| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group. | 2.06 | 1 | 0 | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite |
aristolochic acid i
aristolochic acid I: phospholipase A inhibitor. aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic. | 2.05 | 1 | 0 | aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound | carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin |
(+-)stylopine
[no description available] | 1.97 | 1 | 0 | | |
2-methylpentane
Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning. | 2.06 | 1 | 0 | alkane | |
n-hexane
hexane : An unbranched alkane containing six carbon atoms. | 2.06 | 1 | 0 | alkane;
volatile organic compound | neurotoxin;
non-polar solvent |
ethyl acetate
ethyl acetate : The acetate ester formed between acetic acid and ethanol. | 2.06 | 1 | 0 | acetate ester;
ethyl ester;
volatile organic compound | EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor;
metabolite;
polar aprotic solvent;
Saccharomyces cerevisiae metabolite |
isocorydine
isocorydine: from root tubers of Stephania Kwangsiensis H.S. Lo; RN given refers to (+-)-isomer; structure in Merck Index, 9th ed, #5017 | 2.05 | 1 | 0 | aporphine alkaloid | |
corydine
corydine: structure given in first source; RN given refers to (S)-isomer | 2.05 | 1 | 0 | | |
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid. | 2.06 | 1 | 0 | benzenes;
phenyl acetates | |
canadine
canadine: RN given refers to cpd without isomeric designation; structure. canadine : A berberine alkaloid that is 5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline substituted by methoxy groups at positions 9 and 10. | 2.05 | 1 | 0 | aromatic ether;
berberine alkaloid;
organic heteropentacyclic compound;
oxacycle | |
aristolactam i
aristolactam I: metabolite of aristolochic acid; forms DNA adducts; | 2.05 | 1 | 0 | | |
dicentrine
dicentrine: structure given in first source; RN refers to (S)-isomer | 2.05 | 1 | 0 | aporphine alkaloid | |
berbine
berbine: structure | 2.15 | 1 | 0 | berberine alkaloid;
isoquinoline alkaloid fundamental parent;
organic heterotetracyclic compound | |
aristolochic acid ii
aristolochic acid II: structure given in first source. aristolochic acid B : An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions and by a nitro group at position 10. | 2.05 | 1 | 0 | aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound | carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin |
aporphine
aporphine: RN given refers to parent cpd without isomeric designation. aporphine : An isoquinoline alkaloid that is the N-methyl derivative of 5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline. | 2.15 | 1 | 0 | aporphine alkaloid;
isoquinoline alkaloid fundamental parent;
tertiary amino compound | |
roemerine
roemerine: from root tubers of Stephania kwangsiensis H.S. Lo; RN given refers to (R)-isomer; synonym aporeine refers to (S)-isomer; structure in Merck Index, 9th ed, #779 | 1.97 | 1 | 0 | isoquinoline alkaloid | |
corytuberine
corytuberine: structure. (S)-corytuberine : An aporphine alkaloid that is aporphine which is substituted by hydroxy groups at positions 1 and 11, and by methoxy groups at positions 2 and 10 (the S enantiomer). | 2.05 | 1 | 0 | aporphine alkaloid;
aromatic ether;
organic heterotetracyclic compound;
polyphenol;
tertiary amino compound | plant metabolite |
xylopine
xylopine: RN given refers to (R)-isomer; RN for cpd without isomeric designation not available 3/90; structure given in first source | 6.97 | 1 | 0 | aporphine alkaloid | |
aristolochic acid D
aristolochic acid D : An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions, by an hydroxy group at position 6, by a methoxy group at position 8, and by a nitro group at position 10. | 2.05 | 1 | 0 | aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound | carcinogenic agent;
metabolite;
nephrotoxin;
toxin |
aristolochic acid c
aristolochic acid C: isolated from Aristolochia contorta. aristolochic acid C : An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions, by an hydroxy group at position 6, and by a nitro group at position 10. | 2.05 | 1 | 0 | aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound | carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin |
tetrahydropalmatine
[no description available] | 2.15 | 1 | 0 | | |
salutaridine
[no description available] | 2.46 | 2 | 0 | morphinane alkaloid | anti-HBV agent;
metabolite |
sinomenine
sinomenine: isolated from root of Sinomenium acutum; antirheumatic, antineuralgic | 2.05 | 1 | 0 | morphinane alkaloid | |
morphinans
Morphinans: Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS. | 2.06 | 1 | 0 | isoquinoline alkaloid fundamental parent;
morphinane alkaloid | |
crebanine
crebanine: RN refers to R-isomer; structure given in first source | 2.72 | 3 | 0 | | |
aristolactam aiiia
Aristolactam AIIIa: polo-like kinase 1 (Plk1) inhibitor; structure in first source | 2.05 | 1 | 0 | | |