2,2',6,6'-tetrachlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,2',6,6'-Tetrachlorobiphenyl (PCB 153) is a persistent organic pollutant (POP) that has been widely used in industrial applications, such as electrical equipment, hydraulic fluids, and plasticizers. It is a highly stable compound that can persist in the environment for decades. PCB 153 is known to bioaccumulate in the food chain, leading to high levels in wildlife and humans. Studies have shown that PCB 153 can have a range of adverse effects on human health, including endocrine disruption, reproductive problems, developmental delays, and cancer. It is also known to be toxic to aquatic organisms and can disrupt ecosystem function. The synthesis of PCB 153 involves the chlorination of biphenyl in the presence of a catalyst. Due to its persistence in the environment and its potential health risks, PCB 153 is a subject of extensive research. Ongoing research aims to understand the fate and transport of PCB 153 in the environment, develop methods for its remediation, and assess its potential health impacts on humans and wildlife. This compound is widely studied due to its environmental persistence, bioaccumulation, and toxic effects on human health and wildlife. Studies investigate its fate and transport, remediation, and health impacts. '

2,2',6,6'-tetrachlorobiphenyl: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	27588
CHEMBL ID	82258
SCHEMBL ID	2471569
MeSH ID	M0303731

Synonyms (28)

Synonym
CHEMBL82258
2,6,2',6'-tetrachloro-biphenyl(26tcb)
2,6,2',6'-tetrachloro-biphenyl
inchi=1/c12h6cl4/c13-7-3-1-4-8(14)11(7)12-9(15)5-2-6-10(12)16/h1-6
15968-05-5
2,6,2',6'-tetrachlorobiphenyl
2,2',6,6'-tetrachloro-1,1'-biphenyl
brn 2054497
2,2',6,6'-tetrachlorobiphenyl
pcb 54
biphenyl, 2,2',6,6'-tetrachloro-
1,1'-biphenyl, 2,2',6,6'-tetrachloro-
1,3-dichloro-2-(2,6-dichlorophenyl)benzene
unii-1150vtx8qq
1150vtx8qq ,
DTXSID0065983 ,
SCHEMBL2471569
PXAGFNRKXSYIHU-UHFFFAOYSA-N
pcb no. 54 10 microg/ml in isooctane
pcb no. 54
2,2,6,6-tetrachlorobiphenyl
Q27251257
2,2',6,6'-tetrachlorbiphenyl
2,2',6,6'-tetracb
CS-0447501
pcb54
dtxcid2035142
2,2',6,6'-tcb

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Transthyretin	Homo sapiens (human)	Concentration	0.1000	0.0100	0.1380	0.6000	AID161428
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (2)

Process	via Protein(s)	Taxonomy
signal transduction	Transthyretin	Homo sapiens (human)
purine nucleobase metabolic process	Transthyretin	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Process	via Protein(s)	Taxonomy
hormone activity	Transthyretin	Homo sapiens (human)
protein binding	Transthyretin	Homo sapiens (human)
identical protein binding	Transthyretin	Homo sapiens (human)
thyroid hormone binding	Transthyretin	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Process	via Protein(s)	Taxonomy
extracellular region	Transthyretin	Homo sapiens (human)
extracellular space	Transthyretin	Homo sapiens (human)
azurophil granule lumen	Transthyretin	Homo sapiens (human)
extracellular exosome	Transthyretin	Homo sapiens (human)
extracellular space	Transthyretin	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID161436	Relative binding affinity was determined for thyroxin binding prealbumin (TBPA) from rat liver with respect to thyroxine (T4) as KA(comp)/KA(T4) using competitive binding experiment; a = no binding	1987	Journal of medicinal chemistry, Jan, Volume: 30, Issue:1	Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts.
AID161432	Thyroxine binding constant on human plasma prealbumin; No binding	1986	Journal of medicinal chemistry, Dec, Volume: 29, Issue:12	A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID161428	Concentration at which 50% total binding against prealbumin protein occurs	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
AID161427	Relative binding affinity to prealbumin was determined from the competition binding assays and is expressed relative to L-T4	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
AID161430	Displacement of [125I]thyroxin from human plasma prealbumin.	1986	Journal of medicinal chemistry, Dec, Volume: 29, Issue:12	A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID210553	Relative binding affinity was determined by using nuclear receptor from rat liver with respect to thyroxine (T4) as KA(comp)/KA(T4) using competitive binding experiment; a = no binding	1987	Journal of medicinal chemistry, Jan, Volume: 30, Issue:1	Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (50.00)	18.7374
1990's	1 (16.67)	18.2507
2000's	1 (16.67)	29.6817
2010's	1 (16.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.44

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.44 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.39 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.44)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetone methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).	2.06	1	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent
thyroxine [no description available]	1.96	1	2-halophenol; amino acid zwitterion; iodophenol; iodothyronine; non-proteinogenic alpha-amino acid; tyrosine derivative	mitogen
thyroxine Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.	2.37	2	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone
triiodothyronine Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.. 3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.	2.37	2	2-halophenol; amino acid zwitterion; iodophenol; iodothyronine	human metabolite; mouse metabolite; thyroid hormone
diphenyl diphenyl: RN given refers to unlabeled cpd; structure	2.66	3	aromatic fungicide; benzenes; biphenyls	antifungal agrochemical; antimicrobial food preservative
2,4,6-triiodophenol [no description available]	2.37	2
2,3,7,8-tetrachlorodibenzodioxine Tetrachlorodibenzodioxin: A mixture of isomers.	1.97	1	polychlorinated dibenzodioxine
3,3',5'-triiodothyronine [no description available]	2.37	2	iodothyronine	human metabolite
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	2.06	1	copper group element atom; elemental silver	Escherichia coli metabolite
3,4,5,3',4',5'-hexachlorobiphenyl [no description available]	2.66	3	hexachlorobiphenyl; trichlorobenzene
kc 400 KC 400: mixture of polychlorinated biphenyls. 3,3',5,5'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which both phenyl groups are substituted by chlorines at positions 3 and 5.	2.68	3	dichlorobenzene; tetrachlorobiphenyl
2,3,5,6-tetrachlorobiphenyl 2,3,5,6-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which one of the phenyl groups is substituted by chlorines at positions 2, 3, 5, and 6.	2.06	1	tetrachlorobenzene; tetrachlorobiphenyl
raloxifene hydrochloride Raloxifene Hydrochloride: A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.. raloxifene hydrochloride : A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride.	2	1	hydrochloride	bone density conservation agent; estrogen antagonist; estrogen receptor modulator
3,3',5,5'-tetrachlorobiphenyl-4,4'-diol 3,3',5,5'-tetrachlorobiphenyl-4,4'-diol : A member of the class of hydroxybiphenyls formed formally by chlorination of biphenyl-4,4'-diol at C-3, -3', -5 and -5'.	2.66	3	dichlorobenzene; hydroxybiphenyls
4-hydroxy-2',4',6'-trichlorobiphenyl 4-hydroxy-2',4',6'-trichlorobiphenyl: do not confuse with the tetrachlorinated compound, also known as 4-OH-TCB (see 4-OH-TCB (tetra))	2.37	2	biphenyls; trichlorobenzene
4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl 4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl: structure in first source	2.37	2	biphenyls; tetrachlorobenzene
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	2.03	1	carbon group element atom; metalloid atom; nonmetal atom
phosphorus Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.	2.03	1	monoatomic phosphorus; nonmetal atom; pnictogen	macronutrient
piperidines Piperidines: A family of hexahydropyridines.	2	1

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