| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group. | 2.05 | 1 | 0 | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite |
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen. | 2.39 | 2 | 0 | pyrrole;
secondary amine | |
chloranil
Chloranil: A quinone fungicide used for treatment of seeds and foliage.. tetrachloro-1,4-benzoquinone : A member of the class of 1,4-benzoquiones that is 1,4-benzoquinone in which all four hydrogens are substituted by chlorines. | 2.05 | 1 | 0 | 1,4-benzoquinones;
organochlorine compound | EC 2.7.1.33 (pantothenate kinase) inhibitor;
metabolite |
tropine
[no description available] | 1.92 | 1 | 0 | | |
diphenhydramine hydrochloride
Antitussive Agents: Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.. diphenhydramine hydrochloride : The hydrochloride salt of diphenhydramine. | 2 | 1 | 0 | hydrochloride;
organoammonium salt | anti-allergic agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
sedative |
monocrotaline
Monocrotaline: A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment. | 8.52 | 8 | 0 | pyrrolizidine alkaloid | |
2'-deoxy-5'-adenosine monophosphate
2'-deoxy-5'-adenosine monophosphate: RN given refers to parent cpd. 2'-deoxyadenosine 5'-monophosphate : A purine 2'-deoxyribonucleoside 5'-monophosphate having adenine as the nucleobase. | 2 | 1 | 0 | 2'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-monophosphate | fundamental metabolite |
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus. | 2 | 1 | 0 | dihydrogen | |
2-chloranil
[no description available] | 2.05 | 1 | 0 | | |
indicine
indicine: RN given refers to (1R-(1alpha,7(2R*,3S*),7abeta))-isomer | 2.73 | 3 | 0 | carboxylic ester;
pyrrolizines | |
platynecine
platynecine: structure in first source | 2.15 | 1 | 0 | | |
monocrotaline pyrrole
monocrotaline pyrrole: RN given refers to (13alpha,14alpha)-isomer | 2.06 | 1 | 0 | | |
dehydroretronecine
dehydroretronecine: major pyrrole metabolite of monocrotaline; RN given refers to cpd without isomeric designation | 7.72 | 3 | 0 | | |
heliotrine
[no description available] | 2.03 | 1 | 0 | pyrrolizines | |
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily. | 1.97 | 1 | 0 | | |
senecionine
senecionine: RN given refers to parent cpd; structure. senecionine : A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio. | 7.68 | 3 | 0 | lactone;
pyrrolizidine alkaloid;
tertiary alcohol | plant metabolite |
otonecine
otonecine: structure in first source | 3.15 | 5 | 0 | tertiary amine | |
retrorsine
retrorsine: RN given refers to cpd without isomeric designation; structure | 2.52 | 2 | 0 | macrolide | |
riddelliine
riddelliine: structure. riddelliine : A macrodiolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16. | 2.43 | 2 | 0 | macrodiolide;
olefinic compound;
organic heterotricyclic compound;
pyrrolizine alkaloid | carcinogenic agent;
genotoxin;
mutagen |
seneciphylline
seneciphylline: RN given refers to parent cpd; structure | 7.37 | 2 | 0 | pyrrolizine alkaloid | |
senkirkine
senkirkine: macrocyclic secopyrrolizidine alkaloid from Senecio; structure given in first source; RN given refers to senkirkine | 2.1 | 1 | 0 | macrolide | |
riddelliine n-oxide
riddelliine N-oxide: structure given in first source; from Riddell groundsel (Senecio riddellii). riddelliine N-oxide : A pyrrolizine alkaloid that is 13,19-didehydrosenecionane bearing two additional hydroxy substituents at positions 12 and 18, two additional oxo groups at positions 11 and 16 and an N-oxido substituent. | 2.04 | 1 | 0 | diol;
macrocyclic lactone;
olefinic compound;
organic heterotricyclic compound;
primary alcohol;
pyrrolizine alkaloid;
tertiary alcohol;
tertiary amine oxide | carcinogenic agent;
genotoxin;
human xenobiotic metabolite;
Jacobaea metabolite;
mutagen;
rat metabolite |
necic acid
necic acid: occur as diesters of pyrrolizidine bases in alkaloids; RN given refers to (Z)-isomer; structure | 2.41 | 2 | 0 | | |
piperidines
Piperidines: A family of hexahydropyridines. | 2.03 | 1 | 0 | | |
clivorine
clivorine: isolated from Ligularia dentata; structure in first source | 2 | 1 | 0 | | |
2'-deoxyguanosine 5'-phosphate
2'-deoxyguanosine 5'-phosphate: RN given refers to parent cpd.. 2'-deoxyguanosine 5'-monophosphate : A purine 2'-deoxyribonucleoside 5'-monophosphate having guanine as the nucleobase. | 2 | 1 | 0 | deoxyguanosine phosphate;
guanyl deoxyribonucleotide;
purine 2'-deoxyribonucleoside 5'-monophosphate | Escherichia coli metabolite;
mouse metabolite |
phosphorus radioisotopes
Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes. | 2 | 1 | 0 | | |