Page last updated: 2024-12-06

2,2',6,6'-tetrachlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,2',6,6'-Tetrachlorobiphenyl (PCB 153) is a persistent organic pollutant (POP) that has been widely used in industrial applications, such as electrical equipment, hydraulic fluids, and plasticizers. It is a highly stable compound that can persist in the environment for decades. PCB 153 is known to bioaccumulate in the food chain, leading to high levels in wildlife and humans. Studies have shown that PCB 153 can have a range of adverse effects on human health, including endocrine disruption, reproductive problems, developmental delays, and cancer. It is also known to be toxic to aquatic organisms and can disrupt ecosystem function. The synthesis of PCB 153 involves the chlorination of biphenyl in the presence of a catalyst. Due to its persistence in the environment and its potential health risks, PCB 153 is a subject of extensive research. Ongoing research aims to understand the fate and transport of PCB 153 in the environment, develop methods for its remediation, and assess its potential health impacts on humans and wildlife. This compound is widely studied due to its environmental persistence, bioaccumulation, and toxic effects on human health and wildlife. Studies investigate its fate and transport, remediation, and health impacts. '

2,2',6,6'-tetrachlorobiphenyl: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID27588
CHEMBL ID82258
SCHEMBL ID2471569
MeSH IDM0303731

Synonyms (28)

Synonym
CHEMBL82258
2,6,2',6'-tetrachloro-biphenyl(26tcb)
2,6,2',6'-tetrachloro-biphenyl
inchi=1/c12h6cl4/c13-7-3-1-4-8(14)11(7)12-9(15)5-2-6-10(12)16/h1-6
15968-05-5
2,6,2',6'-tetrachlorobiphenyl
2,2',6,6'-tetrachloro-1,1'-biphenyl
brn 2054497
2,2',6,6'-tetrachlorobiphenyl
pcb 54
biphenyl, 2,2',6,6'-tetrachloro-
1,1'-biphenyl, 2,2',6,6'-tetrachloro-
1,3-dichloro-2-(2,6-dichlorophenyl)benzene
unii-1150vtx8qq
1150vtx8qq ,
DTXSID0065983 ,
SCHEMBL2471569
PXAGFNRKXSYIHU-UHFFFAOYSA-N
pcb no. 54 10 microg/ml in isooctane
pcb no. 54
2,2,6,6-tetrachlorobiphenyl
Q27251257
2,2',6,6'-tetrachlorbiphenyl
2,2',6,6'-tetracb
CS-0447501
pcb54
dtxcid2035142
2,2',6,6'-tcb
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TransthyretinHomo sapiens (human)Concentration0.10000.01000.13800.6000AID161428
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (2)

Processvia Protein(s)Taxonomy
signal transductionTransthyretinHomo sapiens (human)
purine nucleobase metabolic processTransthyretinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
hormone activityTransthyretinHomo sapiens (human)
protein bindingTransthyretinHomo sapiens (human)
identical protein bindingTransthyretinHomo sapiens (human)
thyroid hormone bindingTransthyretinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
extracellular regionTransthyretinHomo sapiens (human)
extracellular spaceTransthyretinHomo sapiens (human)
azurophil granule lumenTransthyretinHomo sapiens (human)
extracellular exosomeTransthyretinHomo sapiens (human)
extracellular spaceTransthyretinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID161436Relative binding affinity was determined for thyroxin binding prealbumin (TBPA) from rat liver with respect to thyroxine (T4) as KA(comp)/KA(T4) using competitive binding experiment; a = no binding1987Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts.
AID161432Thyroxine binding constant on human plasma prealbumin; No binding1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID161428Concentration at which 50% total binding against prealbumin protein occurs1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
AID161427Relative binding affinity to prealbumin was determined from the competition binding assays and is expressed relative to L-T41986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
AID161430Displacement of [125I]thyroxin from human plasma prealbumin.1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID210553Relative binding affinity was determined by using nuclear receptor from rat liver with respect to thyroxine (T4) as KA(comp)/KA(T4) using competitive binding experiment; a = no binding1987Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (50.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.44

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.44 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.44)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]