2,3,5,6-tetrachlorobiphenyl profile

2,3,5,6-tetrachlorobiphenyl (PCB 138) is a highly chlorinated polychlorinated biphenyl (PCB) congener that has been extensively studied due to its environmental persistence, bioaccumulation, and potential toxicity. It is synthesized via the chlorination of biphenyl, a process that can produce a wide range of congeners with varying degrees of chlorination. 2,3,5,6-tetrachlorobiphenyl has been detected in various environmental compartments, including soil, water, and air, and can bioaccumulate in organisms, particularly in fatty tissues. It is known to have adverse effects on human health, including endocrine disruption, developmental neurotoxicity, and potential carcinogenic effects. The study of 2,3,5,6-tetrachlorobiphenyl and other PCBs is crucial for understanding their environmental fate, human health risks, and for developing effective strategies for their mitigation.'
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2,3,5,6-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which one of the phenyl groups is substituted by chlorines at positions 2, 3, 5, and 6. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	36402
CHEBI ID	34224
SCHEMBL ID	2936378
MeSH ID	M0209515

Synonym
CHEBI:34224 ,
2,3,5,6-tetrachloro-1,1'-biphenyl
1,1'-biphenyl, 2,3,5,6-tetrachloro-
inchi=1/c12h6cl4/c13-8-6-9(14)12(16)10(11(8)15)7-4-2-1-3-5-7/h1-6
2,3,5,6-tetrachlorobiphenyl
33284-54-7
pcb 65
1,2,4,5-tetrachloro-3-phenylbenzene
f7xe9g6462 ,
unii-f7xe9g6462
biphenyl, 2,3,5,6-tetrachloro-
SCHEMBL2936378
BLAYIQLVUNIICD-UHFFFAOYSA-N
DTXSID0074136 ,
1,1'-biphenyl, 2,3,5,6-tetrachloro-; biphenyl, 2,3,5,6-tetrachloro- (7ci,8ci); 2,3,5,6-tetrachloro-1,1'-biphenyl; 2,3,5,6-tetrachlorobiphenyl; pcb 65; 2,3,5,6-tetracb
pcb no. 65 10 microg/ml in isooctane
Q27115919
2,3,5,6,-tetrachlorobiphenyl
2,3,5,6-tetrachlorbiphenyl
CS-0451175
2,3,5,6-tetracb
dtxcid6038665

Class	Description
tetrachlorobiphenyl	Any polychlorobiphenyl with molecular formula C12H6Cl4.
tetrachlorobenzene	Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	4 (57.14)	18.2507
2000's	2 (28.57)	29.6817
2010's	1 (14.29)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetone methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).	2.06	1	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent
formic acid formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.	2	1	monocarboxylic acid	antibacterial agent; astringent; metabolite; protic solvent; solvent
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	2	1	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	2.4	2	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
molybdenum Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.	1.99	1	chromium group element atom	micronutrient
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	2.06	1	copper group element atom; elemental silver	Escherichia coli metabolite
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	2.91	4	diatomic chlorine; gas molecular entity	bleaching agent
2,2',6,6'-tetrachlorobiphenyl 2,2',6,6'-tetrachlorobiphenyl: structure in first source	2.06	1
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2	1	benzenes; phenyl acetates
kc 400 KC 400: mixture of polychlorinated biphenyls. 3,3',5,5'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which both phenyl groups are substituted by chlorines at positions 3 and 5.	2.06	1	dichlorobenzene; tetrachlorobiphenyl
sodium molybdate(vi) sodium molybdate(VI): RN given refers to molybdic acid, di-Na salt. sodium molybdate (anhydrous) : An inorganic sodium salt having molybdate as the counterion.	1.99	1	inorganic sodium salt	poison
bes 2-[bis(2-hydroxyethyl)amino]ethanesulfonic acid : A Good's buffer substance, pKa = 7.15 at 20 degreeC.	1.99	1	1,1-diunsubstituted alkanesulfonate; amino sulfonic acid; BES
fumaric acid fumaric acid: see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters. fumaric acid : A butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.	2	1	butenedioic acid	food acidity regulator; fundamental metabolite; geroprotector
sodium acetate, anhydrous Sodium Acetate: The trihydrate sodium salt of acetic acid, which is used as a source of sodium ions in solutions for dialysis and as a systemic and urinary alkalizer, diuretic, and expectorant.	1.99	1	organic sodium salt	NMR chemical shift reference compound
fumarates Fumarates: Compounds based on fumaric acid.. fumarate(2-) : A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2-)	2	1	butenedioate; C4-dicarboxylate	human metabolite; metabolite; Saccharomyces cerevisiae metabolite

2,3,5,6-tetrachlorobiphenyl

Description

Cross-References

Synonyms (22)

Drug Classes (2)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.19

Study Types