| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID281132 | Antagonist activity at human recombinant GLUK5/GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
| Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. |
| AID257198 | Antagonism on GLUK5 containing kainate induced depolarization of isolated neonatal rat dorsal root C-fibers | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. |
| AID1325321 | Antagonist activity at recombinant GluK3 receptor (unknown origin) expressed in Xenopus oocyte assessed as inhibition of glutamate-induced current amplitude by voltage-clamp method | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
| Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands. |
| AID450957 | Displacement of [3H]CGP39653 from NMDA receptor in rat cortical membrane | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
| 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. |
| AID257202 | Displacement of [3H]kainate from rat GLUK6 receptor expressed in HEK293 cells | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. |
| AID450958 | Displacement of [3H]SYM2081 from rat recombinant iGluR6 expressed in baculovirus-infected insect Sf9 cells | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
| 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. |
| AID281134 | Antagonist activity at human recombinant GLUK6/GLUK2 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
| Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. |
| AID257201 | Displacement of [3H]SYM2081 from kainate receptor in rat brain membrane | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. |
| AID272852 | Displacement of [3H]glycine from Gly/NMDA receptor in rat cortical synaptic membrane at 100 uM | 2006 | Journal of medicinal chemistry, Oct-05, Volume: 49, Issue:20
| Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies. |
| AID450960 | Displacement of [3H]AMPA from wild type rat GluR2 S1S2 ligand binding core | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
| 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. |
| AID1325314 | Displacement of [3H]-kainate from kainate receptor in rat brain membranes after 60 mins | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
| Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands. |
| AID450955 | Displacement of [3H]SYM2081 from rat recombinant iGluR5-1b expressed in baculovirus-infected insect Sf9 cells | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
| 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. |
| AID262621 | Antagonist activity against AMPA receptor expressed in motoneurones by inhibition of fDR-VRP in the neonatal rat spinal cord | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8
| Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists. |
| AID262620 | Antagonist activity against GLUK5-containing kainate receptor by inhibition of kainate-induced depolarization of neonatal rat dorsal root fibers | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8
| Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists. |
| AID281120 | Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
| Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. |
| AID450956 | Displacement of [3H]kainic acid from kainate receptor in rat cortical membrane | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
| 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. |
| AID272850 | Displacement of [3H]KA from high affinity KA receptor in rat cortical membrane | 2006 | Journal of medicinal chemistry, Oct-05, Volume: 49, Issue:20
| Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies. |
| AID257200 | Displacement of [3H](S)-5-fluorowillardiine from AMPA receptor in rat brain membrane | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. |
| AID262622 | Displacement of [3H]kainate from rat GLUK6 expressed in HEK293 cells | 2006 | Journal of medicinal chemistry, Apr-20, Volume: 49, Issue:8
| Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists. |
| AID281129 | Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
| Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. |
| AID257196 | Antagonist activity on AMPA receptor expressed on rat motoneurons by its ability to reduce the fast component dorsal root evoked ventral root potential (fDR-VRP) | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. |
| AID281133 | Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
| Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. |
| AID450961 | Displacement of [3H]S-glutamate from rat GluR5 S1S2 ligand binding core expressed in Escherichia coli (DE3) | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
| 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. |
| AID450954 | Displacement of [3H]AMPA from AMPA receptor in rat cortical membrane | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
| 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. |
| AID450959 | Displacement of [3H]SYM2081 from rat recombinant iGluR7A expressed in baculovirus-infected insect Sf9 cells | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
| 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. |
| AID1325313 | Displacement of [3H]-AMPA from AMPA receptor in rat brain membranes after 30 mins | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22
| Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands. |
| AID272848 | Displacement of [3H]AMPA from AMPA receptor in rat cortical synaptic membrane | 2006 | Journal of medicinal chemistry, Oct-05, Volume: 49, Issue:20
| Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies. |
| AID281122 | Antagonist activity at native AMPA receptor assessed as fDR-VRP reduction of neonatal rat spinal cord motorneurones | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
| Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. |
| AID272856 | Displacement of [3H]KA from low affinity KA receptor in rat cortical membrane | 2006 | Journal of medicinal chemistry, Oct-05, Volume: 49, Issue:20
| Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies. |
| AID281131 | Antagonist activity at human recombinant GLUK5/GLUK2 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
| Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. |
| AID281130 | Antagonist activity at human recombinant GLUK5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
| Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2006 | The Journal of neuroscience : the official journal of the Society for Neuroscience, Mar-15, Volume: 26, Issue:11
| Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |