crotarbital and Poisoning

Orthograde intestinal lavage was successfully used in the treatment of eight patients with acute poisoning. Three had mushroom (Amanita pantherina) poisoning, five acute drug intoxication (attempted suicide: diazepam, dihydropyridine, crotylbarbital, phenobarbital, amitriptyline and glibenclamide). Within 5-18 hours the clinical signs of poisoning regressed in four patient in stage IV (after Reed), so that the patients became responsive. Detoxication by orthograde intestinal lavage is achieved by mechanical removal of nonabsorbed compounds from the gastro-intestinal tract and via intestinal dialysis across the intestinal mucosa.

Topics: Amitriptyline; Barbiturates; Diazepam; Dihydropyridines; Glyburide; Humans; Intestines; Mushroom Poisoning; Phenobarbital; Poisoning; Posture; Pyridines; Suicide, Attempted; Therapeutic Irrigation

The capacities of the resins Wofatit Y 29, Y 55 and Y 56 (VEB Chemiekombinat Bitterfeld) to adsorb various medicaments were compared with that of the resin XAD-4. Methaquelone, diazepam, krotylbarbital, promazine phosphate and ethyloxamine were used as test substances. The resin Y 56 proved to have an adsorption capacity similar to that of XAD-4 (e.g. maximum saturation for methaquelone 98%, half-maximum saturation at 7 minutes). In further tests on various batches of this resin the best results were given by the resin Y 56/7. Adsorption was quite clearly shown to be dependent on concentration. At a blood-flow of 100 ml/min clearance values of 34.5 ml/min for krotylbarbitol and 22.1 ml/min for methaquelone were calculated. According to these findings the resin Y 56/7 is suitable for further testing in a haemoperfusion system with a view to clinical use.

Topics: Barbiturates; Diazepam; Hemoperfusion; Humans; Methaqualone; Poisoning; Promazine; Resins, Synthetic