4-hydrazinobenzoic acid profile

4-Hydrazinobenzoic acid (4-HBA) is an organic compound with the formula H2NNHC6H4COOH. It is a white solid that is soluble in water and ethanol. 4-HBA is used as a precursor to the synthesis of various pharmaceuticals, including hydralazine, a vasodilator used to treat high blood pressure. 4-HBA is also a building block for the preparation of polymers and other organic materials. The compound is known to exhibit anti-inflammatory and antioxidant properties, and its biological activities have been studied in various contexts. It is also an important intermediate in the synthesis of pharmaceuticals and other fine chemicals. Research on 4-HBA focuses on its applications in organic synthesis, its biological properties, and its potential as a precursor for new materials.'

4-hydrazinobenzoic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	12089
CHEMBL ID	3189010
SCHEMBL ID	7034
MeSH ID	M0150764

Synonym
HMS1787J10
AC-1781
BB 0220537
benzoic acid, p-hydrazino-
p-hydrazinobenzoic acid
p-carboxyphenylhydrazine
(4-carboxyphenyl)hydrazine
619-67-0
nsc-3813
benzoic acid, 4-hydrazino-
4-hydrazinobenzoic acid
nsc3813
brn 0387378
nsc 3813
einecs 210-609-5
ai3-21063
ccris 7911
4-hydrazinobenzoic acid, 97%
OPREA1_377686
inchi=1/c7h8n2o2/c8-9-6-3-1-5(2-4-6)7(10)11/h1-4,9h,8h2,(h,10,11
STK391437
4-hydrazinylbenzoic acid
H0800
AKOS000119274
A5051
A15703
NCGC00248560-01
NCGC00248560-02
4-hydrazinobenzoicacidhydrochloride
4-hydrazino benzoic acid
BBL008190
tox21_200198
NCGC00257752-01
cas-619-67-0
dtxcid10708
dtxsid3020708 ,
4-carboxyphenylhydrazine
unii-b1r368je7o
4-15-00-01372 (beilstein handbook reference)
b1r368je7o ,
benzoic acid, 4-hydrazinyl-
FT-0618608
(p-carboxyphenyl)hydrazine
deferasirox impurity f [ep impurity]
p-hydrazino benzoic acid
SCHEMBL7034
PS-5959
SY018304
mfcd00007581
Q-200475
F0865-0011
CHEMBL3189010
CS-W018098
BCP27403
EN300-17558
Q27274260
SB75849
HY-W017382
Z56957167

Protein Targets (17)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Luciferase	Photinus pyralis (common eastern firefly)	Potency	32.1457	0.0072	15.7588	89.3584	AID1224835
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	0.0983	0.0060	38.0041	19,952.5996	AID1159521; AID1159523
GLI family zinc finger 3	Homo sapiens (human)	Potency	37.0058	0.0007	14.5928	83.7951	AID1259368; AID1259369; AID1259392
AR protein	Homo sapiens (human)	Potency	32.1738	0.0002	21.2231	8,912.5098	AID1259243; AID1259247; AID743040; AID743042; AID743054
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	62.0019	0.0133	26.9810	70.7614	AID1346978
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	1.8154	0.0010	22.6508	76.6163	AID1224838; AID1224839; AID1224893
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	0.4211	0.0030	41.6115	22,387.1992	AID1159552; AID1159553; AID1159555
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	25.5445	0.0015	30.6073	15,848.9004	AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
pregnane X nuclear receptor	Homo sapiens (human)	Potency	0.0439	0.0054	28.0263	1,258.9301	AID1346982
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	5.1683	0.0002	29.3054	16,493.5996	AID1259244; AID1259248; AID743079; AID743080; AID743091
caspase-3	Homo sapiens (human)	Potency	62.0019	0.0133	26.9810	70.7614	AID1346978
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	55.2593	0.0007	23.0674	1,258.9301	AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	0.0553	0.0017	23.8393	78.1014	AID743083
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	0.0625	19.7391	45.9784	64.9432	AID1159509
histone deacetylase 9 isoform 3	Homo sapiens (human)	Potency	5.7845	0.0376	17.0823	61.1927	AID1259364; AID1259388
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	9.8266	0.0015	57.7890	15,848.9004	AID1259244
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	9.8266	0.0015	51.7393	15,848.9004	AID1259244
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Process	via Protein(s)	Taxonomy
plasma membrane	Glutamate receptor 2	Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1453183	Binding affinity to CK2alpha (unknown origin) assessed as change in melting temperature by thermal shift assay	2017	Bioorganic & medicinal chemistry, 07-01, Volume: 25, Issue:13	A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (10.00)	18.7374
1990's	1 (10.00)	18.2507
2000's	3 (30.00)	29.6817
2010's	4 (40.00)	24.3611
2020's	1 (10.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
protocatechuic acid protocatechuic acid: RN given refers to parent cpd; structure. 3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.	2.15	1	catechols; dihydroxybenzoic acid	antineoplastic agent; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor; human xenobiotic metabolite; plant metabolite
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2.06	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
phenylpyruvic acid phenylpyruvic acid: RN given refers to parent cpd. phenylpyruvate : A 2-oxo monocarboxylic acid anion resulting from deprotonation of the carboxy group of either keto- or enol-phenylpyruvic acid.. keto-phenylpyruvic acid : A 2-oxo monocarboxylic acid that is 3-phenylpropanoic acid substituted by an oxo group at position 2. It is an intermediate metabolite in the phenylalanine pathway.	2.15	1	2-oxo monocarboxylic acid	chromogenic compound; EC 6.4.1.1 (pyruvate carboxylase) inhibitor; fundamental metabolite
beta-resorcylic acid beta-resorcylic acid: RN given refers to parent cpd; structure	2.15	1
homovanillic acid Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.. homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.. homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.	2.15	1	guaiacols; monocarboxylic acid	human metabolite; mouse metabolite
5-fluoroindole-2-carboxylic acid 5-fluoroindole-2-carboxylic acid: N-methyl-D-aspartate receptor antagonist	2.15	1	indolyl carboxylic acid
chromone-2-carboxylic acid [no description available]	2.15	1	chromones
5-methylsalicylic acid [no description available]	2.15	1
quinaldic acid [no description available]	2.15	1	quinolinemonocarboxylic acid	human metabolite; Saccharomyces cerevisiae metabolite
3-aminobenzoic acid 3-aminobenzoic acid: RN given refers to parent cpd. 3-aminobenzoic acid : An aminobenzoic acid carrying an amino group at position 3.	2.15	1	aminobenzoic acid
hydrazine diamine : Any polyamine that contains two amino groups.	1.99	1	azane; hydrazines	EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
dipicolinic acid dipicolinic acid : A pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6.	2.15	1	pyridinedicarboxylic acid	bacterial metabolite
phloretic acid phloretic acid: structure. N-hydroxysuccinimide ester : An ester of N-hydroxysuccinimide.. phloretic acid : A hydroxy monocarboxylic acid consisting of propionic acid having a 4-hydroxyphenyl group at the 3-position.	2.15	1	hydroxy monocarboxylic acid	plant metabolite
acetylglucosamine Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.	2	1	N-acetyl-D-glucosamine	epitope
galactose aldohexose : A hexose with a (potential) aldehyde group at one end.	2	1
chlorodiphenyl (54% chlorine) Chlorodiphenyl (54% Chlorine): A mixture of polychlorinated biphenyls that induces hepatic microsomal UDP-glucuronyl transferase activity towards thyroxine.. Aroclor 1254 : A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).	1.99	1
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	2.03	1	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
4-hydroxybenzamide [no description available]	2.15	1
2-hydroxynicotinic acid [no description available]	2.15	1	aromatic carboxylic acid; pyridines
arabinose [no description available]	2	1	L-arabinose	Escherichia coli metabolite; mouse metabolite
agaritine [no description available]	1.99	1	amino acid zwitterion; benzyl alcohols; carbohydrazide; L-glutamic acid derivative; non-proteinogenic L-alpha-amino acid
laminaran laminaran: beta-1,3-glucan	2	1
acebutolol alpha-D-glucosyl-(1->4)-alpha-D-mannose : An alpha-D-glucosyl-(1->4)-D-mannopyranose in which the anomeric hydroxy group has alpha configuration.	2	1	alpha-D-glucosyl-(1->4)-D-mannopyranose
4-hydroxycoumarin 2-hydroxychromone: structure	2.15	1	hydroxycoumarin
deoxyguanosine [no description available]	2.03	1	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanosine ribonucleoside : Any nucleoside where the sugar component is D-ribose.	2.03	1	guanosines; purines D-ribonucleoside	fundamental metabolite
8-hydroxy-2'-deoxyguanosine 8-Hydroxy-2'-Deoxyguanosine: Common oxidized form of deoxyguanosine in which C-8 position of guanine base has a carbonyl group.. 8-hydroxy-2'-deoxyguanosine : Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.	2.03	1	guanosines	biomarker

Condition	Relationship Strength	Studies
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1
Hepatocellular Carcinoma [description not available]	2.06	1
Cancer of Liver [description not available]	2.06	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.06	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.06	1
Fibroid [description not available]	1.97	1
Leiomyosarcoma, Epithelioid [description not available]	1.97	1
Aortic Aneurysm, Ruptured [description not available]	1.97	1
Muscle Tissue Neoplasms [description not available]	1.97	1
Aortic Diseases Pathological processes involving any part of the AORTA.	1.97	1
Leiomyoma A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.	1.97	1
Leiomyosarcoma A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)	1.97	1

4-hydrazinobenzoic acid

Description

Cross-References

Synonyms (59)

Protein Targets (17)

Potency Measurements

Ceullar Components (1)

Bioassays (3)

Research

Studies (10)

Market Indicators

Research Demand Index: 34.13

Study Types

4-hydrazinobenzoic acid

Description

Cross-References

Synonyms (59)

Protein Targets (17)

Potency Measurements

Ceullar Components (1)

Bioassays (3)

Research

Studies (10)

Market Indicators

Research Demand Index: 34.13

Study Types

Related Drugs (27)

Related Conditions (13)