| Assay ID | Title | Year | Journal | Article |
|---|
| AID142368 | Ratio of geometric mean of the affinity constant (Kapp) of NMS/OXO-M | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives. |
| AID142207 | In vitro ability to displace [3H]oxotremorine-M from the muscarinic receptor in rat cerebral cortical membranes | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID142211 | In vitro binding affinity against cortical muscarinic acetylcholine receptor measured by displacement of [3H]NMS. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives. |
| AID140989 | In vitro contraction of guinea pig myenteric plexus preparation (mediated by Muscarinic M3 receptor) | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID142100 | In vitro ability to displace [3H]N-methylscopolamine from the muscarinic receptor in rat cerebral cortical membranes | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID142208 | In vitro ability to displace muscarinic agonist [3H]oxotremorine-M from high affinity state of the receptor in rat cerebral cortical membranes | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID141444 | Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion (mediated by Muscarinic M1 receptor | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID141846 | In vitro evaluation for the relative maximum against Muscarinic M1 receptor compare to muscarine | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID141445 | Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion (mediated by Muscarinic M1 receptor) | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID142369 | The selectivity ratio of Kapp of NMS/OXO -M | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
| Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors. |
| AID229771 | Ratio of Kapp(NMS)/Kapp(OXO-M) | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID142743 | In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor) | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID142749 | In Vitro evaluation for the relative maximum against Muscarinic M2 receptor compare to carbachol | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID140999 | In vitro evaluation for the relative maximum against Muscarinic M3 receptor compare to carbachol | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. |
| AID142209 | In vitro binding affinity against muscarinic acetylcholine receptor from rat cortical homogenates using [3H]N-methylscopolamine as radioligand | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
| Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors. |
| AID142210 | In vitro binding affinity against muscarinic acetylcholine receptor from rat cortical homogenates using [3H]oxotremorine-M radioligand | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
| Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors. |
| AID186651 | Stimulation of phosphatidyl inositol(PI) hydrolysis as compared to that of carbachol, was determined in rat hippocampal slices | 1998 | Journal of medicinal chemistry, Oct-22, Volume: 41, Issue:22
| Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone. |
| AID142212 | In vitro binding affinity against cortical muscarinic acetylcholine receptor measured by displacement of [3H]OXO-M. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives. |
| AID142218 | Binding affinity against Muscarinic acetylcholine receptor using [3H]-OXO-M as the radioligand. | 1998 | Journal of medicinal chemistry, Oct-22, Volume: 41, Issue:22
| Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |