cyclorphan and Cocaine-Related-Disorders

cyclorphan has been researched along with Cocaine-Related-Disorders* in 1 studies

Other Studies

1 other study(ies) available for cyclorphan and Cocaine-Related-Disorders

Article	Year
Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. Bioorganic & medicinal chemistry letters, 2001, Oct-22, Volume: 11, Issue:20 A series of new N-substituted derivatives of morphinan was synthesized and their binding affinity for the three opioid receptors (mu, delta, and kappa) was determined. A paradoxical effect of N-propargyl (MCL-117) and N-(3-iodoprop-(2E)-enyl) (MCL-118) substituents on the binding affinities for the mu and kappa opioid receptors was observed. All of these novel derivatives showed a preference for the mu and kappa versus delta binding. Topics: Cocaine-Related Disorders; Drug Combinations; Humans; Morphinans; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu	2001

Article

Year

Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan.

Bioorganic & medicinal chemistry letters, 2001, Oct-22, Volume: 11, Issue:20

A series of new N-substituted derivatives of morphinan was synthesized and their binding affinity for the three opioid receptors (mu, delta, and kappa) was determined. A paradoxical effect of N-propargyl (MCL-117) and N-(3-iodoprop-(2E)-enyl) (MCL-118) substituents on the binding affinities for the mu and kappa opioid receptors was observed. All of these novel derivatives showed a preference for the mu and kappa versus delta binding.

Topics: Cocaine-Related Disorders; Drug Combinations; Humans; Morphinans; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu

2001