1-methylinosine profile

1-methylinosine, also known as m1I, is a naturally occurring modified nucleoside found in various RNA molecules. It is formed by the methylation of the N1 position of inosine. m1I is involved in several cellular processes, including RNA splicing, translation, and tRNA stability. Its presence in mRNA can influence the efficiency of protein synthesis.

The synthesis of 1-methylinosine can be achieved through various methods, including enzymatic methylation using specific methyltransferases or chemical modification of inosine. Research on 1-methylinosine focuses on understanding its role in gene regulation, its potential as a therapeutic target, and its applications in various fields, such as drug discovery and biotechnology.'

1-methylinosine : Inosine carrying a methyl substituent at position 1 on the hypoxanthine ring. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	65095
CHEBI ID	19065
SCHEMBL ID	19359092
MeSH ID	M0059456

Synonym
1-methylinosine
9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methylpurin-6-one
2140-73-0
c6jr3hab96 ,
unii-c6jr3hab96
inosine, 1-methyl-
m(1)i
CHEBI:19065
9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1-methyl-1,9-dihydro-6h-purin-6-one
n1-methylinosine
WJNGQIYEQLPJMN-IOSLPCCCSA-N
SCHEMBL19359092
DTXSID90175670
9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-6,9-dihydro-1h-purin-6-one
1-methyl-inosine
Q27109107
9-((2r,3r,4s,5r)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl)-1-methyl-purin-6-one
CS-0061842
HY-113139
MS-24005
inosine, 1-methyl
A900900
PD102002

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
inosines	Any purine ribonucleoside that is a derivative of inosine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	14 (56.00)	18.7374
1990's	7 (28.00)	18.2507
2000's	2 (8.00)	29.6817
2010's	2 (8.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (8.00%)	6.00%
Case Studies	1 (4.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	22 (88.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.04	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
putrescine [no description available]	3.05	1	alkane-alpha,omega-diamine	antioxidant; fundamental metabolite
spermidine [no description available]	3.05	1	polyazaalkane; triamine	autophagy inducer; fundamental metabolite; geroprotector
spermine [no description available]	3.05	1	polyazaalkane; tetramine	antioxidant; fundamental metabolite; immunosuppressive agent
uridine [no description available]	8.07	5	uridines	drug metabolite; fundamental metabolite; human metabolite
cytidine [no description available]	2.69	3	cytidines	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
pseudouridine [no description available]	9.45	7	pseudouridines	fundamental metabolite
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	7.38	2	elemental platinum; nickel group element atom; platinum group metal atom
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2.04	1	dihydrogen
1-methyladenosine [no description available]	3.36	7	methyladenosine	human metabolite
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	4.78	10	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
1-methylguanine [no description available]	1.96	1	methylguanine
5-methylcytidine [no description available]	2	1	methylcytidine
1-methylguanosine 1-methylguanosine : Guanosine substituted with a methyl group at position N-1.	8.37	7	methylguanosine	metabolite
n-methyladenosine N-methyladenosine: is a inhibitor of cell differentiation. N(6)-methyladenosine : A methyladenosine compound with one methyl group attached to N(6) of the adenine nucleobase.	2	1	methyladenosine
2'-o-methyladenosine cordysinin B : A member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis.	2	1	adenosines; ether	fungal metabolite
n-acetylcytidine N(4)-acetylcytidine : Cytidine in which one of the exocyclic amino hydrogens is substituted by an acetyl group.	1.99	1	acetamides; cytidines; secondary carboxamide	metabolite
2'-o-methylcytidine [no description available]	2	1	methylcytidine
n(6),n(6)-dimethyladenosine N(6),N(6)-dimethyladenosine : A methyladenosine compound with two methyl groups attached to N(6) of the adenine nucleobase.	2	1	hydrocarbyladenosine
anticodon Anticodon: The sequential set of three nucleotides in TRANSFER RNA that interacts with its complement in MESSENGER RNA, the CODON, during translation in the ribosome.	8.5	2
3-methyluridine 3-methyluridine: isolated from normal human urine & is a minor constituent of tRNA form yeast, rat and human liver; structure	2.38	2
guanine [no description available]	1.96	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanosine ribonucleoside : Any nucleoside where the sugar component is D-ribose.	5.21	16	guanosines; purines D-ribonucleoside	fundamental metabolite
inosinic acid Inosine Monophosphate: Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.	1.96	1	inosine phosphate; purine ribonucleoside 5'-monophosphate	Escherichia coli metabolite; human metabolite; mouse metabolite
inosine [no description available]	6.15	25	inosines; purines D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
7-methylguanine 7-methylguanine: RN given refers to unlabeled cpd; structure. 7-methylguanine : A methylguanine that is guanine substituted by a methyl group at position 7. It is a metabolite obtained during the methylation of DNA.. 2-imino-7-methyl-1,2,3,7-tetrahydro-6H-purin-6-one : A 7-methylguanine that is 1,2,3,7-tetrahydro-6H-purin-6-one substituted by an imino group at position 2 and a methyl group at position 7.. 2-amino-7-methyl-7H-purin-6-ol : A 7-methylguanine that is 7H-purine substituted by an amino group at position 2, a methyl group at position 7 and a hydroxy group at position 6.. 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one : A 7-methylguanine that is 1,7-dihydro-6H-purin-6-one substituted by an amino group at position 2 and a methyl group at position 7.	1.96	1	7-methylguanine
2'-o-methylguanosine 2'-O-methylguanosine : Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.	2.38	2	methylguanosine	metabolite
7-methylguanosine 7-methylguanosine : A positively charged methylguanosine in which a single methyl substituent is located at position 7.	2.65	3	methylguanosine; organic cation	metabolite
8-methylguanosine 8-methylguanosine: structure in first source	1.96	1
n(2),n(2)-dimethylguanosine N(2),N(2)-dimethylguanosine: elevated levels in urine of cancer patients. N(2),N(2)-dimethylguanosine : A guanosine where the hydrogens of the amine group at C-2 are substituted by methyl groups.	3.58	9	methylguanosine	human metabolite

Condition	Relationship Strength	Studies
Asphyxia Neonatorum Respiratory failure in the newborn. (Dorland, 27th ed)	1.96	1
Fetal Growth Restriction [description not available]	1.96	1
Fetal Growth Retardation Failure of a FETUS to attain expected GROWTH.	1.96	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.96	1
Leukemia, Lymphocytic [description not available]	2.36	2
Acute Myelogenous Leukemia [description not available]	1.96	1
Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.	2.36	2
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	1.96	1
Granulocytic Leukemia [description not available]	1.96	1
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	1.96	1
Leukemia, Myeloid Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.	1.96	1
Pneumonia Infection of the lung often accompanied by inflammation.	1.96	1
Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	1.96	1
Anorexia Nervosa An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)	1.96	1
Breast Cancer [description not available]	3.79	4
Lymph Node Metastasis [description not available]	1.95	1
Metastase [description not available]	2.36	2
Breast Neoplasms Tumors or cancer of the human BREAST.	3.79	4
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.36	2
Benign Neoplasms [description not available]	1.98	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	1.98	1
Rheumatoid Arthritis [description not available]	1.99	1
Arthritis, Rheumatoid A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	1.99	1
Idiopathic Inflammatory Myopathies [description not available]	2	1
Myositis Inflammation of a muscle or muscle tissue.	7	1
Breast Diseases Pathological processes of the BREAST.	1.95	1
Adenosis of Breast [description not available]	1.95	1
Fibrocystic Breast Disease A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.	1.95	1
Granulocytic Leukemia, Chronic [description not available]	1.97	1
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.	1.97	1
Bladder Cancer [description not available]	1.96	1
Adenocarcinoma Of Kidney [description not available]	1.96	1
Female Genital Neoplasms [description not available]	1.96	1
Cancer of Kidney [description not available]	1.96	1
Genito-urinary Cancer [description not available]	1.96	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	1.96	1
Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	1.96	1
Genital Neoplasms, Female Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).	1.96	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	1.96	1
Urogenital Neoplasms Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.	1.96	1

1-methylinosine

Description

Cross-References

Synonyms (23)

Roles (1)

Drug Classes (1)

Research

Studies (25)

Market Indicators

Research Demand Index: 18.65

Study Types