Compounds > 4,4'-dichlorobiphenyl
Page last updated: 2024-09-22

4,4'-dichlorobiphenyl

Description

4,4'-dichlorobiphenyl : A dichlorobiphenyl carrying chloro groups at positions 4 and 4' respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID16308
CHEMBL ID14295
CHEBI ID34364
SCHEMBL ID28215
MeSH IDM0094938

Synonyms (47)

Synonym
BIDD:ER0410
AC-20957
4,4'-dichloro-1,1'-biphenyl
CHEBI:34364 ,
biphenyl, 4,4'-dichloro-
1,1'-biphenyl, 4,4'-dichloro-
inchi=1/c12h8cl2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8
ai3-09066
einecs 218-095-4
nsc 1141
pcb 15
biphenyl,4'-dichloro-
nsc1141
p,p'-dichlorobiphenyl
nsc-1141
1, 4,4'-dichloro-
4,4'-dichlorobiphenyl
p,p-dcbp
2050-68-2
MAYBRIDGE4_001889
SR-01000640957-1
NCGC00177150-01
4-dcb cpd
HMS1526F19
4,4'-dichloro-biphenyl
CHEMBL14295
1-chloro-4-(4-chlorophenyl)benzene
1-chloro-4-(4-chlorophenyl)-benzene
dof6s5dt2r ,
unii-dof6s5dt2r
132567-22-7
CCG-51668
STL280366
FT-0617038
AKOS015903435
SCHEMBL28215
DTXSID0022515 ,
4,4'-pcb, 98%
pcb no 15, analytical standard
pcb no. 15
4-4'-dichlorobiphenyl
mfcd00013641
Q27116020
4,4/'-dichlorobiphenyl
AMY13460
4,4'-dicb
dtxcid502515

Drug Classes (2)

ClassDescription
dichlorobiphenylAny polychlorobiphenyl with molecular formula C12H8Cl2.
monochlorobenzenesAny member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID23673Partition coefficient (logP)2002Bioorganic & medicinal chemistry letters, Apr-08, Volume: 12, Issue:7
Novel estimation of lipophilic behaviour of polychlorinated biphenyls.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (35.71)18.7374
1990's3 (10.71)18.2507
2000's8 (28.57)29.6817
2010's5 (17.86)24.3611
2020's2 (7.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other29 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
diphenyl[no description available]medium30aromatic fungicide;
benzenes;
biphenyls		antifungal agrochemical;
antimicrobial food preservative
decachlorobiphenyl[no description available]medium10pentachlorobenzenes;
polychlorobiphenyl
4-chlorobiphenyl[no description available]medium40monochlorobiphenyl
2,2'-dichlorobiphenyl[no description available]medium40
3,4,5,3',4',5'-hexachlorobiphenyl[no description available]medium10hexachlorobiphenyl;
trichlorobenzene
2,3,4,5-tetrachlorobiphenyl[no description available]medium10tetrachlorobenzene;
tetrachlorobiphenyl
2,4,5,2',4',5'-hexachlorobiphenyl[no description available]medium30hexachlorobiphenyl
2,5,2',5'-tetrachlorobiphenyl[no description available]medium20dichlorobenzene;
tetrachlorobiphenyl
2,2',5-trichlorobiphenyl[no description available]medium20
2,4,5,2',5'-pentachlorobiphenyl[no description available]medium10
n-benzoyl-n-phenylhydroxylamine[no description available]medium10
2,4,2',4'-tetrachlorobiphenyl[no description available]medium20dichlorobenzene;
tetrachlorobiphenyl
hydroxyl radical[no description available]medium10oxygen hydride;
oxygen radical;
reactive oxygen species
2,4,4'-trichlorobiphenyl[no description available]medium10
chlorine[no description available]medium30diatomic chlorine;
gas molecular entity		bleaching agent
goethite[no description available]medium10
fenton's reagent[no description available]medium10
2,4,6,2',4',6'-hexachlorobiphenyl[no description available]medium10hexachlorobiphenyl;
trichlorobenzene
chlorine[no description available]medium10halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
kc 400[no description available]medium20dichlorobenzene;
tetrachlorobiphenyl
2,4'-dichlorobiphenyl[no description available]medium10dichlorobiphenyl;
monochlorobenzenes
3,3'-dichlorobiphenyl[no description available]medium20
3,5-dichlorobiphenyl[no description available]medium20dichlorobenzene;
dichlorobiphenyl
2,5-dichlorobiphenyl[no description available]medium10dichlorobenzene;
dichlorobiphenyl
3,4,3',4'-tetrachlorobiphenyl[no description available]medium20dichlorobenzene;
tetrachlorobiphenyl
sphingosine[no description available]medium10sphing-4-eninehuman metabolite;
mouse metabolite
2,4',5-trichlorobiphenyl[no description available]medium10
atrazine[no description available]medium10chloro-1,3,5-triazine;
diamino-1,3,5-triazine		environmental contaminant;
herbicide;
xenobiotic
4,4'-dibromobiphenyl[no description available]medium10
pregnenolone carbonitrile[no description available]medium10aliphatic nitrile
acetaminophen[no description available]medium20acetamides;
phenols		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
phenobarbital[no description available]medium30barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
aspirin[no description available]medium10benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
salicylates[no description available]medium10monohydroxybenzoateplant metabolite
3-methylcholanthrene[no description available]medium10ortho- and peri-fused polycyclic arenearyl hydrocarbon receptor agonist;
carcinogenic agent
phenacetin[no description available]medium10acetamides;
aromatic ether		cyclooxygenase 3 inhibitor;
non-narcotic analgesic;
peripheral nervous system drug
dinitrochlorobenzene[no description available]low00C-nitro compound;
monochlorobenzenes		allergen;
epitope;
sensitiser
bupropion[no description available]low00aromatic ketone;
monochlorobenzenes;
secondary amino compound		antidepressant;
environmental contaminant;
xenobiotic
pk 11195[no description available]low00aromatic amide;
isoquinolines;
monocarboxylic acid amide;
monochlorobenzenes		antineoplastic agent
1-(3-chlorophenyl)biguanide[no description available]low00biguanides;
monochlorobenzenes
1-(3-chlorophenyl)piperazine[no description available]low00monochlorobenzenes;
N-arylpiperazine		drug metabolite;
environmental contaminant;
serotonergic agonist;
xenobiotic
chlorocresol[no description available]low00hydroxytoluene;
monochlorobenzenes		antimicrobial agent;
disinfectant;
ryanodine receptor agonist
win 53338[no description available]low00isoxazoles;
monochlorobenzenes		antiviral agent
acemetacin[no description available]low00carboxylic ester;
indol-3-yl carboxylic acid;
monocarboxylic acid;
monochlorobenzenes;
N-acylindole		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug
rtki cpd[no description available]low00aromatic ether;
monochlorobenzenes;
quinazolines		antineoplastic agent;
antiviral agent;
epidermal growth factor receptor antagonist;
geroprotector
amlodipine[no description available]low00dihydropyridine;
ethyl ester;
methyl ester;
monochlorobenzenes;
primary amino compound		antihypertensive agent;
calcium channel blocker;
vasodilator agent
azelastine[no description available]low00monochlorobenzenes;
phthalazines;
tertiary amino compound		anti-allergic agent;
anti-asthmatic drug;
bronchodilator agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
H1-receptor antagonist;
platelet aggregation inhibitor
azosemide[no description available]low00monochlorobenzenes;
sulfonamide;
tetrazoles;
thiophenes		loop diuretic
baclofen[no description available]low00amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid;
monochlorobenzenes;
primary amino compound		central nervous system depressant;
GABA agonist;
muscle relaxant
carbinoxamine[no description available]low00monochlorobenzenes;
pyridines;
tertiary amino compound		anti-allergic agent;
antiparkinson drug;
H1-receptor antagonist;
muscarinic antagonist
carbonyl cyanide m-chlorophenyl hydrazone[no description available]low00hydrazone;
monochlorobenzenes;
nitrile		antibacterial agent;
geroprotector;
ionophore
cetirizine[no description available]low00ether;
monocarboxylic acid;
monochlorobenzenes;
piperazines		anti-allergic agent;
environmental contaminant;
H1-receptor antagonist;
xenobiotic
chlorhexidine[no description available]low00biguanides;
monochlorobenzenes		antibacterial agent;
antiinfective agent
chlormezanone[no description available]low001,3-thiazine;
lactam;
monochlorobenzenes;
sulfone		antipsychotic agent;
anxiolytic drug;
muscle relaxant
chloroxylenol[no description available]low00monochlorobenzenes;
phenols		antiseptic drug;
disinfectant;
molluscicide
chlorphenesin carbamate[no description available]low00carbamate ester;
monochlorobenzenes;
secondary alcohol		muscle relaxant
chlorpheniramine[no description available]low00monochlorobenzenes;
pyridines;
tertiary amino compound		anti-allergic agent;
antidepressant;
antipruritic drug;
H1-receptor antagonist;
histamine antagonist;
serotonin uptake inhibitor
chlorpropamide[no description available]low00monochlorobenzenes;
N-sulfonylurea		hypoglycemic agent;
insulin secretagogue
chlorpropham[no description available]low00benzenes;
carbamate ester;
monochlorobenzenes		herbicide;
plant growth retardant
chlorthalidone[no description available]low00isoindoles;
monochlorobenzenes;
sulfonamide
clemizole[no description available]low00benzimidazoles;
monochlorobenzenes;
pyrrolidines		histamine antagonist
clofazimine[no description available]low00monochlorobenzenes;
phenazines		dye;
leprostatic drug;
non-steroidal anti-inflammatory drug
clofibrate[no description available]low00aromatic ether;
ethyl ester;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist
clofibric acid[no description available]low00aromatic ether;
monocarboxylic acid;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
antineoplastic agent;
herbicide;
marine xenobiotic metabolite;
PPARalpha agonist
clonazepam[no description available]low001,4-benzodiazepinone;
monochlorobenzenes		anticonvulsant;
anxiolytic drug;
GABA modulator
clorprenaline[no description available]low00ethanolamines;
monochlorobenzenes;
secondary amino compound
clotrimazole[no description available]low00conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		antiinfective agent;
environmental contaminant;
xenobiotic
croconazole[no description available]low00aromatic ether;
conazole antifungal drug;
imidazole antifungal drug;
monochlorobenzenes
dichlorodiphenyl dichloroethylene[no description available]low00chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
ddt[no description available]low00benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
econazole[no description available]low00dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes
fenofibrate[no description available]low00aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes		antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic
fenvalerate[no description available]low00aromatic ether;
carboxylic ester;
monochlorobenzenes		pyrethroid ester acaricide;
pyrethroid ester insecticide
glyburide[no description available]low00monochlorobenzenes;
N-sulfonylurea		anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
haloperidol[no description available]low00aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
hydroxyzine[no description available]low00hydroxyether;
monochlorobenzenes;
N-alkylpiperazine		anticoronaviral agent;
antipruritic drug;
anxiolytic drug;
dermatologic drug;
H1-receptor antagonist
indomethacin[no description available]low00aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
ketamine[no description available]low00cyclohexanones;
monochlorobenzenes;
secondary amino compound		analgesic;
environmental contaminant;
intravenous anaesthetic;
neurotoxin;
NMDA receptor antagonist;
xenobiotic
lofepramine[no description available]low00aromatic ketone;
dibenzoazepine;
monochlorobenzenes;
tertiary amino compound		antidepressant
loperamide[no description available]low00monocarboxylic acid amide;
monochlorobenzenes;
piperidines;
tertiary alcohol		anticoronaviral agent;
antidiarrhoeal drug;
mu-opioid receptor agonist
metoclopramide[no description available]low00benzamides;
monochlorobenzenes;
substituted aniline;
tertiary amino compound		antiemetic;
dopaminergic antagonist;
environmental contaminant;
gastrointestinal drug;
xenobiotic
moclobemide[no description available]low00benzamides;
monochlorobenzenes;
morpholines		antidepressant;
environmental contaminant;
xenobiotic
nefazodone[no description available]low00aromatic ether;
monochlorobenzenes;
N-alkylpiperazine;
N-arylpiperazine;
triazoles		alpha-adrenergic antagonist;
analgesic;
antidepressant;
serotonergic antagonist;
serotonin uptake inhibitor
nemonapride[no description available]low00benzamides;
monochlorobenzenes;
monomethoxybenzene;
N-alkylpyrrolidine;
secondary amino compound;
secondary carboxamide;
substituted aniline
niclosamide[no description available]low00benzamides;
C-nitro compound;
monochlorobenzenes;
salicylanilides;
secondary carboxamide		anthelminthic drug;
anticoronaviral agent;
antiparasitic agent;
apoptosis inducer;
molluscicide;
piscicide;
STAT3 inhibitor
ag 1879[no description available]low00aromatic amine;
monochlorobenzenes;
pyrazolopyrimidine		beta-adrenergic antagonist;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
geroprotector
proglumetacin[no description available]low00aromatic ether;
benzamides;
carboxylic ester;
monochlorobenzenes;
N-acylindole;
N-alkylpiperazine		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
lipoxygenase inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug
pyrimethamine[no description available]low00aminopyrimidine;
monochlorobenzenes		antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
sulconazole[no description available]low00dichlorobenzene;
imidazoles;
monochlorobenzenes;
organic sulfide
ticlopidine[no description available]low00monochlorobenzenes;
thienopyridine		anticoagulant;
fibrin modulating drug;
hematologic agent;
P2Y12 receptor antagonist;
platelet aggregation inhibitor
trazodone[no description available]low00monochlorobenzenes;
N-alkylpiperazine;
N-arylpiperazine;
triazolopyridine		adrenergic antagonist;
antidepressant;
anxiolytic drug;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor
triclosan[no description available]low00aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
zomepirac[no description available]low00aromatic ketone;
monocarboxylic acid;
monochlorobenzenes;
pyrroles		cardiovascular drug;
non-steroidal anti-inflammatory drug
dichlorodiphenyldichloroethane[no description available]low00chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		xenobiotic metabolite
systhane[no description available]low00monochlorobenzenes;
nitrile;
triazoles
buclizine[no description available]low00monochlorobenzenes;
N-alkylpiperazine		antiemetic;
central nervous system depressant;
cholinergic antagonist;
histamine antagonist;
local anaesthetic
bis(p-chlorophenyl)acetic acid[no description available]low00monocarboxylic acid;
monochlorobenzenes
1-chloro-2-nitrobenzene[no description available]low00C-nitro compound;
monochlorobenzenes
picryl chloride[no description available]low00C-nitro compound;
monochlorobenzenes		allergen;
epitope;
explosive;
hapten
3,3'-dichlorobenzidine[no description available]low00biphenyls;
monochlorobenzenes;
organochlorine compound
mecoprop[no description available]low00aromatic ether;
monocarboxylic acid;
monochlorobenzenes
2-methyl-4-chlorophenoxyacetic acid[no description available]low00chlorophenoxyacetic acid;
monochlorobenzenes		environmental contaminant;
phenoxy herbicide;
synthetic auxin
2-methyl-4-chlorophenoxy gamma-butyric acid[no description available]low00aromatic ether;
monocarboxylic acid;
monochlorobenzenes		environmental contaminant;
phenoxy herbicide;
xenobiotic
3-chloro-4-methylaniline[no description available]low00chloroaniline;
monochlorobenzenes		avicide
4-chloro-1,2-diaminobenzene[no description available]low00monochlorobenzenes
fentichlor[no description available]low00aryl sulfide;
bridged diphenyl antifungal drug;
monochlorobenzenes;
polyphenol		antiinfective agent;
drug allergen
dyrene[no description available]low00monochlorobenzenes;
organochlorine pesticide;
secondary amino compound;
triazines		antifungal agrochemical
triclocarban[no description available]low00dichlorobenzene;
monochlorobenzenes;
phenylureas		antimicrobial agent;
antiseptic drug;
disinfectant;
environmental contaminant;
xenobiotic
barban[no description available]low00acetylenic compound;
carbamate ester;
monochlorobenzenes		herbicide
chlorphenesin[no description available]low00glycol;
monochlorobenzenes;
propane-1,2-diols		antibacterial drug;
antifungal drug;
muscle relaxant
4-chlorotoluene[no description available]low00monochlorobenzenes
4-chloroaniline[no description available]low00chloroaniline;
monochlorobenzenes
chlorobenzene[no description available]low00monochlorobenzenessolvent
dicofol[no description available]low00monochlorobenzenes;
organochlorine acaricide;
tertiary alcohol
tetradifon[no description available]low00monochlorobenzenes;
organochlorine acaricide;
sulfone;
trichlorobenzene
chloroprocaine[no description available]low00benzoate ester;
monochlorobenzenes		central nervous system depressant;
local anaesthetic;
peripheral nervous system drug
monuron[no description available]low003-(3,4-substituted-phenyl)-1,1-dimethylurea;
monochlorobenzenes		environmental contaminant;
herbicide;
xenobiotic
5-chlorosalicylic acid[no description available]low00chlorobenzoic acid;
monochlorobenzenes;
monohydroxybenzoic acid
cloflucarban[no description available]low00monochlorobenzenes;
phenylureas		antibacterial agent
4-chloroacetanilide[no description available]low00acetamides;
monochlorobenzenes
pyrrolnitrin[no description available]low00alkaloid;
C-nitro compound;
monochlorobenzenes;
pyrroles		antifungal drug;
bacterial metabolite
4-chloro-2-cresol[no description available]low00monochlorobenzenes;
phenols
4-chlorophenylacetic acid[no description available]low00monocarboxylic acid;
monochlorobenzenes		xenobiotic metabolite
4-chlorocatechol[no description available]low00chlorocatechol;
monochlorobenzenes		bacterial xenobiotic metabolite
2-chloro-4-aminobenzoic acid[no description available]low00aminobenzoic acid;
monochlorobenzenes
ddms[no description available]low00chlorophenylethane;
monochlorobenzenes
4-bromo-2-chlorophenol[no description available]low00halophenol;
monochlorobenzenes;
organobromine compound
3-chlorocatechol[no description available]low00chlorocatechol;
monochlorobenzenes
4-chlorophenoxyacetic acid[no description available]low00chlorophenoxyacetic acid;
monochlorobenzenes		phenoxy herbicide
clemastine[no description available]low00monochlorobenzenes;
N-alkylpyrrolidine		anti-allergic agent;
antipruritic drug;
H1-receptor antagonist;
muscarinic antagonist
chlortoluron[no description available]low00monochlorobenzenes;
phenylureas		agrochemical;
environmental contaminant;
herbicide;
xenobiotic
methoxuron[no description available]low003-(3,4-substituted-phenyl)-1,1-dimethylurea;
monochlorobenzenes;
monomethoxybenzene		agrochemical;
environmental contaminant;
herbicide;
photosystem-II inhibitor;
plant growth regulator;
xenobiotic
alclofenac[no description available]low00aromatic ether;
monocarboxylic acid;
monochlorobenzenes		drug allergen;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
benthiocarb[no description available]low00monochlorobenzenes;
monothiocarbamic ester
diflubenzuron[no description available]low00benzoylurea insecticide;
monochlorobenzenes		insect sterilant
climbazole[no description available]low00aromatic ether;
hemiaminal ether;
imidazoles;
ketone;
monochlorobenzenes
profenofos[no description available]low00monochlorobenzenes;
organic thiophosphate;
organochlorine insecticide;
organophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
bezafibrate[no description available]low00aromatic ether;
monocarboxylic acid amide;
monocarboxylic acid;
monochlorobenzenes		antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic
triadimefon[no description available]low00aromatic ether;
hemiaminal ether;
ketone;
monochlorobenzenes;
triazoles
benoxaprofen[no description available]low001,3-benzoxazoles;
monocarboxylic acid;
monochlorobenzenes		antipsoriatic;
antipyretic;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
hepatotoxic agent;
nephrotoxin;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
protein kinase C agonist
triadimenol[no description available]low00aromatic ether;
conazole fungicide;
hemiaminal ether;
monochlorobenzenes;
secondary alcohol;
triazole fungicide		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor;
xenobiotic metabolite
closantel[no description available]low00aromatic amide;
monocarboxylic acid amide;
monochlorobenzenes;
nitrile;
organoiodine compound;
phenols
fenarimol[no description available]low00monochlorobenzenes;
pyrimidines;
tertiary alcohol
triflumuron[no description available]low00aromatic ether;
benzoylurea insecticide;
monochlorobenzenes;
organofluorine compound
butoconazole[no description available]low00aryl sulfide;
conazole antifungal drug;
dichlorobenzene;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes
chlorsulfuron[no description available]low00methoxy-1,3,5-triazine;
monochlorobenzenes;
N-sulfonylurea		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
fluvalinate[no description available]low00(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
nitrile;
organochlorine acaricide;
organochlorine insecticide;
organofluorine acaricide;
organofluorine insecticide		agrochemical;
pyrethroid ester acaricide;
pyrethroid ester insecticide
fomesafen[no description available]low00aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-sulfonylcarboxamide;
organofluorine compound;
phenols		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
2,3,4,4'5-pentachlorobiphenyl[no description available]low00monochlorobenzenes;
pentachlorobiphenyl;
tetrachlorobenzene
clomazone[no description available]low00isoxazolidinone;
monochlorobenzenes		agrochemical;
carotenoid biosynthesis inhibitor;
environmental contaminant;
herbicide;
xenobiotic
tepoxalin[no description available]low00aromatic ether;
hydroxamic acid;
monochlorobenzenes;
pyrazoles		antipyretic;
apoptosis inhibitor;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
immunomodulator;
lipoxygenase inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
clopidogrel[no description available]low00methyl ester;
monochlorobenzenes;
thienopyridine		anticoagulant;
P2Y12 receptor antagonist;
platelet aggregation inhibitor
eliprodil[no description available]low00monochlorobenzenes;
monofluorobenzenes;
piperidines;
secondary alcohol;
tertiary amino compound
fluazuron[no description available]low00aromatic ether;
chloropyridine;
monochlorobenzenes;
N-acylurea;
organochlorine acaricide;
organofluorine acaricide;
phenylureas		acaricide;
mite growth regulator
flucofuron[no description available]low00(trifluoromethyl)benzenes;
monochlorobenzenes;
organochlorine pesticide;
organofluorine pesticide;
phenylureas		epitope
lonazolac[no description available]low00monocarboxylic acid;
monochlorobenzenes;
pyrazoles		antineoplastic agent;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
3-chloroperbenzoic acid[no description available]low00monochlorobenzenes;
peroxy acid
clofentezine[no description available]low00monochlorobenzenes;
organochlorine acaricide;
tetrazine		mite growth regulator;
tetrazine acaricide
tebuconazole[no description available]low00monochlorobenzenes;
tertiary alcohol;
triazoles
cyproconazole[no description available]low00cyclopropanes;
monochlorobenzenes;
tertiary alcohol;
triazoles
4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile[no description available]low00monochlorobenzenes;
nitrile;
triazoles
metconazole[no description available]low00conazole fungicide;
cyclopentanols;
monochlorobenzenes;
tertiary alcohol;
triazole fungicide;
triazoles		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
cloransulam-methyl[no description available]low00methyl ester;
monochlorobenzenes;
organofluorine compound;
sulfonamide;
triazolopyrimidines		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
2-amino-5-chlorophenol[no description available]low00monochlorobenzenes;
phenols;
primary amino compound
pencycuron[no description available]low00monochlorobenzenes;
phenylureas		antifungal agrochemical
fluazinam[no description available]low00(trifluoromethyl)benzenes;
aminopyridine;
C-nitro compound;
chloropyridine;
monochlorobenzenes;
secondary amino compound		allergen;
antifungal agrochemical;
apoptosis inducer;
environmental contaminant;
xenobiotic
flufenoxuron[no description available]low00(trifluoromethyl)benzenes;
benzoylurea insecticide;
difluorobenzene;
monochlorobenzenes;
monofluorobenzenes		mite growth regulator
chlorfenapyr[no description available]low00hemiaminal ether;
monochlorobenzenes;
nitrile;
organochlorine acaricide;
organochlorine insecticide;
organofluorine acaricide;
organofluorine insecticide;
pyrroles		proacaricide;
proinsecticide
aclonifen[no description available]low00aromatic ether;
C-nitro compound;
monochlorobenzenes;
primary amino compound;
substituted aniline		agrochemical;
carotenoid biosynthesis inhibitor;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
pyraclofos[no description available]low00monochlorobenzenes;
organic thiophosphate;
organochlorine insecticide;
organosulfur compound;
organothiophosphate insecticide;
pyrazoles		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
novaluron[no description available]low00aromatic ether;
benzoylurea insecticide;
monochlorobenzenes;
organofluorine compound
sr141716[no description available]low00amidopiperidine;
carbohydrazide;
dichlorobenzene;
monochlorobenzenes;
pyrazoles		anti-obesity agent;
appetite depressant;
CB1 receptor antagonist
3-chloro-L-tyrosine[no description available]low00chloroamino acid;
L-alpha-amino acid zwitterion;
L-tyrosine derivative;
monochlorobenzenes;
non-proteinogenic L-alpha-amino acid		biomarker;
human metabolite
rh-0345[no description available]low00bisacylhydrazine insecticide;
monochlorobenzenes
3-chloro-4-hydroxyphenylacetic acid[no description available]low00hydroxy monocarboxylic acid;
monochlorobenzenes;
phenols		mammalian metabolite
mosapride[no description available]low00aromatic ether;
benzamides;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
secondary carboxamide;
substituted aniline;
tertiary amino compound
gefitinib[no description available]low00aromatic ether;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
quinazolines;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
epidermal growth factor receptor antagonist
vatalanib[no description available]low00monochlorobenzenes;
phthalazines;
pyridines;
secondary amino compound		angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
vascular endothelial growth factor receptor antagonist
carpropamid[no description available]low00amide fungicide;
cyclopropylcarboxamide;
monochlorobenzenes		antifungal agrochemical;
EC 4.2.1.94 (scytalone dehydratase) inhibitor;
melanin synthesis inhibitor;
xenobiotic
canertinib[no description available]low00monochlorobenzenes;
morpholines;
organofluorine compound;
quinazolines		antineoplastic agent;
tyrosine kinase inhibitor
s 23121[no description available]low00aromatic ether;
dicarboximide;
monochlorobenzenes;
monofluorobenzenes;
pyrroline;
terminal acetylenic compound
tipifarnib[no description available]low00imidazoles;
monochlorobenzenes;
primary amino compound;
quinolone		antineoplastic agent;
apoptosis inducer;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor
4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1h-pyrrole-3-carbonitrile[no description available]low00monochlorobenzenes;
nitrile;
organobromine compound;
organochlorine acaricide;
organochlorine insecticide;
organofluorine acaricide;
organofluorine insecticide;
pyrroles		acaricide;
antifouling biocide;
insecticide
2-chloro-n-(4-chlorobiphenyl-2-yl)nicotinamide[no description available]low00anilide fungicide;
biphenyls;
monochlorobenzenes;
pyridinecarboxamide		antifungal agrochemical;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
environmental contaminant;
xenobiotic
sorafenib[no description available]low00(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
phenylureas;
pyridinecarboxamide		angiogenesis inhibitor;
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
ferroptosis inducer;
tyrosine kinase inhibitor
dabuzalgron[no description available]low00aromatic ether;
imidazoles;
monochlorobenzenes;
sulfonamide		alpha-adrenergic agonist
l 778,123[no description available]low00imidazoles;
monochlorobenzenes;
nitrile;
piperazinone;
tertiary amino compound		antineoplastic agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor
1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea[no description available]low00monochlorobenzenes;
phenylureas;
pyrazoles		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine[no description available]low006-aminopurines;
acetylenic compound;
methoxybenzenes;
monochlorobenzenes;
organofluorine compound		antineoplastic agent;
Hsp90 inhibitor
4-chlorocinnamic acid[no description available]low00monochlorobenzenes
oncrasin-1[no description available]low00arenecarbaldehyde;
indoles;
monochlorobenzenes		antineoplastic agent;
apoptosis inducer
6-amino-1-(4-chlorophenyl)-2-oxo-4-(1,2,4-triazol-1-ylmethyl)-5-pyrimidinecarbonitrile[no description available]low00monochlorobenzenes;
nitrile;
pyrimidone;
triazoles
N-[(4-chlorophenyl)methyl]-2-(2,4-dioxo-1H-pyrimidin-6-yl)acetamide[no description available]low00monochlorobenzenes;
pyrimidone;
secondary carboxamide
capsazepine[no description available]low00benzazepine;
catechols;
monochlorobenzenes;
thioureas		capsaicin receptor antagonist
1-(4-chlorophenyl)-3-[4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl]urea[no description available]low001,3-thiazoles;
monochlorobenzenes;
phenylureas;
thiophenes
n-(3-chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide[no description available]low00anilide fungicide;
monocarboxylic acid amide;
monochlorobenzenes;
organosulfur compound;
thiadiazoles		antifungal agrochemical
ethyl 1-[4-(4-chlorobenzenesulfonamido)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate[no description available]low00ethyl ester;
monochlorobenzenes;
organofluorine compound;
pyrazoles;
sulfonamide
sr 144528[no description available]low00bridged compound;
monochlorobenzenes;
pyrazoles;
secondary carboxamide		CB2 receptor antagonist;
EC 2.3.1.26 (sterol O-acyltransferase) inhibitor
4-chlorobenzoyl coenzyme a[no description available]low00chlorobenzoyl-CoA;
monochlorobenzenes
epoxiconazole[no description available]low00epoxide;
monochlorobenzenes;
monofluorobenzenes;
triazoles
l 663536[no description available]low00aryl sulfide;
indoles;
monocarboxylic acid;
monochlorobenzenes		antineoplastic agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
leukotriene antagonist
brl 15572[no description available]low00monochlorobenzenes;
N-alkylpiperazine;
N-arylpiperazine;
secondary alcohol		geroprotector;
serotonergic antagonist
ML162[no description available]low00monochlorobenzenes;
monomethoxybenzene;
organochlorine compound;
secondary carboxamide;
tertiary carboxamide;
thiophenes		EC 1.11.1.9 (glutathione peroxidase) inhibitor;
ferroptosis inducer
1-[4-(2-chlorophenoxy)butyl]imidazole[no description available]low00aromatic ether;
imidazoles;
monochlorobenzenes
clopidogrel carboxylic acid[no description available]low00monocarboxylic acid;
monochlorobenzenes;
tertiary amino compound;
thienopyridine		drug metabolite;
marine xenobiotic metabolite
sb 415286[no description available]low00C-nitro compound;
maleimides;
monochlorobenzenes;
phenols;
secondary amino compound;
substituted aniline		antioxidant;
apoptosis inducer;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
neuroprotective agent
sc 560[no description available]low00aromatic ether;
monochlorobenzenes;
organofluorine compound;
pyrazoles		angiogenesis modulating agent;
antineoplastic agent;
apoptosis inducer;
cyclooxygenase 1 inhibitor;
non-steroidal anti-inflammatory drug
ver-49009[no description available]low00aromatic amide;
monochlorobenzenes;
monomethoxybenzene;
pyrazoles;
resorcinols		Hsp90 inhibitor
jtk-303[no description available]low00aromatic ether;
monochlorobenzenes;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone		HIV-1 integrase inhibitor
alvocidib[no description available]low00dihydroxyflavone;
hydroxypiperidine;
monochlorobenzenes;
tertiary amino compound		antineoplastic agent;
antirheumatic drug;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
kn 93[no description available]low00monochlorobenzenes;
monomethoxybenzene;
primary alcohol;
sulfonamide;
tertiary amino compound		EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor;
geroprotector
8-(3-chlorostyryl)caffeine[no description available]low00monochlorobenzenes;
trimethylxanthine		adenosine A2A receptor antagonist;
EC 1.4.3.4 (monoamine oxidase) inhibitor
4-chlorochalcone[no description available]low00chalcones;
monochlorobenzenes
dimethomorph[no description available]low00aromatic ether;
enamide;
monochlorobenzenes;
morpholine fungicide;
tertiary carboxamide
cinidon-ethyl[no description available]low00ethyl ester;
isoindoles;
monochlorobenzenes		herbicide
proguanil[no description available]low00biguanides;
monochlorobenzenes		antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
monorden[no description available]low00cyclic ketone;
enone;
epoxide;
macrolide antibiotic;
monochlorobenzenes;
phenols		antifungal agent;
metabolite;
tyrosine kinase inhibitor
clovoxamine[no description available]low005-methoxyvalerophenone O-(2-aminoethyl)oxime;
monochlorobenzenes		antidepressant
pyrachlostrobin[no description available]low00aromatic ether;
carbamate ester;
carbanilate fungicide;
methoxycarbanilate strobilurin antifungal agent;
monochlorobenzenes;
pyrazoles		antifungal agrochemical;
environmental contaminant;
mitochondrial cytochrome-bc1 complex inhibitor;
xenobiotic
ascofuranone[no description available]low00dihydroxybenzaldehyde;
meroterpenoid;
monochlorobenzenes;
olefinic compound;
resorcinols;
sesquiterpenoid;
tetrahydrofuranone		angiogenesis inhibitor;
antilipemic drug;
antineoplastic agent;
antiprotozoal drug;
fungal metabolite
uniconazole[no description available]low00monochlorobenzenes;
secondary alcohol;
triazoles
lumefantrine[no description available]low00fluorenes;
monochlorobenzenes;
secondary alcohol;
tertiary amine		antimalarial
strobilurin b[no description available]low00enoate ester;
enol ether;
methoxyacrylate strobilurin antifungal agent;
monochlorobenzenes;
monomethoxybenzene		antifungal agent;
fungal metabolite;
mitochondrial cytochrome-bc1 complex inhibitor
ekb 569[no description available]low00aminoquinoline;
monocarboxylic acid amide;
monochlorobenzenes;
nitrile		protein kinase inhibitor
prothioconazole[no description available]low00cyclopropanes;
monochlorobenzenes;
tertiary alcohol;
thiocarbonyl compound;
triazoles
aminopurvalanol a[no description available]low00monochlorobenzenes;
purvalanol		protein kinase inhibitor
n-demethylloperamide[no description available]low00monocarboxylic acid amide;
monochlorobenzenes;
piperidines;
tertiary alcohol		drug metabolite
lenvatinib[no description available]low00aromatic amide;
aromatic ether;
cyclopropanes;
monocarboxylic acid amide;
monochlorobenzenes;
phenylureas;
quinolines		antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
fibroblast growth factor receptor antagonist;
orphan drug;
vascular endothelial growth factor receptor antagonist
sd 0006[no description available]low00monochlorobenzenes;
N-acylpiperidine;
primary alcohol;
pyrazoles;
pyrimidines
dapagliflozin[no description available]low00aromatic ether;
C-glycosyl compound;
monochlorobenzenes		hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
solabegron[no description available]low00carboxybiphenyl;
monochlorobenzenes;
secondary alcohol;
secondary amino compound;
substituted aniline		beta-adrenergic agonist
azd 6244[no description available]low00benzimidazoles;
bromobenzenes;
hydroxamic acid ester;
monochlorobenzenes;
organofluorine compound;
secondary amino compound		anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
bibw 2992[no description available]low00aromatic ether;
enamide;
furans;
monochlorobenzenes;
organofluorine compound;
quinazolines;
secondary carboxamide;
tertiary amino compound		antineoplastic agent;
tyrosine kinase inhibitor
ki16425[no description available]low00carbamate ester;
isoxazoles;
monocarboxylic acid;
monochlorobenzenes;
organic sulfide
fluoxastrobin[no description available]low00aromatic ether;
dioxazine;
monochlorobenzenes;
organofluorine compound;
oxime O-ether;
pyrimidines;
strobilurin antifungal agent		antifungal agrochemical;
mitochondrial cytochrome-bc1 complex inhibitor
regorafenib[no description available]low00(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
monofluorobenzenes;
phenylureas;
pyridinecarboxamide		antineoplastic agent;
hepatotoxic agent;
tyrosine kinase inhibitor
at 7867[no description available]low00monochlorobenzenes;
piperidines;
pyrazoles		antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
erastin[no description available]low00aromatic ether;
diether;
monochlorobenzenes;
N-acylpiperazine;
N-alkylpiperazine;
quinazolines;
tertiary carboxamide		antineoplastic agent;
ferroptosis inducer;
voltage-dependent anion channel inhibitor
abt-737[no description available]low00aromatic amine;
aryl sulfide;
biphenyls;
C-nitro compound;
monochlorobenzenes;
N-arylpiperazine;
N-sulfonylcarboxamide;
secondary amino compound;
tertiary amino compound		anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor
benzobicyclon[no description available]low00aromatic ketone;
carbobicyclic compound;
cyclic ketone;
monochlorobenzenes;
organic sulfide;
sulfone
ascochlorin[no description available]low00cyclohexanones;
dihydroxybenzaldehyde;
meroterpenoid;
monochlorobenzenes;
olefinic compound;
resorcinols;
sesquiterpenoid		angiogenesis inhibitor;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
fungal metabolite
chlorantranilipole[no description available]low00monochlorobenzenes;
organobromine compound;
pyrazole insecticide;
pyrazoles;
pyridines;
secondary carboxamide		ryanodine receptor agonist
mandipropamid[no description available]low00aromatic ether;
monocarboxylic acid amide;
monochlorobenzenes;
terminal acetylenic compound
azd 8931[no description available]low00aromatic ether;
monochlorobenzenes;
monofluorobenzenes;
piperidines;
quinazolines;
secondary amino compound;
tertiary amino compound		EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
epidermal growth factor receptor antagonist
pf 00299804[no description available]low00enamide;
monochlorobenzenes;
monofluorobenzenes;
piperidines;
quinazolines;
secondary amino compound;
secondary carboxamide;
tertiary amino compound		antineoplastic agent;
epidermal growth factor receptor antagonist
MI-63[no description available]low00azaspiro compound;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
oxindoles;
pyrrolidines;
secondary carboxamide		apoptosis inducer
tembotrione[no description available]low00aromatic ketone;
beta-triketone;
cyclic ketone;
ether;
monochlorobenzenes;
organofluorine compound;
sulfone		agrochemical;
carotenoid biosynthesis inhibitor;
EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor;
herbicide
pd 0348292[no description available]low00monochlorobenzenes;
monofluorobenzenes;
pyridone;
pyrrolidines;
secondary carboxamide;
ureas		anticoagulant;
EC 3.4.21.6 (coagulation factor Xa) inhibitor;
serine protease inhibitor
butafenacil[no description available]low00benzoate ester;
diester;
monochlorobenzenes;
olefinic compound;
organofluorine compound		EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
empagliflozin[no description available]low00aromatic ether;
C-glycosyl compound;
monochlorobenzenes;
tetrahydrofuryl ether		hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
methampicillin[no description available]low00monochlorobenzenes;
tertiary alcohol;
triazoles		brassinosteroid biosynthesis inhibitor
dafadine B[no description available]low00aromatic amide;
aromatic ether;
isoxazoles;
monochlorobenzenes;
monofluorobenzenes;
N-acylpiperidine;
pyridines		P450 inhibitor
azd 7545[no description available]low00benzamides;
monochlorobenzenes;
organofluorine compound;
secondary carboxamide;
sulfone;
tertiary alcohol;
tertiary carboxamide		EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor;
hypoglycemic agent
gdc 0449[no description available]low00benzamides;
monochlorobenzenes;
pyridines;
sulfone		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist;
teratogenic agent
navitoclax[no description available]low00aryl sulfide;
monochlorobenzenes;
morpholines;
N-sulfonylcarboxamide;
organofluorine compound;
piperazines;
secondary amino compound;
sulfone;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor
cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl]hydrazone[no description available]low001,3-thiazoles;
hydrazone;
monochlorobenzenes		EC 2.3.1.48 (histone acetyltransferase) inhibitor
plx4032[no description available]low00aromatic ketone;
difluorobenzene;
monochlorobenzenes;
pyrrolopyridine;
sulfonamide		antineoplastic agent;
B-Raf inhibitor
ulixacaltamide[no description available]low00benzamides;
monochlorobenzenes;
monofluorobenzenes;
piperidines;
secondary carboxamide		non-narcotic analgesic;
T-type calcium channel blocker
fluazaindolizine[no description available]low00aromatic amide;
imidazopyridine;
monocarboxylic acid amide;
monochlorobenzenes;
monomethoxybenzene;
N-sulfonylcarboxamide;
organofluorine pesticide		agrochemical;
nematicide
ML-210[no description available]low00C-nitro compound;
diarylmethane;
isoxazoles;
monochlorobenzenes;
N-acylpiperazine;
N-alkylpiperazine;
tertiary carboxamide		antineoplastic agent;
EC 1.11.1.9 (glutathione peroxidase) inhibitor;
ferroptosis inducer;
prodrug
abt-199[no description available]low00aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-alkylpiperazine;
N-arylpiperazine;
N-sulfonylcarboxamide;
oxanes;
pyrrolopyridine		antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor
pf 4800567[no description available]low00aromatic ether;
monochlorobenzenes;
oxanes;
pyrazolopyrimidine		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
pelabresib[no description available]low00monochlorobenzenes;
organic heterotricyclic compound;
primary carboxamide		antineoplastic agent;
bromodomain-containing protein 4 inhibitor
MS-417[no description available]low00methyl ester;
monochlorobenzenes;
thienotriazolodiazepine
2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol[no description available]low00(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
tertiary alcohol;
triazoles
ivosidenib[no description available]low00cyanopyridine;
monochlorobenzenes;
organofluorine compound;
pyrrolidin-2-ones;
secondary carboxamide;
tertiary carboxamide		antineoplastic agent;
EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor
2-(5'-chloro-2'-phosphoryloxyphenyl)-6-chloro-4-(3h)-quinazolinone[no description available]low00aryl phosphate;
monochlorobenzenes;
quinazolines		fluorochrome
liproxstatin-1[no description available]low00azaspiro compound;
monochlorobenzenes;
organic heterotricyclic compound;
secondary amino compound		antioxidant;
cardioprotective agent;
ferroptosis inhibitor;
radical scavenger
ConditionIndicatedRelationship StrengthStudiesTrials
Anemia, Fanconi0low10
Body Weight0low10
Encephalitis, Polio0low10
Epidemic Acute Poliomyelitis0low10
Fanconi Anemia0low10
Fanconi Hypoplastic Anemia0low10
Fanconi Pancytopenia0low10
Fanconi Panmyelopathy0low10
Fanconi's Anemia0low10
Infantile Paralysis0low10
Malaria, Falciparum0low10
Plasmodium falciparum Malaria0low10
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10
Pregnancy0low10

Research Highlights

Bioavailability (2)

ArticleYear
The effect of chlorine substitution on the disposition of polychlorinated biphenyls following dermal administration.
Toxicology and applied pharmacology, Oct-01, Volume: 216, Issue: 1		2006
Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4'-dichlorobiphenyl, phenobarbitone and pregnenolone-16-alpha-carbonitrile.
The Journal of pharmacy and pharmacology, Volume: 41, Issue: 5		1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
Influence of symmetrical polychlorinated biphenyl isomers on embryo and fetal development in mice. II. Comparison of 4,4'-dichlorobiphenyl, 3,3',4,4'-tetrachlorobiphenyl, 3,3',5,5'-tetrachlorobiphenyl, and 3,3',4,4'-tetramethylbiphenyl.
Fundamental and applied toxicology : official journal of the Society of Toxicology, Volume: 13, Issue: 4		1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]