mycoepoxydiene profile

mycoepoxydiene: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	11300750
CHEMBL ID	1290053
MeSH ID	M0452348

Synonym
CHEMBL1290053
mycoepoxydiene
[(2s,3s)-2-[(1r,6s,7r,8s)-8-methyl-9-oxabicyclo[4.2.1]nona-2,4-dien-7-yl]-6-oxo-2,3-dihydropyran-3-yl] acetate
DTXSID101036970

Excerpt	Reference
"Mycoepoxydiene (MED) is a polyketide isolated from a marine fungus associated with mangrove forests. "	( Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells. Chen, D; Huang, Y; Park, K; Shen, Y; Wang, J; Wang, R; Weimer, BC; Wu, X; Zhang, W; Zhao, B, 2010)
"Mycoepoxydiene (MED) is a polyketide isolated from a marine fungus associated with mangrove forest. "	( Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice. Chen, Q; Liu, K; Mo, PL; Shen, YM; Xia, XC; Yu, CD; Zhu, JW; Zhuang, MQ, 2013)
"Mycoepoxydiene (MED) is a polyketide isolated from the marine fungal Diaporthe sp. "	( Mycoepoxydiene inhibits activation of BV2 microglia stimulated by lipopolysaccharide through suppressing NF-κB, ERK 1/2 and toll-like receptor pathways. Chen, Q; Chen, T; Chen, W; Dou, X; Li, W; Li, Y; Shen, Y; Su, X; Wu, H; Yu, C; Zhang, Y, 2014)
"Mycoepoxydiene (MED) is a natural product isolated from a marine fungus that has shown promising inhibitory efficacy against HeLa cells in vitro."	( Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway. Deng, X; Jin, K; Li, L; Shen, Y; Song, S; Sun, X; Xu, Q, 2017)
"Mycoepoxydiene (MED) is a compound isolated from the marine fungal Diaporthe sp. "	( Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice. Chen, Q; Mo, P; Shen, Y; Xia, X; Yu, C; Zhu, J, 2013)
"Mycoepoxydiene (MED) is a cytotoxic polyketide that is isolated from the marine fungal strain Diaporthe sp. "	( Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-κB pathways. Shen, Y; Wang, J; Wu, X; Yi, Y; Zhang, L; Zhang, W; Zhao, B, 2012)
"Mycoepoxydiene (MED) is a polyketide isolated from a marine fungus associated with mangrove forests. "	( Mycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses through the suppression of TRAF6 polyubiquitination [corrected]. Chen, Q; Chen, T; Huang, Y; Li, W; Li, Y; Shen, Y; Yu, C; Zhang, W; Zhu, J, 2012)

Excerpt	Reference
"Mycoepoxydiene (MED) can inhibit Hsp90 function and induce apoptosis in cervical cancer cells."	( Heat shock protein 90 inhibitor mycoepoxydiene modulates kinase signaling in cervical cancer cells and inhibits in-vivo tumor growth. Deng, X; Lin, P; Lu, M; Lu, Y; Song, S; Wang, M; Yang, Y; Yi, Y; Zhang, L; Zheng, Z, 2015)

Bioassays (52)

Assay ID	Title	Year	Journal	Article
AID539085	Induction of apoptosis in human HeLa cells assessed as reduction in expression of Cdc2 after 12 hrs by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539079	Induction of apoptosis in human HeLa cells assessed as increase of dead cells at 12 uM using propidium iodide staining by flow cytometry	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539097	Induction of apoptosis in human HeLa cells assessed cell death up to 20 uM after 48 hrs using propidium iodide staining by flow cytometry in presence of JNK inhibitor 2 treated 1 hr before compound challenge	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539094	Induction of apoptosis in human HeLa cells assessed as increase in cytochrome C in cytoplasm at 21 uM after 20 hrs by Western blotting	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539069	Growth inhibition in human MDA-MB-435 cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539113	Induction of apoptosis in human HeLa cells assessed as reduction in expression of chk2 at 14 to 21 uM by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539108	Induction of apoptosis in human HeLa cells assessed as reduction in expression of p34 at 14 to 21 uM by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539088	Induction of apoptosis in human HeLa cells assessed as reduction in expression of WEE1 after 12 hrs by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539089	Induction of apoptosis in human HeLa cells assessed as reduction in expression of Myt1 after 12 hrs by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539087	Induction of apoptosis in human HeLa cells assessed as reduction in expression of GADD45alpha after 12 hrs by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539071	Growth inhibition in human MCF7 cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539074	Growth inhibition in human OVCAR-3 cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539081	Induction of apoptosis in human HeLa cells assessed as increase in actin stress fiber formation across cell body after 12 hrs by phase contrast microscopic analysis	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539065	Cytotoxicity against human KB cells by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539078	Induction of apoptosis in human HeLa cells assessed as increase of dead cells at 11 uM using propidium iodide staining by flow cytometry	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539091	Induction of apoptosis in human HeLa cells assessed as reduction in expression of chk2 after 12 hrs by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539070	Growth inhibition in human MDA-MB-231 cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539095	Induction of JNK phosphorylation at Thr183/Tyr185 in human HeLa cells at 21 uM after 30 mins by Western blotting	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539084	Induction of apoptosis in human HeLa cells assessed as reduction in expression of Cdc2 at 14 to 21 uM by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539072	Growth inhibition in human U2OS cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539114	Induction of JNK expression in human HeLa cells at 21 uM after 8 hrs by Western blotting	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539099	Induction of apoptosis in human HeLa cells assessed as increase in cleavage fragments of p17 and p12 at 21 uM after 12 to 28 hrs by Western blotting	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539105	Cell cycle arrest in human HeLa cells assessed as accumulation at sub-G1 phase at 21 uM after 36 hrs using propidium iodide staining by flow cytometry relative to control	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539116	Induction of apoptosis in human HeLa cells assessed as increase in PARP cleavage at 21 uM after 12 to 28 hrs by Western blotting	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539109	Induction of apoptosis in human HeLa cells assessed as reduction in expression of GADD45alpha at 14 to 21 uM by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539077	Induction of apoptosis in human HeLa cells assessed as increase of dead cells after 24 hrs using propidium iodide staining by flow cytometry	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539075	Growth inhibition in human A549 cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539068	Growth inhibition in human DU145 cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539098	Induction of apoptosis in human HeLa cells assessed cell death up to 20 uM after 48 hrs using propidium iodide staining by flow cytometry in presence of SB-203580 treated 1 hr before compound challenge	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539100	Induction of apoptosis in human HeLa cells assessed as increase in caspase-3 cleavage at 21 uM after 12 to 28 hrs by Western blotting in presence of z-VAD-fmk	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539066	Growth inhibition in human AGS cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539104	Cell cycle arrest in human HeLa cells assessed as accumulation at sub-G1 phase at 14 uM after 36 hrs using propidium iodide staining by flow cytometry relative to control	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539103	Cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 21 uM after 12 hrs using propidium iodide staining by flow cytometry relative to control	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539080	Induction of apoptosis in human HeLa cells assessed as morphological changes at 14 to 21 uM after 9 hrs by phase contrast microscopic analysis	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539076	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539107	Cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 21 uM after 36 hrs using propidium iodide staining by flow cytometry relative to control	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539110	Induction of apoptosis in human HeLa cells assessed as reduction in expression of WEE1 at 14 to 21 uM by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539096	Induction of p38 phosphorylation at Thr180/Tyr182 in human HeLa cells assessed at 21 uM after 30 mins by Western blotting	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539093	Induction of apoptosis in human HeLa cells assessed as increase in production of cyclin B1 at 14 to 21 uM after 12 hrs by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539082	Induction of apoptosis in human HeLa cells assessed as increase in actin stress fiber formation across cell body at 14 to 21 uM by phase contrast microscopic analysis	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539102	Induction of apoptosis in human HeLa cells assessed as disruption of tubulin cytoskeleton at 14 to 21 uM by phase contrast microscopic analysis	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539111	Induction of apoptosis in human HeLa cells assessed as reduction in expression of Myt1 at 14 to 21 uM by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539090	Induction of apoptosis in human HeLa cells assessed as reduction in expression of chk1 after 12 hrs by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539086	Induction of apoptosis in human HeLa cells assessed as reduction in expression of p34 after 12 hrs by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539083	Cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 14 uM after 12 hrs using propidium iodide staining by flow cytometry relative to control	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539067	Growth inhibition in human HT-29 cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539101	Induction of apoptosis in human HeLa cells assessed as cell death in presence of 25 uM of caspase-3 inhibitor z-VAD-fmk	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539115	Induction of p38 expression in human HeLa cells at 21 uM after 8 hrs by Western blotting	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539112	Induction of apoptosis in human HeLa cells assessed as reduction in expression of chk1 at 14 to 21 uM by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539092	Induction of apoptosis in human HeLa cells assessed as increase in production of p21 at 14 to 21 uM after 12 hrs by immunoblot assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539073	Growth inhibition in human HeLa cells after 72 hrs by MTT assay	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
AID539106	Cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 14 uM after 36 hrs using propidium iodide staining by flow cytometry relative to control	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (20.00)	29.6817
2010's	16 (80.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	20 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	2.11	1	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
maleic anhydride Maleic Anhydrides: Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.. maleic anhydride : A cyclic dicarboxylic anhydride that is the cyclic anhydride of maleic acid.	2.01	1	cyclic dicarboxylic anhydride; furans	allergen
furan furan : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.	2.01	1	furans; mancude organic heteromonocyclic parent; monocyclic heteroarene	carcinogenic agent; hepatotoxic agent; Maillard reaction product
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.1	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	2.11	1	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.02	1
sesquiterpenes [no description available]	2.11	1
geldanamycin [no description available]	2.07	1
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.11	1
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	2.06	1	glycoside
chitosan [no description available]	2.13	1

Condition	Relationship Strength	Studies
Anaphylactic Reaction [description not available]	2.08	1
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	7.08	1
Cholangiocellular Carcinoma [description not available]	2.1	1
Bile Duct Cancer [description not available]	2.1	1
Invasiveness, Neoplasm [description not available]	2.1	1
Bile Duct Neoplasms Tumors or cancer of the BILE DUCTS.	2.1	1
Cholangiocarcinoma A malignant tumor arising from the epithelium of the BILE DUCTS.	7.1	1
Cancer of Cervix [description not available]	2.11	1
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	2.11	1
Bone Loss, Osteoclastic [description not available]	2.08	1
Innate Inflammatory Response [description not available]	2.07	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.07	1

mycoepoxydiene

Description

Cross-References

Synonyms (4)

Research Excerpts

Overview

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Bioassays (52)

Research

Studies (20)

Study Types

mycoepoxydiene

Description

Cross-References

Synonyms (4)

Research Excerpts

Overview

Actions

Bioassays (52)

Research

Studies (20)

Study Types

Related Drugs (11)

Related Conditions (12)