| Assay ID | Title | Year | Journal | Article |
|---|
| AID1345905 | Human ETA receptor (Endothelin receptors) | 1999 | Stroke, Mar, Volume: 30, Issue:3
| Blockade and reversal of endothelin-induced constriction in pial arteries from human brain. |
| AID1345905 | Human ETA receptor (Endothelin receptors) | 1997 | The Journal of pharmacology and experimental therapeutics, Feb, Volume: 280, Issue:2
| Affinity and selectivity of PD156707, a novel nonpeptide endothelin antagonist, for human ET(A) and ET(B) receptors. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID15842 | Aqueous solubility in pH 7.4 phosphate buffer | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Butenolide endothelin antagonists with improved aqueous solubility. |
| AID66692 | Tested for binding affinity for human Endothelin B receptor by measuring its ability to displace [125I]-ET-3 from chinese hamster ovary cells(CHO) | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546). |
| AID66186 | In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor | 1998 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13
| Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. |
| AID196820 | Compound was evaluated for the functional assay performed by obtaining ET-1 concentration-response curves [pA2(ETA)] in isolated rat aortic rings | 1998 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13
| Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. |
| AID68489 | Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO) | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546). |
| AID18622 | Bioavailability in rat | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546). |
| AID166817 | Compound was evaluated for the functional assay performed by obtaining ET-1 concentration-response curves [pA2(ETB)] in isolated rabbit jugularis vein | 1998 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13
| Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. |
| AID23605 | Pharmacokinetic profile-half life was evaluated in rats upon intravenous administration | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546). |
| AID68338 | Antagonistic activity against human Endothelin A receptor expressed in LtK | 1995 | Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
| Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists. |
| AID67052 | pA2 value towards endothelin receptor A was determined as functional ETA antagonism | 1998 | Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1
| Endothelin antagonists: evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster. |
| AID66717 | In vitro ability to inhibit specific [125I]ET1 binding to porcine kidney (inner medulla) membranes Endothelin B receptor | 1998 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 8, Issue:13
| Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. |
| AID66545 | Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed). | 1995 | Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
| Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |