; Hippocampus; I-kappa B Proteins; Ischemic Attack, Transient; Neurons; NF-kappa B; NF-KappaB Inhibitor alpha; NFATC Transcription Factors; Promoter Regions, Genetic; Protein Binding; Random Allocation; Rats; Rats, Sprague-Dawley; Transcriptional Activation | 2008 |
Acute toxicity and toxicokinetics of dipfluzine hydrochloride, a novel calcium channel blocker.
Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cinnarizine; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Male; Molecular Structure; No-Observed-Adverse-Effect Level; Rats; Rats, Sprague-Dawley; Tissue Distribution; Toxicity Tests, Acute | 2009 |
[Synthesis and spectral characteristic of pharmaceutical dipfluzine hydrochloride-benzoic acid co-crystal].
Topics: Benzoic Acid; Cinnarizine; Crystallization; Hydrogen Bonding; Spectrum Analysis | 2011 |
Simultaneous determination of a novel diphenylpiperazine calcium channel blocker and its four metabolites in rat liver microsomes by liquid chromatography tandem mass spectrometry.
Topics: Animals; Calcium Channel Blockers; Chromatography, Liquid; Cinnarizine; Female; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sex Factors; Tandem Mass Spectrometry | 2012 |
Use of the co-grinding method to enhance the dissolution behavior of a poorly water-soluble drug: generation of solvent-free drug-polymer solid dispersions.
Topics: Calorimetry, Differential Scanning; Cinnarizine; Particle Size; Pharmaceutical Preparations; Poloxamer; Polymers; Povidone; Solubility; Solvents; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Water | 2012 |
Preparation, characterization, and evaluation of dipfluzine-benzoic acid co-crystals with improved physicochemical properties.
Topics: Animals; Benzoic Acid; Calcium Channel Blockers; Calorimetry, Differential Scanning; Cinnarizine; Crystallization; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Solubility; Spectroscopy, Fourier Transform Infrared; Water; X-Ray Diffraction | 2014 |
Pharmacokinetic evaluation of dipfluzine and its three metabolites in rat plasma using liquid chromatography-mass spectrometry.
Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cinnarizine; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2014 |
Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride.
Topics: Animals; Calcium Channel Blockers; Chromatography, Liquid; Cinnarizine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2014 |
Vasodilation activity of dipfluzine metabolites in isolated rat basilar arteries and their underlying mechanisms.
Topics: Animals; Basilar Artery; Cinnarizine; Endothelium, Vascular; In Vitro Techniques; Male; Potassium Channels; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2020 |
Interactions between dipfluzine-based complexes and cytochrome P450 enzymes: Information on salt, cocrystal, and salt cocrystal complexes.
Topics: Cinnarizine; Crystallization; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; Salts | 2020 |