Compounds > necic acid
Page last updated: 2024-11-11

necic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

necic acid: occur as diesters of pyrrolizidine bases in alkaloids; RN given refers to (Z)-isomer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6440847
MeSH IDM0052574

Synonyms (13)

Synonym
necic acid
(2r,3r,5z)-5-ethylidene-2-hydroxy-2,3-dimethylhexanedioic acid
hexanedioic acid, 5-ethylidene-2-hydroxy-2,3-dimethyl-, (r-(r*,r*-(z)))-
unii-axn0570qie
axn0570qie ,
13588-16-4
platynecinic acid
(+)-senecic acid
senecionic acid
senecic acid [mi]
platynecic acid
hexanedioic acid, 5-ethylidene-2-hydroxy-2,3-dimethyl-, (2r,3r,5z)-)
Q27274182

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Lactating rats dosed with these differently labelled pyrrolizidine alkaloids (PAs) excreted within 3 h approx."( Transfer of [3H]pyrrolizidine alkaloids from Senecio vulgaris L. and metabolites into rat milk and tissues.
Heim, T; Lüthy, J; Schlatter, C, 1983)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (50.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.17 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.17)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (50.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (50.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
retronecine
retronecine: RN given refers to (1R-trans)-isomer; structure		2.4120pyrrolizines
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.610D-glucopyranoseepitope;
mouse metabolite
platynecine
platynecine: structure in first source		2.1510
senecionine
senecionine: RN given refers to parent cpd; structure. senecionine : A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.		1.9610lactone;
pyrrolizidine alkaloid;
tertiary alcohol		plant metabolite
otonecine
otonecine: structure in first source		2.1510tertiary amine
seneciphylline
seneciphylline: RN given refers to parent cpd; structure		1.9610pyrrolizine alkaloid
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Liver Injury, Drug-Induced
[description not available]		02.1510
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		02.1510
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9610