Page last updated: 2024-12-06

2,4,5,2',5'-pentachlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2,4,5,2',5'-pentachlorobiphenyl is a polychlorinated biphenyl (PCB) congener, specifically a highly chlorinated PCB. It has been found to be a persistent organic pollutant, meaning it is resistant to breakdown in the environment. It has been detected in various environmental matrices like soil, water, and air. It is known for its toxic effects, including endocrine disruption and potential carcinogenic activity. Its presence in the environment is of concern due to its persistence and bioaccumulation in food chains. Studies on 2,4,5,2',5'-pentachlorobiphenyl aim to understand its environmental fate, its toxicological effects, and its potential risks to human health. Research on 2,4,5,2',5'-pentachlorobiphenyl is important for developing strategies to mitigate its environmental impact and to protect human health.'

Cross-References

ID SourceID
PubMed CID37807
CHEMBL ID14041
SCHEMBL ID811509
MeSH IDM0054882

Synonyms (29)

Synonym
1,1'-biphenyl, 2,2',4,5,5'-pentachloro-
2,2',4,5,5'-pentachlorobiphenyl
inchi=1/c12h5cl5/c13-6-1-2-9(14)7(3-6)8-4-11(16)12(17)5-10(8)15/h1-5
37680-73-2
pcb 101
2,2',4,5,5'pentachlorobiphenyl
2,4,5,2',5'-pentachlorobiphenyl
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene
CHEMBL14041
2,4,5,2',5'-pentachloro-biphenyl
unii-803yvi5bnp
803yvi5bnp ,
pcb no 101
AKOS015903436
SCHEMBL811509
pcb-101
LAHWLEDBADHJGA-UHFFFAOYSA-N
2,2',4,5,5'-pentachloro-1,1'-biphenyl
DTXSID8038304 ,
pcb no 101, analytical standard
pcb no. 101 10 microg/ml in isooctane
pcb no. 101
pcb no. 101 100 microg/ml in ihexane
pcb no. 101 100 microg/ml in isooctane
k 101
cb 101; pcb 101
Q27269110
PD162576
dtxcid6018304

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"Several studies indicate that in utero and perinatal exposure to polychlorinated biphenyls (PCBs) induces adverse reproductive effects, but it remains unclear whether such effects may be transmitted to subsequent generations."( Effects of polychlorinated biphenyls in CD-1 mice: reproductive toxicity and intergenerational transmission.
Berrini, A; Borromeo, V; Fiandanese, N; Fischer, B; Pocar, P; Rhind, SM; Schaedlich, K; Schmidt, JS; Secchi, C; Zhang, Z, 2012
)
0.38

Dosage Studied

ExcerptRelevanceReference
" Both species were dosed orally and kept in metabolism cages for 5 days."( 2,2',4,5,5'-Pentachlorobiphenyl: comparative metabolism in mink (Mustela vison) and mouse.
Hovander, L; Lund, BO; Wehler, EK, 1996
)
0.29
" The results showed that higher Pd loading, higher dosage of Pd/Fe, lower initial concentration of 2,2',4,5,5'-pentachlorobiphenyl and slightly acid condition were beneficial to the catalytic dechlorination of 2,2',4,5,5'-pentachlorobiphenyl."( Catalytic dechlorination of polychlorinated biphenyls in soil by palladium-iron bimetallic catalyst.
Fan, S; He, N; Li, P; Ren, W; Verkhozina, VA; Zhou, Y, 2009
)
0.35
" The results showed that higher Pd loading, higher dosage of Pd/Fe and slightly acid condition were beneficial to the catalytic dechlorination of 2,2('),4,5,5(')-pentachlorobiphenyl."( Degradation of pentachlorobiphenyl by a sequential treatment using Pd coated iron and an aerobic bacterium (H1).
Fan, S; He, N; Li, P; Ren, W; Zhou, Y, 2009
)
0.35
" In this study, the contamination history and recovery of a watercourse heavily loaded by the chemical wood industry were studied by analyzing PCDDs, PCDFs and PCBs from vertical sediment samples and by measuring hepatic EROD activity from rainbow trout intraperitoneally dosed with the sediment extracts."( Vertical distribution of AhR-activating compounds in sediments contaminated by modernized pulp and paper industry.
Oikari, A; Ratia, H, 2014
)
0.4
"Hormesis, a biphasic dose-response phenomenon, which is characterized by stimulation of an end point at a low-dose and inhibition at a high-dose."( Hormetic effects of noncoplanar PCB exposed to human lung fibroblast cells (HELF) and possible role of oxidative stress.
Abbas, G; Hashmi, MZ; Hu, J; Khan, KY; Shen, C; Su, X; Yu, C, 2015
)
0.42
" In summary, this study provides dose-response linkages between effects of lower chlorinated PCBs and their concentrations in human plasma."( Telomerase gene expression bioassays indicate metabolic activation of genotoxic lower chlorinated polychlorinated biphenyls.
Gostek, S; Hoffmann, J; Kraus, T; Preisinger, C; Quinete, N; Schettgen, T; Vasko, T; Ziegler, P, 2018
)
0.48
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID23673Partition coefficient (logP)2002Bioorganic & medicinal chemistry letters, Apr-08, Volume: 12, Issue:7
Novel estimation of lipophilic behaviour of polychlorinated biphenyls.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (49)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (2.04)18.7374
1990's3 (6.12)18.2507
2000's17 (34.69)29.6817
2010's24 (48.98)24.3611
2020's4 (8.16)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.00 (24.57)
Research Supply Index3.91 (2.92)
Research Growth Index5.35 (4.65)
Search Engine Demand Index17.79 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (2.04%)4.05%
Observational0 (0.00%)0.25%
Other48 (97.96%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]