| Assay ID | Title | Year | Journal | Article |
|---|
| AID134595 | LD50 in mice following i.v. administration. | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 2. Non-glycolates. |
| AID77620 | Antimuscarinic activity was assayed for its ability to block the acetyl-choline induced contraction of the guinea pig ileum | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5
| 6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent. |
| AID140897 | Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]QNB from guinea pig cerebral cortex | 1995 | Journal of medicinal chemistry, Feb-03, Volume: 38, Issue:3
| 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships. |
| AID1695445 | Trypanocidal activity against Trypanosoma cruzi Y intracellular amastigote form infected in monkey LLC-MK2 cells | 2020 | RSC medicinal chemistry, Nov-18, Volume: 11, Issue:11
| On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors. |
| AID1695446 | Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2020 | RSC medicinal chemistry, Nov-18, Volume: 11, Issue:11
| On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors. |
| AID135107 | Anti-tremorine effect in mice following s.c. administration. | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 2. Non-glycolates. |
| AID142898 | Inhibition of (-)-[3H]-QNB muscarinic acetylcholine receptor binding on rat/ dog ventricular muscle | 1982 | Journal of medicinal chemistry, Sep, Volume: 25, Issue:9
| Analogues of 3-quinuclidinyl benzilate. |
| AID1148065 | Toxicity in sc dosed albino mouse assessed as mydriasis measured 120 mins post medication | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID141077 | Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]QNB from guinea pig parotid gland | 1995 | Journal of medicinal chemistry, Feb-03, Volume: 38, Issue:3
| 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships. |
| AID140924 | In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384 | 1995 | Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
| Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates. |
| AID128205 | Induction of mydriasis in mice following s.c. administration. | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 2. Non-glycolates. |
| AID1090601 | Displacement of [3H]QNB from Drosophila melanogaster mAChR by scintillation counting | 2007 | Journal of agricultural and food chemistry, Mar-21, Volume: 55, Issue:6
| Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists. |
| AID16907 | Biodistribution in rat striatum at 3 hr after dose administration. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor. |
| AID141150 | Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig. | 1997 | Journal of medicinal chemistry, Nov-07, Volume: 40, Issue:23
| Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships. |
| AID1148063 | Toxicity in sc dosed albino mouse assessed as mydriasis measured 30 mins post medication | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID226399 | Muscarinic receptor binding comparison to QNB, Relative binding index(RBI) | 1982 | Journal of medicinal chemistry, Sep, Volume: 25, Issue:9
| Analogues of 3-quinuclidinyl benzilate. |
| AID1148060 | Anti-tremorine activity against sc dosed albino mouse assessed as normalized dose for reversal of tremorine-induced spontaneous activity depression | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID1695448 | Selectivity index, ratio of CC50 for human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay to EC50 for Trypanosoma cruzi Y intracellular amastigote form infected in monkey LLC-MK2 cells | 2020 | RSC medicinal chemistry, Nov-18, Volume: 11, Issue:11
| On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors. |
| AID141149 | Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea Pig. | 1997 | Journal of medicinal chemistry, Nov-07, Volume: 40, Issue:23
| Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships. |
| AID674902 | Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting | 2012 | Bioorganic & medicinal chemistry, Aug-15, Volume: 20, Issue:16
| Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT). |
| AID1148070 | Anti-tremorine activity against sc dosed albino mouse assessed as normalized dose for reversal of tremorine-induced spontaneous activity depression measured 120 mins post medication | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID142895 | Binding affinity constant for muscarinic acetylcholine receptor from rat corpus striatum | 1991 | Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
| Synthesis and muscarinic cholinergic receptor affinities of 3-quinuclidinyl alpha-(alkoxyalkyl)-alpha-aryl-alpha-hydroxyacetates. |
| AID16721 | Biodistribution in rat cortex at 3 hr after dose administration. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor. |
| AID141140 | In vitro functional activity in isolated urinary bladder strips from Guinea Pig | 1995 | Journal of medicinal chemistry, Feb-03, Volume: 38, Issue:3
| 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships. |
| AID1148062 | Toxicity in sc dosed albino mouse assessed as mydriasis measured 15 mins post medication | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID157520 | Inhibition of carbachol-induced release of alpha-amylase from pancreatic acini from rat was determined | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5
| 6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent. |
| AID142111 | Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart | 1995 | Journal of medicinal chemistry, Feb-03, Volume: 38, Issue:3
| 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships. |
| AID1695449 | Selectivity index, ratio of CC50 for monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay to EC50 for Trypanosoma cruzi Tulahuen LacZ intracellular amastigote form infected in monkey LLC-MK2 cells incubated for 72 | 2020 | RSC medicinal chemistry, Nov-18, Volume: 11, Issue:11
| On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors. |
| AID140893 | In vitro binding affinity against bovine striatal membrane using [3H]pirenzepine | 1995 | Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
| Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates. |
| AID141151 | Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the parotid gland from Guinea Pig. | 1997 | Journal of medicinal chemistry, Nov-07, Volume: 40, Issue:23
| Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships. |
| AID1148061 | Toxicity in iv dosed mouse | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID16713 | Biodistribution in rat cerebellum at 3 hr after dose administration. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor. |
| AID79352 | Antimuscarinic activity was assayed for its ability to block the acetyl-choline induced contraction of the guinea pig ileum | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5
| 6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent. |
| AID1695444 | Trypanocidal activity against Trypanosoma cruzi Tulahuen LacZ intracellular amastigote form infected in monkey LLC-MK2 cells incubated for 72 hrs by chlorophenol red beta-D-galactopyranoside substrate based spectrophotometric assay | 2020 | RSC medicinal chemistry, Nov-18, Volume: 11, Issue:11
| On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors. |
| AID20502 | Relative lipophilicity was determined | 1991 | Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
| Synthesis and muscarinic cholinergic receptor affinities of 3-quinuclidinyl alpha-(alkoxyalkyl)-alpha-aryl-alpha-hydroxyacetates. |
| AID1148064 | Toxicity in sc dosed albino mouse assessed as mydriasis measured 60 mins post medication | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID1148067 | Toxicity in sc dosed albino mouse assessed as mydriasis measured 360 mins post medication | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID1148069 | Anti-tremorine activity against sc dosed albino mouse assessed as normalized dose for reversal of tremorine-induced spontaneous activity depression measured 60 mins post medication | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID141085 | In vitro binding affinity against guinea pig ileum using [3H]N-methylscopolamine | 1995 | Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
| Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates. |
| AID1148068 | Anti-tremorine activity against sc dosed albino mouse assessed as normalized dose for reversal of tremorine-induced spontaneous activity depression measured 30 mins post medication | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID16705 | Biodistribution in rat blood at 3 hr after dose administration. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor. |
| AID141152 | Affinity for Muscarinic acetylcholine receptors in urinary bladder from Guinea Pig by (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB displacement. | 1997 | Journal of medicinal chemistry, Nov-07, Volume: 40, Issue:23
| Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships. |
| AID1695447 | Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2020 | RSC medicinal chemistry, Nov-18, Volume: 11, Issue:11
| On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors. |
| AID1148059 | Toxicity in sc dosed albino mouse assessed as mydriasis | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID1090602 | Displacement of [3H]AF-DX 384 from Drosophila melanogaster mAChR by scintillation counting | 2007 | Journal of agricultural and food chemistry, Mar-21, Volume: 55, Issue:6
| Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists. |
| AID1148071 | Anti-tremorine activity against sc dosed albino mouse assessed as normalized dose for reversal of tremorine-induced spontaneous activity depression measured 240 mins post medication | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID16728 | Biodistribution in rat heart at 3 hr after dose administration. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor. |
| AID141156 | Binding affinity for muscarinic acetylcholine receptor by measuring displacement of [3H]QNB from guinea pig urinary bladder | 1995 | Journal of medicinal chemistry, Feb-03, Volume: 38, Issue:3
| 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships. |
| AID1148066 | Toxicity in sc dosed albino mouse assessed as mydriasis measured 240 mins post medication | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates. |
| AID142896 | Relative binding index [KA/KA(QNB)] to quiniclidine in muscarinic acetylcholine receptor from rat corpus | 1991 | Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
| Synthesis and muscarinic cholinergic receptor affinities of 3-quinuclidinyl alpha-(alkoxyalkyl)-alpha-aryl-alpha-hydroxyacetates. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1345343 | Human M3 receptor (Acetylcholine receptors (muscarinic)) | 1987 | The EMBO journal, Dec-20, Volume: 6, Issue:13
| Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. |
| AID1345286 | Human M1 receptor (Acetylcholine receptors (muscarinic)) | 1987 | The EMBO journal, Dec-20, Volume: 6, Issue:13
| Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. |
| AID1345465 | Human M4 receptor (Acetylcholine receptors (muscarinic)) | 2001 | Brain research, Oct-05, Volume: 915, Issue:1
| Interaction of anandamide with the M(1) and M(4) muscarinic acetylcholine receptors. |
| AID1345286 | Human M1 receptor (Acetylcholine receptors (muscarinic)) | 2001 | Brain research, Oct-05, Volume: 915, Issue:1
| Interaction of anandamide with the M(1) and M(4) muscarinic acetylcholine receptors. |
| AID1345326 | Human M2 receptor (Acetylcholine receptors (muscarinic)) | 1987 | The EMBO journal, Dec-20, Volume: 6, Issue:13
| Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. |
| AID1345465 | Human M4 receptor (Acetylcholine receptors (muscarinic)) | 1987 | The EMBO journal, Dec-20, Volume: 6, Issue:13
| Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. |
| AID430616 | Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting | 2009 | Journal of medicinal chemistry, Aug-27, Volume: 52, Issue:16
| Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)ace |
| AID101556 | Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography. |
| AID141450 | Pseudo hill coefficient determined at Muscarinic acetylcholine receptor M1 | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. |
| AID104018 | Ability to displace [3H]pirenzepine (PZ) from M1 receptor in rat cortex homogenate | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography. |
| AID142935 | Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. |
| AID196390 | Evaluated for the phosphatidyl inositol turnover at Muscarinic acetylcholine receptor M1 in rat cortex | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. |
| AID231933 | Ratio for Ki for M2 (inhibition of adenylate cyclase of rat heart) to Ki for M1 (phosphatidyl inositol turnover in rat cortex) | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. |
| AID231529 | Ratio of binding affinity towards M2 (bovine striatum) to M1 (rat myocardium) receptor | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. |
| AID141695 | In vitro binding affinity towards Muscarinic acetylcholine receptor M1 using [3H]QNB as radioligand from rat heart tissue | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor. |
| AID142796 | Pseudo hill coefficient determined at Muscarinic acetylcholine receptor M2 | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. |
| AID34453 | Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. |
| AID430629 | Toxicity in Swiss mouse assessed as neurobiological state and occurrence of xerostomia at 30 mg/kg, ip up to 24 hrs | 2009 | Journal of medicinal chemistry, Aug-27, Volume: 52, Issue:16
| Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)ace |
| AID101728 | Ability to displace [3H]N-methylscopolamine (NMS) from M3 receptor in rat submaxillary gland homogenate | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography. |
| AID142010 | In vitro binding affinity towards Muscarinic acetylcholine receptor M4 using [3H]QNB as radioligand from rat heart tissue | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor. |
| AID142921 | Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatum | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists. |
| AID142950 | Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates | 1991 | Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
| Muscarinic receptor binding profile of para-substituted caramiphen analogues. |
| AID233598 | Ratio of Ki (M1 receptor) to Ki (M2 receptor) was determined | 1991 | Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
| Muscarinic receptor binding profile of para-substituted caramiphen analogues. |
| AID142932 | In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor. |
| AID141829 | Displacement of [3H]pirenzepine from muscarinic acetylcholine receptor M1 in rat cortex homogenates | 1991 | Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
| Muscarinic receptor binding profile of para-substituted caramiphen analogues. |
| AID430617 | Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting | 2009 | Journal of medicinal chemistry, Aug-27, Volume: 52, Issue:16
| Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)ace |
| AID430618 | Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting | 2009 | Journal of medicinal chemistry, Aug-27, Volume: 52, Issue:16
| Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)ace |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |