| Assay ID | Title | Year | Journal | Article |
|---|
| AID142216 | Binding activity to muscarinic acetylcholine receptor in rat heart, assayed using [3H]QNB as a radioligand in the presence of Gpp(NH)p. | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5). |
| AID142224 | Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]QNB radioligand (in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Cholinergic activity of acetylenic imidazoles and related compounds. |
| AID75763 | Equilibrium dissociation constant of the compound-receptor complex was determined by its ability to antagonize carbachol-induced contractions in the ileum (spasmolytic activity) | 1989 | Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
| Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID101701 | Tested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives. |
| AID116740 | Acute toxicity administered intraperitoneally to mice | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| AID73717 | Concentration that elicits 50% of its own maximum contractile response in guinea pig ileum | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| AID141198 | Relative efficacies determined with oxotremorine as the reference in guinea pig ileum, as a measure of muscarinic acetylcholine receptor M3 agonistic activity | 1992 | Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
| Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID101703 | Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex. | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives. |
| AID75759 | Maximum contractile response relative to that elicited by carbachol in guinea pig ileum | 1989 | Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
| Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID73719 | Concentration that elicits 50% of its own maximum contractile response, in guinea pig ileum | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| Derivatives of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID123417 | Antimuscarinic activity in intact mice was determined as the dose required to double the dose of oxotremorine inducing a predetermined tremor intensity. | 1989 | Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
| Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID141401 | Binding affinity was determined using [3H]-NMS for Muscarinic acetylcholine receptor in SK-N-SH neuroblastoma cells | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides. |
| AID142214 | Binding activity to the muscarinic acetylcholine receptor in rat cortex, assayed using [3H]PZ as a radioligand. | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5). |
| AID142915 | Muscarinic acetylcholine receptor binding affinity was determined using [3H]NMS for NG108-15 neuroblastoma cells | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides. |
| AID142223 | Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]OXO-M radioligand (in vitro) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Cholinergic activity of acetylenic imidazoles and related compounds. |
| AID142231 | Compound was tested for the concentration that inhibited the specific binding of (-)-[3H]-NMS to muscarinic receptor in the rat cerebral cortex. | 1989 | Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
| Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID77637 | Equilibrium dissociation constant muscarinic receptor complex, measured in guinea pig ileum | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| Derivatives of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID228329 | Ratio of Ki value for QNB to that of Ki value for Oxo-M. | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Cholinergic activity of acetylenic imidazoles and related compounds. |
| AID142021 | Binding affinity at muscarinic acetylcholine receptor M4 from NG108-15 cell line in presence of [3H]-NMS | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides. |
| AID113326 | ED50 value as cholinergic agonism by measuring lacrimation in mice (in vivo) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Cholinergic activity of acetylenic imidazoles and related compounds. |
| AID114480 | Central muscarinic activity administered intraperitoneally to mice, expressed as hypothermia | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| AID230678 | Ratio of [3H]QNB+GppNHp/[3H]-QNB | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives. |
| AID142232 | Displacement of [3H]3-quinuclidinyl benzilate ([3H]-QNB) from muscarinic acetylcholine receptor of rat cerebral cortex | 1992 | Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
| Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID142213 | Binding activity to the muscarinic acetylcholine receptor in rat cortex, assayed using [3H]CD as a radioligand. | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5). |
| AID113330 | ED50 value determined as oxotremorine antagonism by measuring salivation in mice (in vivo) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Cholinergic activity of acetylenic imidazoles and related compounds. |
| AID104025 | Binding affinity at [3H]PZ radiolabeled muscarinic M1 receptor in rat cortex. | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives. |
| AID141330 | Percent increase in [3H]myo-inositol at muscarinic acetylcholine receptor M3 from SK-N-SH human neuroblastoma cells | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides. |
| AID114040 | Muscarinic activity administered intraperitoneally to mice, expressed as salivation | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| AID142215 | Binding activity against Muscarinic acetylcholine receptor in rat cortex, using [3H]QNB as a radioligand. | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5). |
| AID77365 | Efficacy relative to that of carbachol | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| AID77702 | Maximum contractile response relative to that elicited by carbachol was measured in guinea pig ileum | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| AID113327 | ED50 value as cholinergic agonist by measuring salivation in mice (in vivo) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Cholinergic activity of acetylenic imidazoles and related compounds. |
| AID77639 | Equilibrium dissociation constant receptor complex, measured in guinea pig urinary bladder | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| AID77638 | Equilibrium dissociation constant receptor complex, measured in guinea pig ileum | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| AID231029 | Muscarinic 1 receptor agonistic activity as the selectivity ratio of Ki against [3H]-QNB+ Gpp(NH)p to that of [3H]PZ | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5). |
| AID124472 | Antimuscarinic activity on the intact mice.(Dose required to double the dose of oxotremorine inducing a predetermined tremor intensity.) | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| Phenyl-substituted analogues of oxotremorine as muscarinic antagonists. |
| AID112394 | Tremorolytic activity administered intraperitoneally to mice | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| AID123418 | Dose required to double the dose of oxotremorine inducing a predetermined (grade 2) tremor intensity in mice | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| Derivatives of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID101704 | Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart. | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives. |
| AID142227 | Inhibition of [3H]N-methylscopolamine binding to muscarinic acetylcholine receptor of rat cerebral cortex. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| Phenyl-substituted analogues of oxotremorine as muscarinic antagonists. |
| AID113329 | ED50 value determined as oxotremorine antagonism by measuring lacrimation in mice (in vivo) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Cholinergic activity of acetylenic imidazoles and related compounds. |
| AID141065 | Muscarinic acetylcholine receptor M3 agonistic/antagonistic activity in guinea pig ileum | 1992 | Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
| Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID142020 | Percent inhibition against muscarinic acetylcholine receptor M4 from NG108-15 cell line | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides. |
| AID231028 | Muscarinic 1 receptor agonistic activity as the selectivity ratio of Ki against [3H]-QNB to that of [3H]PZ | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5). |
| AID141075 | Dissociation constant for complex with muscarinic acetylcholine receptor M3 of guinea pig ileum | 1992 | Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
| Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID101700 | Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex. | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives. |
| AID114478 | Central muscarinic activity administered intraperitoneally to mice, expressed as analgesia | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| AID231030 | Muscarinic 2 receptor agonistic activity was determined as the selectivity ratio of Ki against [3H]QNB+ Gpp(NH)p to that of [3H]QNB | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5). |
| AID77367 | Efficacy relative to that of carbachol, measured in guinea pig ileum | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| Derivatives of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID231701 | Relative [3H]QNB and [3H]-CD binding to muscarinic M2 receptor | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives. |
| AID77704 | Maximum contractile response relative to that elicited by carbachol, in guinea pig ileum | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| Derivatives of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID142217 | Binding activity to muscarinic acetylcholine receptor in rat heart, assayed using [3H]-QNB as a radioligand. | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5). |
| AID113331 | ED50 value determined as oxotremorine antagonism by measuring tremors in mice (in vivo) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Cholinergic activity of acetylenic imidazoles and related compounds. |
| AID141066 | Maximum contractile response relative to carbachol (E max) in guinea pig ileum as muscarinic acetylcholine receptor M3 agonistic/antagonistic activity | 1992 | Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
| Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID142894 | The agonist ratio as the ratio of Ki against [3H]QNB to that of [3H]-CD | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5). |
| AID141333 | Percent binding affinity at muscarinic acetylcholine receptor M3 from SK-N-SH human neuroblastoma cells in presence of [3H]NMS | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides. |
| AID75758 | In vitro effective concentration required to agonise oxotremorine-induced tremors in guinea pig ileum. | 1989 | Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
| Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. |
| AID113328 | ED50 value as cholinergic agonist by measuring tremors in mice (in vivo) | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Cholinergic activity of acetylenic imidazoles and related compounds. |
| AID141145 | Determination of dissociation constant from antimuscarinic activity on isolated guinea pig ileum. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| Phenyl-substituted analogues of oxotremorine as muscarinic antagonists. |
| AID77703 | Maximum contractile response relative to that elicited by carbachol was measured in guinea pig urinary bladder | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |