Trimethylphosphine oxide (TMPO) is a colorless, crystalline solid that is commonly used as a ligand in coordination chemistry. It is synthesized by the oxidation of trimethylphosphine, often using hydrogen peroxide or air. TMPO is a strong donor ligand and forms stable complexes with a wide range of metals, including transition metals, lanthanides, and actinides. The coordination of TMPO to metals can influence the reactivity and selectivity of these metals in various catalytic reactions. TMPO has also been investigated for its potential applications in organic synthesis, materials science, and medicinal chemistry. For example, it has been employed as a reagent for the activation of carbonyl compounds, as a building block for the synthesis of novel polymers, and as a potential drug candidate for the treatment of cancer. The study of TMPO is motivated by its versatility, its ability to form stable complexes with a wide range of metals, and its potential applications in various fields.'
trimethylphosphine oxide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 69609 |
| CHEMBL ID | 5189319 |
| MeSH ID | M0522429 |
| Synonym |
|---|
| (ch3)3po |
| 676-96-0 |
| trimethylphosphine oxide |
| inchi=1/c3h9op/c1-5(2,3)4/h1-3h |
| me3po |
| dimethylphosphorylmethane |
| FT-0694049 |
| 4m39gk79dv , |
| einecs 211-633-9 |
| unii-4m39gk79dv |
| LRMLWYXJORUTBG-UHFFFAOYSA-N |
| phosphine oxide, trimethyl- |
| AKOS024438025 |
| DTXSID90217923 |
| trimethylphosphine oxide, 98% |
| mfcd00013910 |
| AS-58331 |
| CHEMBL5189319 |
| trimethylphosphineoxide |
| (dimethylphosphoryl)methane |
| F20530 |
| CS-0107712 |
| SY061294 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1880635 | Tanol-water partition coefficient, logP of compound by shake flask method based 31P-NMR analysis | 2022 | Journal of medicinal chemistry, 06-23, Volume: 65, Issue:12 | Studying Lipophilicity Trends of Phosphorus Compounds by |
| AID1880636 | Basicity of hydrogen bond, pKHB of compound by IR spectroscopy | 2022 | Journal of medicinal chemistry, 06-23, Volume: 65, Issue:12 | Studying Lipophilicity Trends of Phosphorus Compounds by |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 4 (66.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (36.18) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||