Page last updated: 2024-11-06
platynecine
Description
Platynecine is a pyrrolizidine alkaloid found in various plant species, including the genus Senecio. It exhibits a range of biological activities, including hepatotoxicity, genotoxicity, and carcinogenic potential. The compound's structural features, particularly its N-oxide form, contribute to its toxicity. Platynecine's biosynthesis involves a complex pathway involving multiple enzymatic steps and precursor molecules. Research on platynecine focuses on understanding its toxic mechanisms, identifying potential therapeutic targets, and developing strategies for mitigating its harmful effects. The compound's prevalence in various plants and its potential health risks have made it a subject of extensive study in toxicology, pharmacology, and environmental science.'
platynecine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 92791 |
| SCHEMBL ID | 15123213 |
| MeSH ID | M0477890 |
Synonyms (16)
| Synonym |
|---|
| platynecin |
| platynecine |
| qwoxstgogunugf-bwzbuefssa- |
| inchi=1/c8h15no2/c10-5-6-1-3-9-4-2-7(11)8(6)9/h6-8,10-11h,1-5h2/t6-,7-,8-/m1/s1 |
| qlu72l7vmn , |
| unii-qlu72l7vmn |
| 1h-pyrrolizine-1-methanol, hexahydro-7-hydroxy-, (1s-(1alpha,7alpha,7abeta))- |
| nsc 124683 |
| SCHEMBL15123213 |
| 1h-pyrrolizine-1-methanol, hexahydro-7-hydroxy-, (1s,7r,7ar)- |
| 1h-pyrrolizine-1-methanol, hexahydro-7-hydroxy-, (1s-(1.alpha.,7.alpha.,7a.beta.))- |
| (1s)-1,2-dihydroretronecine |
| platynecine, (-)- |
| (1s,7r,7ar)-hexahydro-7-hydroxy-1h-pyrrolizine-1-methanol |
| (-)-platynecine |
| DTXSID001020154 |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 20.47
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 20.47 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.63 (4.65) | | Search Engine Demand Index | 15.26 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |