Compounds > crotarbital
Page last updated: 2024-12-11

crotarbital

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

crotarbital: RN given refers to parent cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5364821
SCHEMBL ID712976
SCHEMBL ID2285746
MeSH IDM0040687

Synonyms (48)

Synonym
ethyl(crotyl)barbiturate
nsc125735
ethyl-crotyl-barbiturate
kalipnon
nsc-125735
mepertan
barbituric acid, 5-(2-butenyl)-5-ethyl-
crotarbital
barotal
go 1046
2,6(1h,3h,5h)-pyrimidinetrione, 5-(2-butenyl)-5-ethyl-
calypnone
barotalum
kalypnetten
1952-67-6
5-(2-butenyl)-5-ethylbarbituric acid
5-ethyl-5-crotylbarbituric acid
kalypnon
crotylbarbital
crotylbarbitalum
2,4,6(1h,3h,5h)-pyrimidinetrione, 5-(2-butenyl)-5-ethyl-
einecs 217-777-9
nsc 125735
ethyl (crotyl)barbiturate
5-(2-butenyl)-5-ethyl-1h,3h,5h-pyrimidine-2,4,6-trione
5-aethyl-5-crotylbarbitursaure [german]
5-[(e)-but-2-enyl]-5-ethyl-1,3-diazinane-2,4,6-trione
5-aethyl-5-crotylbarbitursaure
unii-sxw2hl5ju7
sxw2hl5ju7 ,
2,4,6(1h,3h,5h)-pyrimidinetrione, 5-(2-butenyl)-5-ethyl-, (e)-
crotarbital [who-dd]
crotylbarbitone
28360-89-6
5-crotyl-5-ethylbarbituric acid
2,4,6(1h,3h,5h)-pyrimidinetrione, 5-(2-buten-1-yl)-5-ethyl-
crotarbitone
go-1046
crotylbital
SCHEMBL712976
KNMOHCLEINXVBG-HWKANZROSA-N
5-[2-butenyl]-5-ethyl-2,4,6(1h,3h,5h)-pyrimidinetrione #
SCHEMBL2285746
HY-101629
CS-6573
(e)-crotylbarbital
Q5189013
AKOS040732215
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (87.50)18.7374
1990's1 (12.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (10.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
amitriptyline
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.. amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.		1.9610carbotricyclic compound;
tertiary amine		adrenergic uptake inhibitor;
antidepressant;
environmental contaminant;
tropomyosin-related kinase B receptor agonist;
xenobiotic
caffeine
[no description available]		3.7521purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
diazepam
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.		2.36201,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
glyburide
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide. glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.		1.9610monochlorobenzenes;
N-sulfonylurea		anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.		2.3720barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
promazine
Promazine: A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.. promazine : A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.		1.9610phenothiazines;
tertiary amine		antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
muscarinic antagonist;
phenothiazine antipsychotic drug;
serotonergic antagonist
pyrithyldione
pyrithyldione: structure		1.9710tetrahydropyridine
methaqualone
Methaqualone: A quinazoline derivative with hypnotic and sedative properties. It has been withdrawn from the market in many countries because of problems with abuse. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604). methaqualone : A member of the class of quinazolines that is quinazolin-4-one substituted at positions 2 and 3 by methyl and o-tolyl groups respectively. A depressant that increases the activity of the GABA receptors in the brain and nervous system, it is used as a sedative and hypnotic medication. It became popular as a recreational drug and club drug in the late 1960s and 1970s.		2.3720quinazolinesGABA agonist;
sedative
1,4-dihydropyridine
[no description available]		1.9610
dihydropyridines
Dihydropyridines: Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Mushroom Poisoning
Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.		01.9610
Poisoning
Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.		02.3620