Page last updated: 2024-12-08
n-benzyl-n-hydroxy-5-phenylpentamide
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
N-benzyl-N-hydroxy-5-phenylpentanamide: a hydroxamic acid class lipoxygenase inhibitor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 157806 |
| CHEMBL ID | 301253 |
| SCHEMBL ID | 1271129 |
| MeSH ID | M0226256 |
Synonyms (12)
| Synonym |
|---|
| n-bhpp |
| CHEMBL301253 , |
| 158999-12-3 |
| n-benzyl-n-hydroxy-5-phenylpentamide |
| bdbm50016680 |
| 5-phenyl-pentanoic acid benzyl-hydroxy-amide |
| n-benzyl-n-hydroxy-5-phenylpentanamide |
| n-hydroxy-n-(phenylmethyl)benzenepentanamide |
| benzenepentanamide, n-hydroxy-n-(phenylmethyl)- |
| SCHEMBL1271129 |
| DTXSID60166550 |
| PD182664 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (3)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 (µMol) | 0.1500 | 0.0001 | 1.6847 | 9.3200 | AID6723 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.0500 | 0.0046 | 2.0182 | 10.0000 | AID7071 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.3000 | 0.3000 | 0.4000 | 0.5000 | AID3118 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (30)
Molecular Functions (6)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| arachidonate 5-lipoxygenase activity | Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) |
| arachidonate 12(S)-lipoxygenase activity | Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) |
| iron ion binding | Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) |
| protein binding | Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) |
| hydrolase activity | Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) |
| arachidonate 8(S)-lipoxygenase activity | Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Ceullar Components (11)
Bioassays (5)
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.80
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.80) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||