2,2',6,6'-tetrachlorobiphenyl: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 27588 |
| CHEMBL ID | 82258 |
| SCHEMBL ID | 2471569 |
| MeSH ID | M0303731 |
| Synonym |
|---|
| CHEMBL82258 |
| 2,6,2',6'-tetrachloro-biphenyl(26tcb) |
| 2,6,2',6'-tetrachloro-biphenyl |
| inchi=1/c12h6cl4/c13-7-3-1-4-8(14)11(7)12-9(15)5-2-6-10(12)16/h1-6 |
| 15968-05-5 |
| 2,6,2',6'-tetrachlorobiphenyl |
| 2,2',6,6'-tetrachloro-1,1'-biphenyl |
| brn 2054497 |
| 2,2',6,6'-tetrachlorobiphenyl |
| pcb 54 |
| biphenyl, 2,2',6,6'-tetrachloro- |
| 1,1'-biphenyl, 2,2',6,6'-tetrachloro- |
| 1,3-dichloro-2-(2,6-dichlorophenyl)benzene |
| unii-1150vtx8qq |
| 1150vtx8qq , |
| DTXSID0065983 , |
| SCHEMBL2471569 |
| PXAGFNRKXSYIHU-UHFFFAOYSA-N |
| pcb no. 54 10 microg/ml in isooctane |
| pcb no. 54 |
| 2,2,6,6-tetrachlorobiphenyl |
| Q27251257 |
| 2,2',6,6'-tetrachlorbiphenyl |
| 2,2',6,6'-tetracb |
| CS-0447501 |
| pcb54 |
| dtxcid2035142 |
| 2,2',6,6'-tcb |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Transthyretin | Homo sapiens (human) | Concentration | 0.1000 | 0.0100 | 0.1380 | 0.6000 | AID161428 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| signal transduction | Transthyretin | Homo sapiens (human) |
| purine nucleobase metabolic process | Transthyretin | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| hormone activity | Transthyretin | Homo sapiens (human) |
| protein binding | Transthyretin | Homo sapiens (human) |
| identical protein binding | Transthyretin | Homo sapiens (human) |
| thyroid hormone binding | Transthyretin | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| extracellular region | Transthyretin | Homo sapiens (human) |
| extracellular space | Transthyretin | Homo sapiens (human) |
| azurophil granule lumen | Transthyretin | Homo sapiens (human) |
| extracellular exosome | Transthyretin | Homo sapiens (human) |
| extracellular space | Transthyretin | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID161436 | Relative binding affinity was determined for thyroxin binding prealbumin (TBPA) from rat liver with respect to thyroxine (T4) as KA(comp)/KA(T4) using competitive binding experiment; a = no binding | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1 | Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts. |
| AID161432 | Thyroxine binding constant on human plasma prealbumin; No binding | 1986 | Journal of medicinal chemistry, Dec, Volume: 29, Issue:12 | A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin. |
| AID161428 | Concentration at which 50% total binding against prealbumin protein occurs | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Structurally specific binding of halogenated biphenyls to thyroxine transport protein. |
| AID161427 | Relative binding affinity to prealbumin was determined from the competition binding assays and is expressed relative to L-T4 | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Structurally specific binding of halogenated biphenyls to thyroxine transport protein. |
| AID161430 | Displacement of [125I]thyroxin from human plasma prealbumin. | 1986 | Journal of medicinal chemistry, Dec, Volume: 29, Issue:12 | A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin. |
| AID210553 | Relative binding affinity was determined by using nuclear receptor from rat liver with respect to thyroxine (T4) as KA(comp)/KA(T4) using competitive binding experiment; a = no binding | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1 | Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Article | Year |
|---|---|
| Effect of nutrient availability on the uptake of PCB congener 2,2',6,6'-tetrachlorobiphenyl by a diatom (Stephanodiscus minutulus) and transfer to a zooplankton (Daphnia pulicaria). Aquatic toxicology (Amsterdam, Netherlands), Jun-05, Volume: 83, Issue: 1 | 2007 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |