2,2',5-trichlorobiphenyl (PCB 28) is a highly persistent and bioaccumulative environmental contaminant, classified as a probable human carcinogen by the International Agency for Research on Cancer (IARC). It has been widely used in industrial applications, including electrical equipment, hydraulic fluids, and plasticizers. PCB 28 can enter the environment through spills, leaks, and improper disposal. It can accumulate in the food chain, posing a risk to human health and wildlife. The compound is particularly concerning due to its persistence in the environment and its potential to disrupt endocrine function, leading to reproductive and developmental effects. Research on PCB 28 focuses on understanding its fate and transport in the environment, its impact on human and wildlife health, and the development of effective remediation strategies.'
| ID Source | ID |
|---|---|
| PubMed CID | 37803 |
| CHEMBL ID | 13843 |
| SCHEMBL ID | 381603 |
| MeSH ID | M0210269 |
| Synonym |
|---|
| 2,2',5-trichlorobiphenyl |
| 1,1'-biphenyl, 2,2',5-trichloro- |
| pcb 18 |
| 2,5,2'-trichlorobiphenyl |
| brn 2453347 |
| inchi=1/c12h7cl3/c13-8-5-6-12(15)10(7-8)9-3-1-2-4-11(9)14/h1-7h |
| dcmurxaztzqafb-uhfffaoysa- |
| 1,4-dichloro-2-(2-chlorophenyl)benzene |
| CHEMBL13843 |
| 2,5,2'-trichloro-biphenyl |
| 6lev53y3ox , |
| unii-6lev53y3ox |
| 37680-65-2 |
| pcb no 18 |
| AKOS015903401 |
| SCHEMBL381603 |
| 2,2',5-tbp |
| 2,2',5-trichloro-1,1'-biphenyl # |
| 2,2',5'-trichlorobiphenyl |
| DCMURXAZTZQAFB-UHFFFAOYSA-N |
| 2,2',5-trichloro-1,1'-biphenyl |
| DTXSID6073491 , |
| pcb no 18, analytical standard |
| pcb no. 18 10 microg/ml in isooctane |
| pcb no. 18 |
| 2,2',5-trichlorobiphenyl, 99%, bz# 18, vial of 250 mg |
| 2,2',5-trichlorbiphenyl |
| Q27265105 |
| dtxcid7039383 |
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adult female houseflies (Musca domestica) were topically dosed with 10, 15, and 20 micrograms of 2,2',5-trichlorobiphenyl (PCB-18) in acetone at 1, 5, and 15 days following emergence." | ( Influence of enzyme levels on the toxicity and in vitro metabolism of 2,2',5-trichlorobiphenyl in houseflies. Hansen, LG; Saghir, SA, 1994) | 0.74 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID23673 | Partition coefficient (logP) | 2002 | Bioorganic & medicinal chemistry letters, Apr-08, Volume: 12, Issue:7 | Novel estimation of lipophilic behaviour of polychlorinated biphenyls. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.26) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||