3,3'-dichlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

3,3'-Dichlorobiphenyl (PCB 15) is a polychlorinated biphenyl (PCB) congener. PCBs are synthetic organic compounds that were widely used in industrial applications due to their chemical stability, non-flammability, and electrical insulating properties. However, PCBs are persistent environmental pollutants and have been linked to a range of adverse health effects, including cancer, reproductive problems, and developmental delays. 3,3'-dichlorobiphenyl is a relatively less chlorinated PCB congener, meaning it has a lower number of chlorine atoms attached to the biphenyl molecule. This makes it more volatile and susceptible to environmental degradation compared to highly chlorinated congeners. 3,3'-dichlorobiphenyl has been found in various environmental compartments, including soil, water, and air. Its presence in the environment is primarily attributed to historical releases from industrial activities, such as manufacturing, waste disposal, and accidental spills. Due to its persistence and potential health risks, 3,3'-dichlorobiphenyl has been the subject of numerous studies focusing on its environmental fate, toxicity, and potential for bioaccumulation in living organisms. These studies aim to understand the pathways of exposure to 3,3'-dichlorobiphenyl and its potential impact on human and ecosystem health. 3,3'-dichlorobiphenyl is also used as a model compound for studying the biotransformation and metabolism of PCBs in organisms. Its relatively simple structure and the availability of analytical methods make it a suitable target for investigating the role of different enzymes and pathways involved in PCB detoxification. These studies can provide valuable insights into the mechanisms of PCB toxicity and aid in the development of strategies for managing PCB contamination. '

Cross-References

ID Source	ID
PubMed CID	16307
SCHEMBL ID	817554
MeSH ID	M0095055

Synonyms (31)

Synonym
pcb 11
pcb-11 cpd
1,1'-biphenyl, 3,3'-dichloro-
biphenyl, 3,3'-dichloro-
clophen a 30
55600-34-5
clophen a-30
ccris 5871
clophen a30
inchi=1/c12h8cl2/c13-11-5-1-3-9(7-11)10-4-2-6-12(14)8-10/h1-8
2050-67-1
3,3'-dichlorobiphenyl
3,3'-dichloro-1,1'-biphenyl
1-chloro-3-(3-chlorophenyl)benzene
clophen 30
62u12s7cjz ,
unii-62u12s7cjz
AKOS015903462
m,m'-dichlorobiphenyl
3,3'-dcb
SCHEMBL817554
3,3'-dichlorodiphenyl
3,3'-dichloro-1,1'-biphenyl #
DTXSID70872817
pcb no 11, analytical standard
pcb no. 11 10 microg/ml in isooctane
pcb no. 11
3,3/'-dichlorobiphenyl
AMY450
Q27263514
m,m'-dichlordiphenyl

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (6.67)	18.7374
1990's	4 (13.33)	18.2507
2000's	6 (20.00)	29.6817
2010's	13 (43.33)	24.3611
2020's	5 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	16.71 (24.57)
Research Supply Index	3.47 (2.92)
Research Growth Index	4.99 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (16.71)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.23%)	6.00%
Case Studies	1 (3.23%)	4.05%
Observational	0 (0.00%)	0.25%
Other	29 (93.55%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	2.41	1	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
benzo(a)pyrene Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.	2.25	1	ortho- and peri-fused polycyclic arene	carcinogenic agent; mouse metabolite
3,3'-dichlorobenzidine 3,3'-Dichlorobenzidine: A material used in the manufacture of azo dyes that is toxic to skin and carcinogenic in several species.	2.05	1	biphenyls; monochlorobenzenes; organochlorine compound
diphenyl diphenyl: RN given refers to unlabeled cpd; structure	2.41	2	aromatic fungicide; benzenes; biphenyls	antifungal agrochemical; antimicrobial food preservative
4,4'-dichlorobiphenyl 4,4'-dichlorobiphenyl : A dichlorobiphenyl carrying chloro groups at positions 4 and 4' respectively.	2.38	2	dichlorobiphenyl; monochlorobenzenes
2,4,4'-trichlorobiphenyl [no description available]	2.49	2
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	2.04	1	diatomic chlorine; gas molecular entity	bleaching agent
2,2'-dichlorobiphenyl [no description available]	2.41	2
2,4',5-trichlorobiphenyl [no description available]	2.01	1
3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl: RN given refers to parent cpd. 3,3',4,4'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which the hydrogens at position 3 and 4 on each phenyl group are replaced by chlorines.	2.42	2	dichlorobenzene; tetrachlorobiphenyl
pcb 74 [no description available]	2.08	1
2,5-dichlorobiphenyl 2,5-dichlorobiphenyl : A dichlorobiphenyl that is p-dichlorobenzene in which one of the hydrogens has been replaced by a phenyl group.	2.38	2	dichlorobenzene; dichlorobiphenyl
3,5-dichlorobiphenyl 3,5-dichlorobiphenyl : A dichlorobiphenyl that is 1,3-dichlorobenzene in which the hydrogen at position 5 has been replaced by a phenyl group.	1.96	1	dichlorobenzene; dichlorobiphenyl
2,4'-dichlorobiphenyl 2,4'-dichlorobiphenyl: RN given refers to unlabeled cpd. 2,4'-dichlorobiphenyl : A dichlorobiphenyl that is chlorobenzene in which the hydrogen at position 2 has been replaced by a 4-chlorophenyl group.	1.96	1	dichlorobiphenyl; monochlorobenzenes
2,4,5,2',4',5'-hexachlorobiphenyl [no description available]	2.31	1	hexachlorobiphenyl
2,5,2',5'-tetrachlorobiphenyl 2,2',5,5'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which the hydrogens at the 2 and 5 position of each benzene ring are replaced by chlorines.	2.93	4	dichlorobenzene; tetrachlorobiphenyl
2,2',5-trichlorobiphenyl [no description available]	2.4	2
2,4,5,2',5'-pentachlorobiphenyl [no description available]	1.97	1
2,2',3,5',6-pentachlorobiphenyl [no description available]	2.08	1
2-phosphonobutane-1,2,4-tricarboxylic acid 2-phosphonobutane-1,2,4-tricarboxylic acid: dental plaque crystal growth inhibitor; RN given for parent cpd; structure given in first source	2.05	1
3,4,5,3',4'-pentachlorobiphenyl 3,3',4,4',5-pentachlorobiphenyl : A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.	2.63	2	pentachlorobiphenyl; trichlorobenzene
glucuronic acid Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.. D-glucuronic acid : The D-enantiomer of glucuronic acid.. D-glucopyranuronic acid : A D-glucuronic acid in cyclic pyranose form.	2.15	1	D-glucuronic acid	algal metabolite
1-hexadecyl-2-acetyl-glycero-3-phosphocholine Platelet Activating Factor: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.. 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine : A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.	1.97	1	2-acetyl-1-alkyl-sn-glycero-3-phosphocholine	antihypertensive agent; beta-adrenergic antagonist; bronchoconstrictor agent; hematologic agent; vasodilator agent
12-hydroxy-5,8,10,14-eicosatetraenoic acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid: A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)	1.97	1

Condition	Relationship Strength	Studies
Cancer of Liver [description not available]	1.96	1
Experimental Neoplasms [description not available]	1.96	1
Carcinoma, Thymic [description not available]	1.96	1
Cancer of the Thymus [description not available]	1.96	1
Genito-urinary Cancer [description not available]	1.96	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.96	1
Thymoma A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)	1.96	1
Thymus Neoplasms Tumors or cancer of the THYMUS GLAND.	1.96	1
Urogenital Neoplasms Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.	1.96	1
Encephalopathy, Toxic [description not available]	2.31	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.63	2

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