Page last updated: 2024-09-04

dipfluzine and cinnarizine

dipfluzine has been researched along with cinnarizine in 23 studies

Compound Research Comparison

Studies
(dipfluzine)
Trials
(dipfluzine)
Recent Studies (post-2010)
(dipfluzine)
Studies
(cinnarizine)
Trials
(cinnarizine)
Recent Studies (post-2010) (cinnarizine)
2308855148190

Protein Interaction Comparison

ProteinTaxonomydipfluzine (IC50)cinnarizine (IC50)
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.832
Muscarinic acetylcholine receptor M4Homo sapiens (human)3.66
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.759
Alpha-2A adrenergic receptorHomo sapiens (human)0.444
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.513
D(2) dopamine receptorHomo sapiens (human)0.776
Alpha-2B adrenergic receptorHomo sapiens (human)2.242
Alpha-2C adrenergic receptorHomo sapiens (human)0.652
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.083
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.762
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.832
Alpha-1D adrenergic receptorHomo sapiens (human)1.167
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.36
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)1.083
Sodium-dependent serotonin transporterHomo sapiens (human)1.09
Histamine H1 receptorHomo sapiens (human)0.074
Mu-type opioid receptorHomo sapiens (human)2.272
D(3) dopamine receptorHomo sapiens (human)0.252
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.731
Sodium-dependent dopamine transporter Homo sapiens (human)1.641
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.04

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (26.09)18.2507
2000's9 (39.13)29.6817
2010's6 (26.09)24.3611
2020's2 (8.70)2.80

Authors

AuthorsStudies
Fu, SX; Jin, S; Li, YS; Wang, YL1
He, RR; Wang, YL4
Wang, YL; Yang, XP; Zhu, YH1
He, RR; Li, DP; Wang, YL; Xue, BJ; Zhang, YJ1
Bai, J; Wang, Y1
Wang, C; Want, YL; Zhang, YJ1
Guo, Y; Jia, QZ; Wang, YL; Zhang, HL; Zhang, YJ1
Du, YM; Liu, HC; Wang, YL1
Lü, P; Wang, YL; Zhang, GH1
Chen, ZY; Liu, LL; Liu, S; Wang, C; Wang, YL; Xu, YF; Zhang, YJ1
Dong, LF; Jia, QZ; Li, JX; Wang, YL; Yin, JX; Zhang, YJ1
Dong, L; Hu, H; Pei, T; Wang, Y; Xu, Y1
Wang, J; Yang, CQ; Zhang, ZW1
Du, Y; Guo, W; Kong, D; Shi, X; Wang, W; Wang, Y1
An, Z; Wang, J; Xu, X; Yang, C1
Lin, Y; Wang, J; Yang, C; Yang, H1
Guo, W; Li, J; Shi, X; Wang, W; Xiong, C1
Guo, W; Li, J; Shi, X; Wang, W; Zhang, W1
Guo, W; He, C; Li, S; Wang, H; Wang, T; Wang, X; Wang, Y1
Guo, W; Li, S; Liu, L; Wang, H; Wang, J; Wang, Y1

Other Studies

23 other study(ies) available for dipfluzine and cinnarizine

ArticleYear
Acute toxicity of dipfluzine and its effects on isolated vascular smooth muscle.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:1

    Topics: Animals; Aorta, Thoracic; Basilar Artery; Cinnarizine; Coronary Vessels; Female; In Vitro Techniques; Lethal Dose 50; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Swine

1990
Effect of dipfluzine on platelet aggregation and thrombus formation.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1994, Volume: 15, Issue:5

    Topics: Animals; Carotid Artery Thrombosis; Cinnarizine; Dose-Response Relationship, Drug; Female; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Wistar; Thrombosis

1994
Protective effect of dipfluzine on experimental brain edema in rats.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1994, Volume: 15, Issue:3

    Topics: Animals; Brain Edema; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Cinnarizine; Female; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar

1994
Selective vasodilatory effect of dipfluzine on vertebral artery in anesthetized dogs.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993, Volume: 14, Issue:2

    Topics: Animals; Cinnarizine; Coronary Vessels; Dogs; Female; Femoral Artery; Hemodynamics; Male; Vascular Resistance; Vasodilator Agents; Vertebral Artery

1993
Effects of dipfluzine on cortical somatosensory evoked potentials and amino acid contents in ischemic rat brain.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1996, Volume: 17, Issue:1

    Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cinnarizine; Evoked Potentials, Somatosensory; Excitatory Amino Acids; Female; Rats; Rats, Wistar

1996
Antagonistic effects of dipfluzine, flunarizine, and cinnarizine on 5-hydroxytryptamine-evoked contraction in pig basilar artery.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1996, Volume: 17, Issue:4

    Topics: Animals; Basilar Artery; Calcium Channel Blockers; Cinnarizine; Flunarizine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Serotonin Antagonists

1996
Effect of dipfluzine on L-type calcium current in guinea pig ventricular myocytes.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:8

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Separation; Cinnarizine; Female; Guinea Pigs; Heart Ventricles; Male; Membrane Potentials; Myocytes, Cardiac; Patch-Clamp Techniques

2001
[Effect of dipfluzine on acute ischemic brain edema in gerbils].
    Zhonghua yi xue za zhi, 2002, Aug-25, Volume: 82, Issue:16

    Topics: Acute Disease; Animals; Brain; Brain Edema; Brain Ischemia; Cinnarizine; Dose-Response Relationship, Drug; Female; Gerbillinae; Hippocampus; Male; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase; Water

2002
Effects of dipfluzine on delayed afterdepolarizations and triggered activity induced by ouabain in guinea pig papillary muscles.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:10

    Topics: Animals; Calcium; Calcium Channel Blockers; Cinnarizine; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Male; Microelectrodes; Neuromuscular Depolarizing Agents; Ouabain; Papillary Muscles

2002
Mechanism of anti-apoptotic action of dipfluzine on neuronal damage of the rat hippocampal CA1 region subjected to transient forebrain ischemia.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:2

    Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channel Blockers; Cinnarizine; Fas Ligand Protein; fas Receptor; Female; Hippocampus; Membrane Glycoproteins; Neurons; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Signal Transduction; Tumor Necrosis Factors

2005
[Metabolic pathways of dipfluzine in rats].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:2

    Topics: Animals; Benzophenones; Chromatography, Liquid; Cinnarizine; Female; Gas Chromatography-Mass Spectrometry; Glucuronides; Male; Rats; Rats, Wistar

2005
[Effects of dipfluzine on expressions of E-selectin, P-selectin, and ICAM-1 in brain ischemia-reperfusion rats].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:12

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Cinnarizine; Dose-Response Relationship, Drug; E-Selectin; Infarction, Middle Cerebral Artery; Intercellular Adhesion Molecule-1; Male; Neuroprotective Agents; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2005
Effect of dipfluzine on delayed afterdepolarizations and triggered activity induced by isoprenaline in human atrial fibers.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:2

    Topics: Action Potentials; Calcium Channel Blockers; Cinnarizine; Heart Atria; Humans; Isoproterenol; Microelectrodes; Purkinje Fibers

2006
Repression of FasL expression by dipfluzine involves a mechanism of inhibition of NFATc transactivation.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2008, Volume: 43, Issue:12

    Topics: Animals; Binding Sites; Calcium Channel Blockers; Cinnarizine; Fas Ligand Protein; Female; Hippocampus; I-kappa B Proteins; Ischemic Attack, Transient; Neurons; NF-kappa B; NF-KappaB Inhibitor alpha; NFATC Transcription Factors; Promoter Regions, Genetic; Protein Binding; Random Allocation; Rats; Rats, Sprague-Dawley; Transcriptional Activation

2008
Acute toxicity and toxicokinetics of dipfluzine hydrochloride, a novel calcium channel blocker.
    Regulatory toxicology and pharmacology : RTP, 2009, Volume: 54, Issue:1

    Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cinnarizine; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Male; Molecular Structure; No-Observed-Adverse-Effect Level; Rats; Rats, Sprague-Dawley; Tissue Distribution; Toxicity Tests, Acute

2009
[Synthesis and spectral characteristic of pharmaceutical dipfluzine hydrochloride-benzoic acid co-crystal].
    Guang pu xue yu guang pu fen xi = Guang pu, 2011, Volume: 31, Issue:9

    Topics: Benzoic Acid; Cinnarizine; Crystallization; Hydrogen Bonding; Spectrum Analysis

2011
Simultaneous determination of a novel diphenylpiperazine calcium channel blocker and its four metabolites in rat liver microsomes by liquid chromatography tandem mass spectrometry.
    Pharmacology, 2012, Volume: 89, Issue:3-4

    Topics: Animals; Calcium Channel Blockers; Chromatography, Liquid; Cinnarizine; Female; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sex Factors; Tandem Mass Spectrometry

2012
Use of the co-grinding method to enhance the dissolution behavior of a poorly water-soluble drug: generation of solvent-free drug-polymer solid dispersions.
    Chemical & pharmaceutical bulletin, 2012, Volume: 60, Issue:7

    Topics: Calorimetry, Differential Scanning; Cinnarizine; Particle Size; Pharmaceutical Preparations; Poloxamer; Polymers; Povidone; Solubility; Solvents; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Water

2012
Preparation, characterization, and evaluation of dipfluzine-benzoic acid co-crystals with improved physicochemical properties.
    Pharmaceutical research, 2014, Volume: 31, Issue:3

    Topics: Animals; Benzoic Acid; Calcium Channel Blockers; Calorimetry, Differential Scanning; Cinnarizine; Crystallization; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Solubility; Spectroscopy, Fourier Transform Infrared; Water; X-Ray Diffraction

2014
Pharmacokinetic evaluation of dipfluzine and its three metabolites in rat plasma using liquid chromatography-mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Feb-01, Volume: 947-948

    Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cinnarizine; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2014
Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride.
    Environmental toxicology and pharmacology, 2014, Volume: 38, Issue:3

    Topics: Animals; Calcium Channel Blockers; Chromatography, Liquid; Cinnarizine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2014
Vasodilation activity of dipfluzine metabolites in isolated rat basilar arteries and their underlying mechanisms.
    Environmental toxicology and pharmacology, 2020, Volume: 79

    Topics: Animals; Basilar Artery; Cinnarizine; Endothelium, Vascular; In Vitro Techniques; Male; Potassium Channels; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents

2020
Interactions between dipfluzine-based complexes and cytochrome P450 enzymes: Information on salt, cocrystal, and salt cocrystal complexes.
    Environmental toxicology and pharmacology, 2020, Volume: 80

    Topics: Cinnarizine; Crystallization; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; Salts

2020